Pdia3 - protein disulfide isomerase family A, member 3 Gene

中文名称：蛋白质二硫键异构酶家族 A，成员 3

种属: Rattus norvegicus

同用名: ER60; ERp57; Grp58

关于 Pdia3

功能概要

该基因编码的蛋白可启动 MHC I 类蛋白结合活性；肽酶活性；和蛋白质二硫化物还原酶（谷胱甘肽）活性。参与多个过程，包括细胞对壬基酚的反应；对苯的反应；和对缺血的反应。位于多个细胞成分中，包括顶体囊泡；线粒体膜间隙；和光滑的内质网。 TAP 复合体的一部分。用于研究自身免疫性肝炎和肠易激综合征。新生儿窒息生物标志物；肠易激综合症;肝硬化;创伤后应激障碍；和肺动脉高压。该基因的人类直系同源物与自身免疫性肝炎有关。与人类 PDIA3（蛋白质二硫键异构酶家族 A 成员 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables MHC class I protein binding activity; peptidase activity; and protein-disulfide reductase (glutathione) activity. Involved in several processes, including cellular response to nonylphenol; response to benzene; and response to ischemia. Located in several cellular components, including acrosomal vesicle; mitochondrial intermembrane space; and smooth endoplasmic reticulum. Part of TAP complex. Used to study autoimmune hepatitis and irritable bowel syndrome. Biomarker of asphyxia neonatorum; irritable bowel syndrome; liver cirrhosis; post-traumatic stress disorder; and pulmonary hypertension. Human ortholog(s) of this gene implicated in autoimmune hepatitis. Orthologous to human PDIA3 (protein disulfide isomerase family A member 3). [provided by Alliance of Genome Resources, Apr 2022]