2. Gene
  3. Myd88 - MYD88, innate immune signal transduction adaptor Gene

Myd88 - MYD88, innate immune signal transduction adaptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：MYD88 ，先天免疫信号转导适配器

种属: Rattus norvegicus

基因 ID: 301059 | 基因类型: protein coding

关于 Myd88

Primary_assembly 8: 119,074,437-119,079,415 reverse strand.mRatBN7.2:CM026981.1

This gene has 4 transcripts (splice variants), 200 orthologues and is associated with 61 phenotypes. Biased expression in Spleen (RPKM 125.3), Thymus (RPKM 16.6) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 Toll 结合活性和白细胞介素 1 受体结合活性。参与JNK级联；细胞表面受体信号通路；和平滑肌细胞增殖的正调节。位于突触后密度。部分含蛋白质复合物。该基因的人类直系同源物与华氏巨球蛋白血症有关；结直肠癌；和原发性免疫缺陷病。与人 MyD88 同源（MYD88 先天免疫信号转导接头）。 [由基因组资源联盟提供，2022 年 4 月]

Enables Toll binding activity and interleukin-1 receptor binding activity. Involved in JNK cascade; cell surface receptor signaling pathway; and positive regulation of smooth muscle cell proliferation. Located in postsynaptic density. Part of protein-containing complex. Human ortholog(s) of this gene implicated in Waldenstroem's macroglobulinemia; colorectal carcinoma; and primary immunodeficiency disease. Orthologous to human MyD88 (MyD88 innate immune signal transduction adaptor). [provided by Alliance of Genome Resources, Apr 2022]

Myd88 基因产物(1)

mRNA Protein Name
NM_198130.2 NP_937763.2 myeloid differentiation primary response protein MyD88
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Toll binding IDA
IDA: 通过直接分析推断
14962484 RGD
enables interleukin-1 receptor binding IPI
IPI: 通过物理相互作用推断
21314939 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
19144836 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
14962484 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in JNK cascade IMP
IMP: 通过突变表型推断
15890643 RGD
involved in Toll signaling pathway IDA
IDA: 通过直接分析推断
14962484 RGD
involved in cytokine-mediated signaling pathway IMP
IMP: 通过突变表型推断
15890643 RGD
involved in positive regulation of smooth muscle cell proliferation IMP
IMP: 通过突变表型推断
15890643 RGD
involved in response to amine IEP
IEP: 通过表达模式推断
31068809 RGD
involved in response to amino acid IEP
IEP: 通过表达模式推断
21276439 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
21276439 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
33575076 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of protein-containing complex IDA
IDA: 通过直接分析推断
21314939 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Myd88 蛋白结构

Death_MyD88

Death_MyD88: cd08312 (28 - 105)

TIR

TIR: smart00255 (160 - 295)

  • 0
  • 100
  • 200
  • 296 a.a.
蛋白主名 其他名称

myeloid differentiation primary response protein MyD88

myeloid differentiation primary response 88

myeloid differentiation primary response gene 88

相关产品

Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139397 TJ-M2010-5 Inhibitor 99.85% 否
HY-50937 ST 2825 Inhibitor 99.92% 否
HY-110204 Heclin 98.21% 否
HY-N0703 Schaftoside Inhibitor 99.67% 否
HY-19744 T6167923 Inhibitor 99.08% 否
HY-149992 MyD88-IN-1 Inhibitor 99.95% 否
HY-110195 Smurf1-IN-A01 99.81% 否
HY-18976 UF010 99.84% 否
HY-Y0278 Chloranil Inducer 98% 否
HY-W011400 TLR1 ≥99.0% 否
HY-W014223 2,4′-Dihydroxybenzophenone Inhibitor 95.53% 否
HY-163775 Anti-inflammatory agent 88 Agonist / 否
HY-P10719 Pepinh-MYD Inhibitor / 否
HY-164173 LPS-PG / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Myd88 NCBI NCBI:4615
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