2. Gene
  3. Rela - RELA proto-oncogene, NF-kB subunit Gene

Rela - RELA proto-oncogene, NF-kB subunit Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：RELA 原癌基因，NF-kB 亚单位

种属: Rattus norvegicus

同用名: NFkB; nos2

基因 ID: 309165 | 基因类型: protein coding

关于 Rela

Primary_assembly 1: 202,924,945-202,935,484 forward strand.mRatBN7.2:CM026974.1

This gene has 5 transcripts (splice variants), 200 orthologues, 4 paralogues and is associated with 88 phenotypes. Biased expression in Lung (RPKM 143.3), Heart (RPKM 121.9) and 9 other tissues.

功能概要

该基因编码的蛋白可启动 RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性。参与多个过程，包括细胞分化的正调节； RNA 聚合酶 II 对 pri-miRNA 转录的正调控；和对钴胺素的反应。位于染色质；胞质溶胶；和核。部分含蛋白质复合物。在突触中活跃。用于研究帕金森症；脑炎;脂肪肝病；和癫痫持续状态。多种疾病的生物标志物，包括急性坏死性胰腺炎；动脉疾病（多发性）；结肠炎;晚期肾脏疾病;和葡萄膜炎。该基因的人类直系同源物与原位导管癌有关；肺非小细胞癌；淋巴瘤;和肾细胞癌。与人类 RELA 同源（RELA 原癌基因，NF-kB 亚基）。 [由基因组资源联盟提供，2022 年 4 月]

Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including positive regulation of cell differentiation; positive regulation of pri-miRNA transcription by RNA polymerase II; and response to cobalamin. Located in chromatin; cytosol; and nucleus. Part of protein-containing complex. Is active in synapse. Used to study Parkinsonism; encephalitis; fatty liver disease; and status epilepticus. Biomarker of several diseases, including acute necrotizing pancreatitis; artery disease (multiple); colitis; end stage renal disease; and uveitis. Human ortholog(s) of this gene implicated in ductal carcinoma in situ; lung non-small cell carcinoma; lymphoma; and renal cell carcinoma. Orthologous to human RELA (RELA proto-oncogene, NF-kB subunit). [provided by Alliance of Genome Resources, Apr 2022]

Rela 基因产物(1)

mRNA Protein Name
NM_199267.2 NP_954888.1 transcription factor p65
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
26908121 RGD
enables double-stranded DNA binding IDA
IDA: 通过直接分析推断
9585425 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15728586 RGD
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
12672265 RGD
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
9918814 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acetaldehyde metabolic process IEP
IEP: 通过表达模式推断
9918814 RGD
involved in cellular response to lipopolysaccharide IDA
IDA: 通过直接分析推断
15728586 RGD
involved in cellular response to lipopolysaccharide IEP
IEP: 通过表达模式推断
9918814 RGD
involved in cellular response to tumor necrosis factor IDA
IDA: 通过直接分析推断
15980038 RGD
involved in negative regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
18073321 RGD
involved in positive regulation of Schwann cell differentiation IMP
IMP: 通过突变表型推断
18385332 RGD
involved in positive regulation of miRNA transcription IMP
IMP: 通过突变表型推断
20546595 RGD
involved in response to amino acid IEP
IEP: 通过表达模式推断
18288455 RGD
involved in response to cAMP IEP
IEP: 通过表达模式推断
18385332 RGD
involved in response to cobalamin IEP
IEP: 通过表达模式推断
18183619 RGD
involved in response to cytokine IEP
IEP: 通过表达模式推断
10715573 RGD
involved in response to ethanol IEP
IEP: 通过表达模式推断
29399060 RGD
involved in response to hydrogen peroxide IEP
IEP: 通过表达模式推断
17454138 RGD
involved in response to insulin IEP
IEP: 通过表达模式推断
18500427 RGD
involved in response to ischemia IEP
IEP: 通过表达模式推断
31583047 RGD
involved in response to lipopolysaccharide IEP
IEP: 通过表达模式推断
17915214 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
17525357 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
18400403 RGD
involved in response to progesterone IEP
IEP: 通过表达模式推断
18274644 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
18543397 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
26908121 RGD
located in cytoplasm IDA
IDA: 通过直接分析推断
11912207 RGD
located in nucleus IDA
IDA: 通过直接分析推断
11912207 RGD
part of protein-containing complex IDA
IDA: 通过直接分析推断
9343439 RGD
is active in synapse EXP
EXP: 通过实验结果推断
8297787 RGD
is active in synapse IDA
IDA: 通过直接分析推断
8297787 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Rela 蛋白结构

RHD-n_RelA

RHD-n_RelA: cd07885 (18 - 186)

IPT_NFkappaB

IPT_NFkappaB: cd01177 (193 - 289)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 550 a.a.
蛋白主名 其他名称

transcription factor p65

nuclear factor kappa B subunit p65

nuclear factor kappaB subunit p65

v-rel avian reticuloendotheliosis viral oncogene homolog A

v-rel reticuloendotheliosis viral oncogene homolog A

Rela 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Rela Q7TQN4 Nos2 Rattus norvegicus Q06518
Anti Bait CoIP
21464294
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11826 RELA Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11827 Rela Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS11828 Rela Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-138110 Toladryl Antagonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rela NCBI NCBI:5970
Canis familiaris Rela NCBI NCBI:483729
Macaca fascicularis Rela NCBI NCBI:101867324
Canis lupus familiaris Rela NCBI
Mus musculus Rela NCBI NCBI:19697
Macaca mulatta Rela NCBI NCBI:715919
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