2. Gene
  3. HSF2 - heat shock transcription factor 2 Gene

HSF2 - heat shock transcription factor 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：热休克转录因子 2

种属: Homo sapiens

同用名: HSF 2; HSTF 2

基因 ID: 3298 | 基因类型: protein coding

关于 HSF2

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:122,399,551-122,433,119 (from NCBI)

This gene has 3 transcripts (splice variants), 209 orthologues and 9 paralogues. Broad expression in testis (RPKM 22.1), bone marrow (RPKM 8.8) and 23 other tissues.

功能概要

该基因编码的蛋白质属于 HSF 转录因子家族，可特异性结合热休克启动子元件并激活转录。热休克转录因子在热或其他应激条件下激活热休克反应基因。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 7 月]

The protein encoded by this gene belongs to the HSF family of transcription factors that bind specifically to the heat-shock promoter element and activate transcription. Heat shock transcription factors activate heat-shock response genes under conditions of heat or Other stresses. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

HSF2 基因产物(3)

mRNA Protein Name
NM_001135564.1 NP_001129036.1 heat shock factor protein 2 isoform b
NM_001243094.2 NP_001230023.1 heat shock factor protein 2 isoform c
NM_004506.4 NP_004497.1 heat shock factor protein 2 isoform a
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10561509 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
8972228 GOA
enables RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10561509 GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10561509 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25036637 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
10561509 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

HSF2 蛋白结构

HSF_DNA-bind

HSF_DNA-bind: HSF-type DNA-binding (9 - 113)

Vert_HS_TF

Vert_HS_TF: Vertebrate heat shock transcription factor (229 - 512)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 536 a.a.
蛋白主名 其他名称

heat shock factor protein 2

HSF2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
HSF2 Q03933 TPM3 Homo sapiens Q5VU62
Validated Y2H
25416956
种属内
HSF2 Q03933 TPM3 Homo sapiens Q5VU62
Y2H Array
25416956
种属内
HSF2 Q03933 DERA Homo sapiens Q9Y315
Y2H Prey Pooling
32296183
种属内
HSF2 Q03933 DERA Homo sapiens Q9Y315
Validated Y2H
32296183
种属内
HSF2 Q03933 DERA Homo sapiens Q9Y315
Y2H Array
32296183
种属内
HSF2 Q03933 MTUS2 Homo sapiens Q5JR59-3
Y2H Prey Pooling
32296183
种属内
HSF2 Q03933 MTUS2 Homo sapiens Q5JR59-3
Validated Y2H
32296183
种属内
HSF2 Q03933 MTUS2 Homo sapiens Q5JR59-3
Y2H Array
32296183
种属内
HSF2 Q03933 BAG4 Homo sapiens O95429
Anti Tag CoIP
33961781
种属内
HSF2 Q03933 BAG4 Homo sapiens O95429
Lumier
25036637
种属内
HSF2 Q03933 NUP62 Homo sapiens P37198
Y2H Array
31515488
种属内
HSF2 Q03933 NUP62 Homo sapiens P37198
Y2H Prey Pooling
25416956
种属内
HSF2 Q03933 BAG2 Homo sapiens O95816
Lumier
25036637
种属内
HSF2 Q03933 TPM3 Homo sapiens P06753
Y2H Prey Pooling
25416956
种属内
HSF2 Q03933 HSPA2 Homo sapiens P54652
Anti Tag CoIP
33961781
种属内
HSF2 Q03933 WDR5 Homo sapiens P61964
Y2H Array
25416956
种属内
HSF2 Q03933 HSF2BP Homo sapiens O75031
Y2H Array
32296183
种属内
HSF2 Q03933 HSF2BP Homo sapiens O75031
Y2H Prey Pooling
32296183
种属内
HSF2 Q03933 HSF1 Homo sapiens Q00613
Anti Tag CoIP
33961781
种属内
HSF2 Q03933 CEP76 Homo sapiens Q8TAP6
Validated Y2H
32296183
种属内
HSF2 Q03933 CEP76 Homo sapiens Q8TAP6
Y2H Prey Pooling
32296183
种属内
HSF2 Q03933 CEP76 Homo sapiens Q8TAP6
Y2H Array
32296183
种属内
HSF2 Q03933 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
种属内
HSF2 Q03933 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
种属内
HSF2 Q03933 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 HSF2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70406 HSF2 Protein, Human (His) Q03933 (S411-S536) ≥95%

HSF2 抗体

目录号 产品名 应用 反应物种
HY-P82490 Hsf2 Antibody (YA2235) WB, ICC/IF, FC Human

关联疾病

疾病名称 别名
Spermatogenic Failure 10

SPGF10

Spermatogenic Failure With Defective Sperm Annulus
Spermatogenic Failure 14

SPGF14
Erythroleukemia
Spermatogenic Failure 15

SPGF15

Spermatogenic Failure, 15
Spermatogenic Failure, Y-Linked, 2

SPGFY2

Spermatogenic Failure, Nonobstructive, Y-Linked

Y-Linked Spermatogenic Failure 2

Azoospermia, Nonobstructive, Y-Linked

Oligozoospermia, Nonobstructive, Y-Linked

Oligospermia, Nonobstructive, Y-Linked

Spermatogenic Arrest, Y-Linked

Nonobstructive Y-Linked Spermatogenic Failure

Spermatogenic Failure Y-Linked 2

Azoospermia Non-Obstructive Y-Linked

Non-Obstructive Azoospermia And Infertility

Oligospermia Non-Obstructive Y-Linked

Oligozoospermia Non-Obstructive Y-Linked

Spermatogenic Arrest Y-Linked

Spermatogenic Failure Nonobstructive Y-Linked
Spermatogenic Failure

Azoospermia

Spgf

Spermatogenic Failure, Susceptibility To

Absent Sperm

Aspermatogenesis

Infertility Due To Azoospermia

Hypospermatogenesis

Azoospermatism
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06409 HSF2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS06410 HSF2BP Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus HSF2 VGNC VGNC:29982
Canis familiaris HSF2 VGNC VGNC:41815
Felis catus HSF2 VGNC VGNC:67662
Macaca mulatta HSF2 VGNC VGNC:81077
Mus musculus HSF2 MGD MGI:96239
Rattus norvegicus HSF2 RGD RGD:68395
Others HSF2 NCBI
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