2. Gene
  3. ACACB - acetyl-CoA carboxylase beta Gene

ACACB - acetyl-CoA carboxylase beta Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：乙酰辅酶 A 羧化酶 β

种属: Homo sapiens

同用名: ACC2; ACCB; ACCbeta; HACC275; ACACbeta; ACC-beta

基因 ID: 32 | 基因类型: protein coding

关于 ACACB

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,111,189-109,268,226 (from NCBI)

This gene has 15 transcripts (splice variants), 207 orthologues and 4 paralogues. Biased expression in fat (RPKM 94.8), liver (RPKM 8.9) and 6 other tissues.

功能概要

乙酰辅酶 A 羧化酶 (ACC) 是一种复杂的多功能酶系统。 ACC 是一种含生物素的酶，可催化乙酰辅酶 A 羧化为丙二酰辅酶 A，这是脂肪酸合成中的限速步骤。 ACC-β 被认为通过丙二酰辅酶 A 抑制肉碱-棕榈酰-CoA 转移酶 I 的能力来控制脂肪酸氧化，这是线粒体摄取和氧化脂肪酸的限速步骤。 ACC-β 可能参与脂肪酸氧化的调节，而不是脂肪酸生物合成。[RefSeq 提供，2022 年 10 月]

Acetyl-CoA Carboxylase (ACC) is a complex multifunctional Enzyme system. ACC is a biotin-containing Enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. [provided by RefSeq, Oct 2022]

ACACB 基因产物(9)

mRNA Protein Name
NM_001093.4 NP_001084.3 acetyl-CoA carboxylase 2 isoform a precursor
NM_001412734.1 NP_001399663.1 acetyl-CoA carboxylase 2 isoform a precursor
NM_001412735.1 NP_001399664.1 acetyl-CoA carboxylase 2 isoform a precursor
NM_001412736.1 NP_001399665.1 acetyl-CoA carboxylase 2 isoform b
NM_001412737.1 NP_001399666.1 acetyl-CoA carboxylase 2 isoform c
NM_001412738.1 NP_001399667.1 acetyl-CoA carboxylase 2 isoform d
NM_001412739.1 NP_001399668.1 acetyl-CoA carboxylase 2 isoform e
NM_001412741.1 NP_001399670.1 acetyl-CoA carboxylase 2 isoform f
NM_001412742.1 NP_001399671.1 acetyl-CoA carboxylase 2 isoform g
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables acetyl-CoA carboxylase activity IDA
IDA: 通过直接分析推断
19236960 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20457939 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16794074 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in acetyl-CoA metabolic process IDA
IDA: 通过直接分析推断
20952656 GOA
involved in protein homotetramerization IDA
IDA: 通过直接分析推断
20952656 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrion IDA
IDA: 通过直接分析推断
10677481 GOA
located in nucleus IDA
IDA: 通过直接分析推断
10677481 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ACACB 蛋白结构

Biotin_carb_N

Biotin_carb_N: Biotin carboxylase, N-terminal domain (260 - 379)

CPSase_L_D2

CPSase_L_D2: Carbamoyl-phosphate synthase L chain, ATP binding domain (431 - 614)

Biotin_carb_C

Biotin_carb_C: Biotin carboxylase C-terminal domain (651 - 757)

Biotin_lipoyl

Biotin_lipoyl: Biotin-requiring enzyme (897 - 961)

ACC_central

ACC_central: Acetyl-CoA carboxylase, central region (962 - 1688)

Carboxyl_trans

Carboxyl_trans: Carboxyl transferase domain (1780 - 2333)

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  • 2000
  • 2458 a.a.
蛋白主名 其他名称

acetyl-CoA carboxylase 2

acetyl-Coenzyme A carboxylase beta

ACACB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ACACB O00763 GSK3A Homo sapiens P49840
Anti Tag CoIP
33961781
种属内
ACACB O00763 TACC1 Homo sapiens O75410
Anti Tag CoIP
33961781
种属内
ACACB O00763 ACACA Homo sapiens Q13085
Anti Tag CoIP
33961781
种属内
ACACB O00763 HMGA1 Homo sapiens P17096
Crosslink
30021884
种属内
ACACB O00763 IDS Homo sapiens P22304
Anti Tag CoIP
33961781
种属内
ACACB O00763 GSK3B Homo sapiens P49841
Anti Tag CoIP
33961781
种属内
ACACB O00763 PRKAA1 Homo sapiens Q13131
Anti Tag CoIP
33961781
种属内
ACACB O00763 GRK7 Homo sapiens Q8WTQ7
Anti Tag CoIP
33961781
种属内
ACACB O00763 MID1IP1 Homo sapiens Q9NPA3
Anti Tag CoIP
33961781
种属内
ACACB O00763 ACACB Homo sapiens O00763
GMS
20457939
种属内
ACACB O00763 ACAA1 Homo sapiens P09110
Anti Tag CoIP
33961781
种属内
ACACB O00763 MRPL46 Homo sapiens Q9H2W6
Anti Tag CoIP
33961781
种属内
ACACB O00763 ACACB Homo sapiens O00763
Comig Non-Denat Gel
20457939
种属间: 跨种属相互作用 种属内: 同种属相互作用

ACACB 抗体

目录号 产品名 应用 反应物种
HY-P80528 Acetyl Coenzyme A Carboxylase Antibody WB, IHC-F, IHC-P, ICC/IF Human

关联疾病

疾病名称 别名
Biotin Deficiency

Biotin Deficiency Disease

B7 Deficiency

Biotan Vitamin Deficiency
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00122 ACACB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ACACB MGD MGI:2140940
Bos taurus ACACB VGNC VGNC:25520
Macaca mulatta ACACB VGNC VGNC:99876
Felis catus ACACB VGNC VGNC:68655
Rattus norvegicus ACACB RGD RGD:620500
Canis familiaris ACACB VGNC VGNC:37490
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