2. Gene
  3. HLX - H2.0 like homeobox Gene

HLX - H2.0 like homeobox Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：H2.0 类同源框

种属: Homo sapiens

同用名: HB24; HLX1

基因 ID: 3142 | 基因类型: protein coding

关于 HLX

Cytogenetic location: 1q41 Genomic coordinates (GRCh38): 1:220,879,443-220,885,059 (from NCBI)

This gene has 3 transcripts (splice variants), 195 orthologues, 3 paralogues and is associated with 1 phenotype. Broad expression in bone marrow (RPKM 18.6), fat (RPKM 10.7) and 19 other tissues.

功能概要

启用序列特异性 DNA 结合活性。预测通过 RNA 聚合酶 II 参与细胞分化和转录调控。预计在几个过程的上游或内部起作用，包括动物器官发育；肠神经系统发育；和 T 辅助细胞分化的调节。预测位于核内。预测是染色质的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables sequence-specific DNA binding activity. Predicted to be involved in cell differentiation and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including animal organ development; enteric nervous system development; and regulation of T-helper cell differentiation. Predicted to be located in nucleus. Predicted to be part of chromatin. [provided by Alliance of Genome Resources, Apr 2022]

HLX 基因产物(1)

mRNA Protein Name
NM_021958.4 NP_068777.1 H2.0-like homeobox protein
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
9073066 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HLX 蛋白结构

Homeobox

Homeobox: Homeobox domain (279 - 333)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 488 a.a.
蛋白主名 其他名称

H2.0-like homeobox protein

H2.0-like homeo box-1

HLX 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HLX Q14774 LONRF1 Homo sapiens Q17RB8
Validated Y2H
32296183
种属内
HLX Q14774 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
种属内
HLX Q14774 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
种属内
HLX Q14774 MIEN1 Homo sapiens Q9BRT3
Validated Y2H
32296183
种属内
HLX Q14774 C14orf119 Homo sapiens Q9NWQ9
Validated Y2H
32296183
种属内
HLX Q14774 DTX2 Homo sapiens Q86UW9
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Diaphragmatic Hernia-Short Bowel-Asplenia Syndrome
Diaphragmatic Eventration
Osteogenesis Imperfecta, Type Xi

Osteogenesis Imperfecta Type 11

OI11

Osteogenesis Imperfecta Type Xi

Oi, Type Xi

Osteogenesis Imperfecta 11

Oi Type Xi

Oi-Xi
Diaphragm Disease

Abnormality Of The Diaphragm

Disease Of Diaphragm

Diaphragmatic Disorder

Disorder Of Diaphragm
Diaphragmatic Hernia, Congenital

Congenital Diaphragmatic Hernia

Diaphragmatic Hernia

Cdh

Congenital Diaphragmatic Defect

Hernia, Diaphragmatic

Dih

Hernia, Congenital Diaphragmatic

Hcd

Diaphragmatic Defect, Congenital

Diaphragm, Unilateral Agenesis Of

Hemidiaphragm, Agenesis Of

Diaphragmatic Hernia 1

Agenesis Of Hemidiaphragm

Unilateral Agenesis Of Diaphragm

Hernia Diaphragmatic

Hernia Diaphragmatic Congenital

Hernia, Diaphragmatic, Type 1

Hiatus Hernia

Oesophageal Hiatus Hernia

Paraoesophageal Hernia

Sliding Hiatus Hernia

Congenital Diaphragm Hernia

Congenital Diaphragm Defect With Hernia

Gross Congenital Diaphragm Defect
Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa

Foramen Ovale Patent

Ostium Secundum Atrial Septal Defect

Atrial Septal Defect, Ostium Secundum Type

Foramen Ovale, Patent

Defect, Patent Or Persistent, Ostium Secundum

Ostium Secundum Type Atrial Septal Defect

Persistent Ostium Secundum

Asd Ostium Secundum Type

Ostium Secundum Asd

Osasd

Asd, Ostium Secundum Type

Pfo - [Patent Foramen Ovale]

Open Foramen Ovale

Open Oval Foramen

Persistent Foramen Ovale

Secundum Atrial Septal Defect
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-P99118 Serplulimab Inhibitor 99.30% 否
Clinical Phase
抗体抑制剂 (2)
目录号 产品名 作用方式
纯度 Phase
HY-P99785 Opucolimab Inhibitor / Phase 1
HY-P99516 Vulinacimab Inhibitor / Phase 1
Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06221 HLX Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus HLX MGD MGI:96109
Macaca mulatta HLX VGNC VGNC:106382
Canis familiaris HLX VGNC VGNC:50302
Rattus norvegicus HLX RGD RGD:1311961
Bos taurus HLX VGNC VGNC:50277
Felis catus HLX VGNC VGNC:107879
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