Htr2a - 5-hydroxytryptamine receptor 2A Gene

中文名称：5-羟色胺受体 2A

种属: Rattus norvegicus

同用名: 5Ht-2; 5-HT2A

关于 Htr2a

功能概要

预计该基因编码的蛋白具有多种功能，包括 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine 结合活性； Gq/11-偶联血清素受体活性；和血清素结合活性。参与多个过程，包括维持血管直径；检测与疼痛感觉相关的刺激；和化学突触传递的调节。位于多种细胞成分中，包括细胞体纤维；树突轴；和神经细胞体。在谷氨酸能突触中活跃。是突触后膜的组成部分和突触前膜的组成部分。用于研究充血性心力衰竭；高血糖;和胰腺炎。膀胱颈梗阻和精神分裂症的生物标志物。该基因的人类直系同源基因与多种疾病有关，包括酒精使用障碍；神经性厌食症;严重抑郁症;肥胖;和强迫症。与人 HTR2A（5-羟色胺受体 2A）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding activity; Gq/11-coupled serotonin receptor activity; and serotonin binding activity. Involved in several processes, including blood vessel diameter maintenance; detection of stimulus involved in sensory perception of pain; and modulation of chemical synaptic transmission. Located in several cellular components, including cell body fiber; dendritic shaft; and neuronal cell body. Is active in glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study congestive heart failure; hyperglycemia; and pancreatitis. Biomarker of bladder neck obstruction and schizophrenia. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; anorexia nervosa; major depressive disorder; obesity; and obsessive-compulsive disorder. Orthologous to human HTR2A (5-hydroxytryptamine receptor 2A). [provided by Alliance of Genome Resources, Apr 2022]