Hras - HRas proto-oncogene, GTPase Gene

中文名称：HRas 原癌基因，GTP 酶

种属: Rattus norvegicus

同用名: HRAS1; c-H-ras

关于 Hras

功能概要

预测该基因编码的蛋白可启动 GTPase 活动；胍基核糖核苷酸结合活性；和蛋白质 C 末端结合活性。参与多个过程，包括细胞衰老； DNA 复制的正调控； ERK1 和 ERK2 级联的正调控。在 Ras 蛋白信号转导的正调节上游或正调节内起作用。位于细胞内膜结合的细胞器和质膜中。用于研究糖尿病视网膜病变和肝癌。该基因的人类直系同源物与多种疾病有关，包括 Costello 综合征；自闭症；癌（多发性）；表皮痣;和巨大的先天性黑色素细胞痣。与人类 HRAS（HRas 原癌基因，GTPase）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable GTPase activity; guanyl ribonucleotide binding activity; and protein C-terminus binding activity. Involved in several processes, including cellular senescence; positive regulation of DNA replication; and positive regulation of ERK1 and ERK2 cascade. Acts upstream of or within positive regulation of Ras protein signal transduction. Located in intracellular membrane-bounded organelle and plasma membrane. Used to study diabetic retinopathy and liver carcinoma. Human ortholog(s) of this gene implicated in several diseases, including Costello syndrome; autistic disorder; carcinoma (multiple); epidermal nevus; and large congenital melanocytic nevus. Orthologous to human HRAS (HRas proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2022]