Sgk1 - serum/glucocorticoid regulated kinase 1 Gene

中文名称：血清/糖皮质激素调节激酶 1

种属: Rattus norvegicus

同用名: Sgk

关于 Sgk1

功能概要

该基因编码的蛋白可启动 3-磷酸肌醇依赖性蛋白激酶结合活性；蛋白丝氨酸/苏氨酸激酶活性；和 tau 蛋白结合活性。涉及多个过程，包括神经元的生成；糖皮质激素介导的信号通路；和学习或记忆。在胰岛素刺激的细胞反应上游或细胞反应内起作用；钠离子转运的正向调节；和蛋白质定位的调节。位于神经元投射；核;和细胞质的核周区。短暂性脑缺血的生物标志物。该基因的人类直系同源物与高血压有关。与人 SGK1（血清/糖皮质激素调节激酶 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3-phosphoinositide-dependent protein kinase binding activity; protein serine/threonine kinase activity; and Tau Protein binding activity. Involved in several processes, including generation of neurons; glucocorticoid mediated signaling pathway; and learning or memory. Acts upstream of or within cellular response to Insulin stimulus; positive regulation of sodium ion transport; and regulation of protein localization. Located in neuron projection; nucleus; and perinuclear region of cytoplasm. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human SGK1 (serum/glucocorticoid regulated kinase 1). [provided by Alliance of Genome Resources, Apr 2022]