2. Gene
  3. S1pr1 - sphingosine-1-phosphate receptor 1 Gene

S1pr1 - sphingosine-1-phosphate receptor 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：1-磷酸鞘氨醇受体 1

种属: Rattus norvegicus

同用名: Edg1

基因 ID: 29733 | 基因类型: protein coding

关于 S1pr1

Primary_assembly 2: 203,621,587-203,629,681 reverse strand.mRatBN7.2:CM026975.1

This gene has 1 transcript (splice variant), 199 orthologues, 18 paralogues and is associated with 11 phenotypes. Biased expression in Lung (RPKM 299.1), Spleen (RPKM 279.3) and 8 other tissues.

功能概要

该基因编码的蛋白可启动 G 蛋白偶联受体活性和鞘脂结合活性。参与多个过程，包括G蛋白偶联受体信号通路；应力纤维组装的负调节；和 GTPase 活性的正调节。预计位于质膜和核质的外侧。预测为质膜的固有成分。预计在细胞质和质膜中有活性。用于研究高血压。与人 S1PR1（1-磷酸鞘氨醇受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled receptor activity and sphingolipid binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of stress fiber assembly; and positive regulation of GTPase activity. Predicted to be located in external side of plasma membrane and nucleoplasm. Predicted to be intrinsic component of plasma membrane. Predicted to be active in cytoplasm and plasma membrane. Used to study hypertension. Orthologous to human S1PR1 (sphingosine-1-phosphate receptor 1). [provided by Alliance of Genome Resources, Apr 2022]

S1pr1 基因产物(1)

mRNA Protein Name
NM_017301.2 NP_058997.1 sphingosine 1-phosphate receptor 1
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled receptor activity IMP
IMP: 通过突变表型推断
11557736 RGD
enables sphingolipid binding IDA
IDA: 通过直接分析推断
9765227 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
11557736 RGD
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
9765227 RGD
involved in endothelial cell differentiation IEP
IEP: 通过表达模式推断
7959012 RGD
involved in negative regulation of stress fiber assembly IDA
IDA: 通过直接分析推断
11094076 RGD
involved in neuron differentiation IEP
IEP: 通过表达模式推断
7959012 RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
9765227 RGD
involved in positive regulation of GTPase activity IDA
IDA: 通过直接分析推断
14711826 RGD
involved in positive regulation of cell migration IDA
IDA: 通过直接分析推断
11557736 RGD
involved in positive regulation of positive chemotaxis IDA
IDA: 通过直接分析推断
11094076 RGD
involved in positive regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
11557736 RGD
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
14711826 RGD
involved in transmission of nerve impulse IEP
IEP: 通过表达模式推断
7959012 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

S1pr1 蛋白结构

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (46 - 322)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (47 - 73)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (80 - 105)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (117 - 147)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (158 - 178)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (198 - 227)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (249 - 279)

7tmA_S1PR1_Edg1

7tmA_S1PR1_Edg1: cd15346 (290 - 315)

  • 0
  • 100
  • 200
  • 300
  • 383 a.a.
蛋白主名 其他名称

sphingosine 1-phosphate receptor 1

EDG1 (Edg1)

S1P receptor 1

S1P receptor Edg-1

S1P1

endothelial differentiation G-protein coupled receptor 1

endothelial differentiation sphingolipid G-protein-coupled receptor 1

sphingosine 1-phosphate receptor Edg-1

相关产品

Approval
生物活性分子 (5)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12355 Siponimod Agonist 99.95% 否
HY-12288 Ozanimod Agonist 99.88% 是
HY-10569 Ponesimod Agonist 99.81% 是
HY-12288A Ozanimod hydrochloride Modulator 99.19% 是
HY-12355A Siponimod hemifumarate Agonist / 否
Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-17606 Cenerimod Agonist 99.43% Phase 3
HY-115831 SAR247799 Agonist 97.21% Phase 1
Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W008947 SEW​2871 Agonist 99.77% 否
HY-136578 RP101988 Agonist 98.92% 否
HY-111253 CYM-5478 Agonist 99.90% 否
HY-147660 IMMH001 Agonist 98.10% 否
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist ≥98.0% 否
HY-136576 RP101075 Agonist / 否
HY-108492 TC-SP 14 Agonist / 否
HY-158417 KSI-6666 Antagonist / 否
HY-119245 Udifitimod Modulator / 否
HY-136577 RP101442 Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens S1pr1 NCBI NCBI:1901
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