Il4 - interleukin 4 Gene

中文名称：白细胞介素 4

种属: Rattus norvegicus

同用名: Il4e12

基因 ID: 287287 | 基因类型: protein coding

关于 Il4

Primary_assembly 10: 37,771,203-37,776,750 reverse strand.mRatBN7.2:CM026983.1

This gene has 1 transcript (splice variant), 92 orthologues and is associated with 113 phenotypes. Low expression observed in reference dataset.

功能概要

预测该基因编码的蛋白可启动细胞因子活性。参与多个过程，包括生物合成过程的正向调节；白细胞迁移的正向调节；和防御反应的调节。位于细胞外空间。用于研究抗基底膜肾小球肾炎；自身免疫性甲状腺炎;和盆腔炎。多种疾病的生物标志物，包括脑血管疾病（多种）；间质性肺病（多发性）；刺激性皮炎;原发性胆汁性胆管炎;和鼻炎（多种）。该基因的人类直系同源物与多种疾病有关，包括哮喘（多种）；自身免疫性疾病（多种）；乙型肝炎；丙型肝炎;和胰腺癌（多发）。与人 IL4（白细胞介素 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable cytokine activity. Involved in several processes, including positive regulation of biosynthetic process; positive regulation of leukocyte migration; and regulation of defense response. Located in extracellular space. Used to study anti-basement membrane glomerulonephritis; autoimmune thyroiditis; and pelvic inflammatory disease. Biomarker of several diseases, including cerebrovascular disease (multiple); interstitial lung disease (multiple); irritant dermatitis; primary biliary cholangitis; and rhinitis (multiple). Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic Cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Apr 2022]

Il4 基因产物(1)

mRNA	Protein	Name
NM_201270.1	NP_958427.1	interleukin-4 precursor

基因本体论

生物过程
细胞组分

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to mercury ion	IEP IEP: 通过表达模式推断	7657819	RGD
involved in female pregnancy	IEP IEP: 通过表达模式推断	19617880	RGD
involved in microglial cell activation	IDA IDA: 通过直接分析推断	23786632	RGD
involved in negative regulation of acute inflammatory response	IDA IDA: 通过直接分析推断	17250684	RGD
involved in negative regulation of chronic inflammatory response	IDA IDA: 通过直接分析推断	16869003	RGD
involved in negative regulation of macrophage activation	IMP IMP: 通过突变表型推断	20623539	RGD
involved in negative regulation of nitric oxide biosynthetic process	IDA IDA: 通过直接分析推断	18182309	RGD
involved in neuroinflammatory response	IDA IDA: 通过直接分析推断	27235345	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: 通过直接分析推断	11572871	RGD
involved in positive regulation of amyloid-beta clearance	IDA IDA: 通过直接分析推断	18941241	RGD
involved in positive regulation of cell population proliferation	IDA IDA: 通过直接分析推断	17125592	RGD
involved in positive regulation of defense response to virus by host	IDA IDA: 通过直接分析推断	9721086	RGD
involved in positive regulation of eosinophil chemotaxis	IDA IDA: 通过直接分析推断	11071660	RGD
involved in positive regulation of gene expression	IDA IDA: 通过直接分析推断	18941241	RGD
involved in positive regulation of interleukin-10 production	IDA IDA: 通过直接分析推断	17125592	RGD
involved in positive regulation of mononuclear cell migration	IDA IDA: 通过直接分析推断	11071660	RGD
involved in positive regulation of reactive oxygen species biosynthetic process	IDA IDA: 通过直接分析推断	24073824	RGD
involved in positive regulation of receptor-mediated endocytosis	IDA IDA: 通过直接分析推断	18941241	RGD
involved in regulation of proton transport	IDA IDA: 通过直接分析推断	11739109	RGD
involved in response to cytokine	IEP IEP: 通过表达模式推断	18231731	RGD
involved in response to ethanol	IEP IEP: 通过表达模式推断	20116195	RGD
involved in response to nutrient	IEP IEP: 通过表达模式推断	19608731	RGD
involved in response to organic cyclic compound	IEP IEP: 通过表达模式推断	18499367	RGD
involved in response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	18953683	RGD
involved in retina development in camera-type eye	IEP IEP: 通过表达模式推断	23070471	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	18557728	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Il4 蛋白结构

IL4_13

0
100
147 a.a.

