2. Gene
  3. Rnf4 - ring finger protein 4 Gene

Rnf4 - ring finger protein 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 29274 | 基因类型: protein coding

关于 Rnf4

功能概要

Enables several functions, including SUMO polymer binding activity; TBP-class protein binding activity; and nuclear receptor binding activity. Involved in several processes, including cellular response to gamma radiation; cellular response to hydroxyurea; and protein ubiquitination. Located in cytosol and nucleoplasm. Colocalizes with PML body. Orthologous to human RNF4 (ring finger protein 4). [provided by Alliance of Genome Resources, Apr 2022]

Rnf4 基因产物(1)

mRNA Protein Name
NM_019182.2 NP_062055.1 E3 ubiquitin-protein ligase RNF4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
11319220 RGD
enables SUMO polymer binding IDA
IDA: 通过直接分析推断
18408734 RGD
enables SUMO polymer binding IPI
IPI: 通过物理相互作用推断
18408734 RGD
enables TBP-class protein binding IDA
IDA: 通过直接分析推断
9710597 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21857666 RGD
enables nuclear androgen receptor binding IPI
IPI: 通过物理相互作用推断
9710597 RGD
enables nuclear estrogen receptor binding IPI
IPI: 通过物理相互作用推断
9710597 RGD
enables nucleosome binding IDA
IDA: 通过直接分析推断
11319220 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
20696907 RGD
enables ubiquitin conjugating enzyme binding IPI
IPI: 通过物理相互作用推断
21857666 RGD
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
21857666 RGD
enables ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
18408734 RGD
enables ubiquitin-protein transferase activity IMP
IMP: 通过突变表型推断
14987998 RGD
enables zinc ion binding IDA
IDA: 通过直接分析推断
21857666 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to arsenic-containing substance IEP
IEP: 通过表达模式推断
20943951 RGD
involved in cellular response to cytokine stimulus IEP
IEP: 通过表达模式推断
11292317 RGD
involved in cellular response to gamma radiation IMP
IMP: 通过突变表型推断
22661230 RGD
involved in cellular response to hydroxyurea IMP
IMP: 通过突变表型推断
22661230 RGD
involved in cellular response to testosterone stimulus IDA
IDA: 通过直接分析推断
9710597 RGD
involved in male gonad development IEP
IEP: 通过表达模式推断
12351196 RGD
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
11319220 RGD
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
9710597 RGD
involved in protein K11-linked ubiquitination IDA
IDA: 通过直接分析推断
18408734 RGD
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
18408734 RGD
involved in protein K6-linked ubiquitination IDA
IDA: 通过直接分析推断
18408734 RGD
involved in protein K63-linked ubiquitination IDA
IDA: 通过直接分析推断
18408734 RGD
involved in protein autoubiquitination IDA
IDA: 通过直接分析推断
21857666 RGD
involved in protein autoubiquitination IMP
IMP: 通过突变表型推断
14987998 RGD
involved in protein ubiquitination IMP
IMP: 通过突变表型推断
14987998 RGD
involved in response to arsenic-containing substance IDA
IDA: 通过直接分析推断
20943951 RGD
involved in response to estradiol IEP
IEP: 通过表达模式推断
14749358 RGD
involved in response to human chorionic gonadotropin IEP
IEP: 通过表达模式推断
14749358 RGD
involved in spermatogenesis IEP
IEP: 通过表达模式推断
12351196 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in PML body IDA
IDA: 通过直接分析推断
20943951 RGD
located in nucleoplasm IDA
IDA: 通过直接分析推断
20943951 RGD
located in nucleus IDA
IDA: 通过直接分析推断
11319220 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

E3 ubiquitin-protein ligase RNF4

E3 ubiquitin ligase RNF4

RING-type E3 ubiquitin transferase RNF4

SNURF

small nuclear ring finger protein

Rnf4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Rnf4 O88846 APEX1 Homo sapiens P27695
Anti Tag CoIP
20696907
种属内
Rnf4 O88846 TDG Homo sapiens Q13569
Anti Tag CoIP
20696907
种属内
Rnf4 O88846 SUMO2 Homo sapiens P61956
Pull Down
21252943
种属内
Rnf4 O88846 PARP1 Homo sapiens P09874
Anti Bait CoIP
19779455
种属内
Rnf4 O88846 TRIM28 Homo sapiens Q13263
Pull Down
21252943
种属内
Rnf4 O88846 Rnf4 Rattus norvegicus O88846
FRET
21857666
种属内
Rnf4 O88846 Rnf4 Rattus norvegicus O88846
Solution Sedimentation
21857666
种属内
Rnf4 O88846 SUMO3 Homo sapiens P55854
Pull Down
21857666
种属内
Rnf4 O88846 Rnf4 Rattus norvegicus O88846
X-Ray Diffraction
21857666
种属内
Rnf4 O88846 Rnf4 Rattus norvegicus O88846
GMS
21857666
种属内
Rnf4 O88846 ubiq_human Homo sapiens DIP-24261N
Pull Down
21857666
种属间
Rnf4 O88846 UBE2D1 Homo sapiens P51668
Pull Down
21857666
种属内
Rnf4 O88846 UHRF1 Homo sapiens Q96T88
Pull Down
21252943
种属内
Rnf4 O88846 RPS27A Bos taurus P62990
Pull Down
21857666
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-143346 CCW16 98.63% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rnf4 NCBI NCBI:6047
Canis familiaris Rnf4 NCBI NCBI:100855762
Mus musculus Rnf4 NCBI NCBI:19822
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