Snca - synuclein alpha Gene

中文名称：突触核蛋白 α

种属: Rattus norvegicus

关于 Snca

功能概要

该基因编码的蛋白可启动多种功能，包括磷脂酶结合活性；蛋白质 N-末端结合活性；和微管蛋白结合活性。涉及多个过程，包括对可卡因的行为反应；氮化合物代谢过程的负调控；和对地昔帕明的反应。位于几种细胞成分中，包括细胞质囊泡；远端轴突；和线粒体。用于研究帕金森病和苯丙胺滥用。精神抑郁症和神经鞘瘤的生物标志物。该基因的人类直系同源物与阿尔茨海默病有关；路易体痴呆；帕金森病；帕金森病 1；和帕金森病 4. 与人类 SNCA（突触核蛋白 alpha）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including Phospholipase binding activity; protein N-terminus binding activity; and tubulin binding activity. Involved in several processes, including behavioral response to cocaine; negative regulation of nitrogen compound metabolic process; and response to desipramine. Located in several cellular components, including cytoplasmic vesicle; distal axon; and mitochondrion. Used to study Parkinson's disease and amphetamine abuse. Biomarker of mental depression and neurilemmoma. Human ortholog(s) of this gene implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Orthologous to human SNCA (synuclein alpha). [provided by Alliance of Genome Resources, Apr 2022]