蛋白主名

其他名称

interleukin-4

B-cell IGG differentiation factor	B-cell growth factor 1
B-cell stimulatory factor 1	BSF-1
IL-4	lymphocyte stimulatory factor 1

相关产品

Approval

生物活性分子 (7)

目录号	产品名	作用方式	纯度	是否罕见病
HY-B0539	Desloratadine		99.83%	是
HY-108013	Armillarisin A		99.80%	否
HY-B0446	Naphazoline hydrochloride		98.12%	否
HY-17002	Suplatast (Tosilate)	Inhibitor	98.33%	否
HY-111326A	Naphazoline nitrate		≥98.0%	否
HY-B0010C	(S,S)-Formoterol	Activator	/	否
HY-111326	Naphazoline		/	否

抗体抑制剂 (2)

目录号	产品名	作用方式	纯度	是否罕见病
HY-P9926	Dupilumab	Inhibitor	≥99.2%	否
HY-P99025	Lebrikizumab	Inhibitor	99.90%	否

Clinical Phase

生物活性分子 (1)

目录号	产品名	作用方式	纯度	Phase
HY-144683	PF-07038124	Inhibitor	/	Phase 2

抗体抑制剂 (4)

目录号	产品名	作用方式	纯度	Phase
HY-P990093	Stapokibart	Inhibitor	96.34%	Phase 3
HY-P990090	Rademikibart	Inhibitor	98.69%	Phase 3
HY-P99724	Manfidokimab		95.00%	Phase 2
HY-P99883	Romilkimab		/	Phase 2

Pre-clinical Phase

生物活性分子 (27)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-126360	Oxazolone		≥98.0%	否
HY-134771	YM-341619	Inhibitor	99.06%	否
HY-139092	IL-4-inhibitor-1	Inhibitor	98.14%	否
HY-N0600	Ginsenoside F3	Modulator	99.84%	否
HY-N3312	Matairesinol		98.33%	否
HY-N2426	Clerodendrin	Inhibitor	99.66%	否
HY-141582	Ceramide 3		≥98.0%	否
HY-N7652	Terminolic acid	Inhibitor	99.63%	否
HY-125019	iJak-381	Inhibitor	99.86%	否
HY-15131	PNRI-299	Inhibitor	/	否
HY-116609	C6 L-threo Ceramide	Inhibitor	/	否
HY-144683A	PF-07038124 hydrochloride	Inhibitor	/	否
HY-144684	PDE4-IN-8	Inhibitor	/	否
HY-155951	JAK3-IN-14	Inhibitor	99.32%	否
HY-162248	JAK1/2-IN-1	Inhibitor	/	否
HY-162404	Smad2/3-IN-2	Inhibitor	/	否
HY-162405	Smad2/3-IN-1	Inhibitor	/	否
HY-162726	GCS-11	Activator	/	否
HY-162727	GCS-12		/	否
HY-163670	TLR7 agonist 21	Inhibitor	/	否
HY-163704	KRN7000 analog 1		/	否
HY-165484	AVP-13358	Inhibitor	/	否
HY-RS06765	IL4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06766	Il4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06767	Il4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06768	IL4I1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS06769	IL4R Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

抗体抑制剂 (1)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990708	Bizaxofusp		/	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Il4	NCBI	NCBI:3565
Macaca fascicularis	Il4	NCBI	NCBI:107130068
Mus musculus	Il4	NCBI	NCBI:16189
Susscrofa domestica	Il4	NCBI
Macaca mulatta	Il4	NCBI	NCBI:574281

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