2. Gene
  3. Rel - REL proto-oncogene, NF-kB subunit Gene

Rel - REL proto-oncogene, NF-kB subunit Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：REL 原癌基因，NF-kB 亚单位

种属: Rattus norvegicus

基因 ID: 305584 | 基因类型: protein coding

关于 Rel

Primary_assembly 14: 97,695,161-97,720,892 reverse strand.mRatBN7.2:CM026987.1

This gene has 3 transcripts (splice variants), 208 orthologues, 4 paralogues and is associated with 14 phenotypes. Biased expression in Spleen (RPKM 85.), Thymus (RPKM 42.3) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 DNA 结合转录因子活性和序列特异性 DNA 结合活性。参与 I-kappaB 激酶/NF-kappaB 信号传导和神经元死亡的负调节。位于细胞质和细胞核中。转录调节复合物的一部分。与人类 REL（REL 原癌基因，NF-kB 亚基）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables DNA-binding transcription factor activity and sequence-specific DNA binding activity. Involved in I-kappaB kinase/NF-kappaB signaling and negative regulation of neuron death. Located in cytoplasm and nucleus. Part of transcription regulator complex. Orthologous to human REL (REL proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Rel 基因产物(3)

mRNA Protein Name
XM_039092883.1 XP_038948811.1 proto-oncogene c-Rel isoform X3
XM_039092882.1 XP_038948810.1 proto-oncogene c-Rel isoform X2
XM_008770448.3 XP_008768670.2 proto-oncogene c-Rel isoform X1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
15312903 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
11912207 RGD
located in nucleus IDA
IDA: 通过直接分析推断
11912207 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Rel 蛋白结构

RHD-n_c-Rel

RHD-n_c-Rel: cd07933 (7 - 178)

IPT_NFkappaB

IPT_NFkappaB: cd01177 (185 - 280)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 595 a.a.
蛋白主名 其他名称

