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  2. Pak4 - p21 (RAC1) activated kinase 4 Gene

Pak4 - p21 (RAC1) activated kinase 4 Gene

中文名称:p21 (RAC1) 激活激酶 4

种属: Rattus norvegicus

基因 ID: 292756 | 基因类型: protein coding

关于 Pak4

Primary_assembly 1: 83,849,904-83,859,413 reverse strand.mRatBN7.2:CM026974.1

This gene has 1 transcript (splice variant), 162 orthologues, 36 paralogues and is associated with 6 phenotypes. Biased expression in Lung (RPKM 45.3), Adrenal (RPKM 43.4) and 9 other tissues.

功能概要

预测该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。预计参与多个过程,包括内皮细胞凋亡过程的负调控;血管生成的正向调节;和 MAPK 级联的调节。预计在有机环状化合物和树突棘发育的细胞反应的上游或内部起作用。预计在细胞质中有活性。与人 PAK4(p21 (RAC1) 激活激酶 4)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable protein serine/threonine kinase activity. Predicted to be involved in several processes, including negative regulation of endothelial cell apoptotic process; positive regulation of angiogenesis; and regulation of MAPK cascade. Predicted to act upstream of or within cellular response to organic cyclic compound and dendritic spine development. Predicted to be active in cytoplasm. Orthologous to human PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Apr 2022]

Pak4 基因产物(1)

mRNA Protein Name
NM_001106238.1 NP_001099708.1 serine/threonine-protein kinase PAK 4

Pak4 蛋白结构

CRIB_PAK_like

CRIB_PAK_like: cd01093 (9 - 47)

PKc_like

PKc_like: cl21453 (301 - 592)

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  • 593 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase PAK 4

p21 (CDKN1A)-activated kinase 4

p21 protein (Cdc42/Rac)-activated kinase 4

p21-activated kinase 4

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pak4 NCBI NCBI:10298