proto-oncogene c-Rel

reticuloendotheliosis oncogene

v-rel avian reticuloendotheliosis viral oncogene homolog

v-rel reticuloendotheliosis viral oncogene homolog

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-17371A (rel)-Oxaliplatin / 否
Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-122359A rel-Levormeloxifene / Phase 3
HY-117283 rel-Aprikalim / Phase 2
HY-135238 (rel)-RSD 921 / Phase 2
Pre-clinical Phase
生物活性分子 (82)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15917 DL-dithiothreitol Inhibitor 99.43% 否
HY-12276 MALT1 inhibitor MI-2 Inhibitor 99.95% 否
HY-139426A (rel)-ML-SI3 99.81% 否
HY-119940 MC180295 Inhibitor 98.89% 否
HY-124179 IT-901 Inhibitor ≥99.0% 否
HY-120006A (rel)-AR234960 Agonist 99.42% 否
HY-121508 (E/Z)-IT-603 Inhibitor 99.91% 否
HY-B0757A (±)-α-Tocopherol nicotinate 99.80% 否
HY-B1890 (±)-Catechin Inhibitor 98.38% 否
HY-160440 rel-VU6021625 99.67% 否
HY-160477 DC-SX029 Inhibitor 98.07% 否
HY-N0683A rel-α-Vitamin E ≥70.0% 否
HY-112163A rel-Zotatifin 97.32% 否
HY-113068 (rel)-β-Tocopherol Inhibitor ≥99.0% 否
HY-114324A rel-PROTAC PARP1 degrader Degrader 98.99% 否
HY-121964 cis-Piperidine-2,3-dicarboxylic acid Agonist ≥98.0% 否
HY-128838A (rel)-PROTAC ERRα Degrader-1 95.89% 否
HY-18941B (rel)-Eglumegad Agonist ≥97.0% 否
HY-77493 (rel)-Tivantinib 96.45% 否
HY-N2207 rel-(8R,8'R)-Dimethyl-(7S,7'R)-bis(3,4-methylenedioxyphenyl)tetrahydro-furan 99.95% 否
HY-101387 rel-ACPT-I Agonist ≥99.0% 否
HY-111537 rel-AZ5576 / 否
HY-106874B rel-Delequamine / 否
HY-110020 rel-O-2050 Antagonist / 否
HY-113239S1 rel-Hydroxycotinine-d3 / 否
HY-122495 rel-Quinpirole dihydrochloride Agonist / 否
HY-12422C rel-(2S,3R)-Voruciclib Inhibitor / 否
HY-12422E rel-(2S,3R)-Voruciclib hydrochloride / 否
HY-124874 (rel)-Asperparaline A Antagonist / 否
HY-12650A (rel)-Mirogabalin Inhibitor / 否
HY-13204S1 rel-Biperiden-d5 Inhibitor / 否
HY-13204S2 rel-Biperiden EP impurity A-d5 Inhibitor / 否
HY-13204S3 rel-Biperiden EP impurity B-d5 Inhibitor / 否
HY-13607A (rel)-BMS-641988 Antagonist / 否
HY-140902 rel-Biotin-PEG3-C3-NH2 / 否
HY-143785S rel-Saxagliptin-15N,d2 hydrochloride / 否
HY-144681A rel-LY3372689 Inhibitor / 否
HY-14588S (rel)-Lopinavir-d8 / 否
HY-14645B DHMEQ racemate Inhibitor / 否
HY-151216S rel-Paroxetine-d4 hydrochloride / 否
HY-15793A Trans (2,3)-Dihydrotetrabenazine Inhibitor / 否
HY-17423S1 rel-Abacavir-d4 / 否
HY-17447SA Tranylcypromine-d5 hydrochloride Inhibitor / 否
HY-18295A rel-Erteberel Agonist / 否
HY-18617 rel-SB-612111 hydrochloride Inhibitor / 否
HY-65039A rel-Boc-Hyp-OMe / 否
HY-78746A (3S,4R,5S)-rel-3-(3-Chloro-2-fluorophenyl)-4-(4-chloro-2-fluorophenyl)-4-cyano-5-neopentylpyrrolidine-2-carboxylic acid 96.90% 否
HY-90001S3 rel-Ritonavir-d6 ≥98.0% 否
HY-B0141S7 rel-Estradiol-13C6 / 否
HY-B0176AS rel-Sertraline-d3 hydrochloride Inhibitor / 否
HY-B0511S1 rel-Biotin-d4 98.04% 否
HY-N10837 rel-3R-Methoxy-4S-furanogermacra-1E,10(15)-dien-6-one / 否
HY-RS06707 IL17REL Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11823 REL Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11824 Rel Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11825 Rel Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-W015597S rel-3a,4,7,7a-Tetrahydro-1H-isoindole-1,3(2H)-dione-d6 / 否
HY-W415923 rel-6-Deoxy-6-fluoroglucopyranose / 否
HY-W588220 rel-cis-Pinic acid / 否
HY-W756041 rel-(1S,2S)-Dihydro bupropion-d9 hydrochloride / 否
HY-Y0997 N,N,N′,N′-Tetramethylethylenediamine, for electrophoresis, 99% / 否
HY-100243A Norcisapride / 否
HY-10285S1 (rel)-Saxagliptin-13C,d2 TFA Inhibitor / 否
HY-106899A (rel)-MK 287 / 否
HY-128732 rel-(2R,3S)-2,3-Dihydroxysuccinic acid hydrate / 否
HY-13047A rel-S-(+)-Mecamylamine hydrochloride / 否
HY-134180 rel-Carbovir monophosphate / 否
HY-138110 Toladryl Antagonist / 否
HY-14690B rel-Ecopipam hydrobromide Antagonist / 否
HY-157571S N-6-[rel-(2R,6S)-2,6-Dimethyl-4-morpholinyl]-3-pyridinamine-Sonidegib-d8 / 否
HY-157856 rel-4(5)-Epdpe methyl ester / 否
HY-165976 rel-(9R,10R)-9,10-Dihydroxyhexadecanoic acid / 否
HY-166057 trans-15,16-Epoxy-octadecanoic acid / 否
HY-166062 trans-5,6-Epoxy-9(Z),12(Z)-octadecadienoic acid / 否
HY-166238 rel-Linoleic acid-biotin / 否
HY-18957A rel-Lifirafenib / 否
HY-19153 Nepaprazole Inhibitor / 否
HY-B0492S rel-Paroxetine-d4-1 hydrochloride / 否
HY-N9090 erythro-1-(4-Hydroxy-3-methoxyphenyl)propane-1,2-diol / 否
HY-W710914A rel-HDMP 28 hydrochloride / 否
HY-W745349 rel-(1S,2R)-Dihydro bupropion-d9 hydrochloride / 否
HY-W777138 rel-(1S,2R)-Dihydro bupropion-d9 / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rel NCBI NCBI:5966
Canis familiaris Rel NCBI NCBI:474606
Macaca fascicularis Rel NCBI NCBI:102116653
Canis lupus familiaris Rel NCBI
Mus musculus Rel NCBI NCBI:19696
Macaca mulatta Rel NCBI NCBI:717804
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