2. Gene
  3. ATXN1L - ataxin 1 like Gene

ATXN1L - ataxin 1 like Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：共济失调素 1 样

种属: Homo sapiens

同用名: BOAT; BOAT1

基因 ID: 342371 | 基因类型: protein coding

关于 ATXN1L

Cytogenetic location: 16q22.2 Genomic coordinates (GRCh38): 16:71,845,976-71,857,328 (from NCBI)

This gene has 4 transcripts (splice variants), 184 orthologues and 1 paralogue. Ubiquitous expression in bone marrow (RPKM 17.2), kidney (RPKM 12.6) and 25 other tissues.

功能概要

预测启用 DNA 结合活性和 RNA 结合活性。预计参与多个过程，包括学习或记忆；转录调控，DNA 模板化；和社会行为。预计在几个过程的上游或内部起作用，包括肺泡发育； RNA 聚合酶 II 对转录的负调控；造血干细胞增殖的正调控作用。位于核仁和核质中。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable DNA binding activity and RNA binding activity. Predicted to be involved in several processes, including learning or memory; regulation of transcription, DNA-templated; and social behavior. Predicted to act upstream of or within several processes, including lung alveolus development; negative regulation of transcription by RNA polymerase II; and positive regulation of hematopoietic stem cell proliferation. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ATXN1L 基因产物(1)

mRNA Protein Name
NM_001137675.4 NP_001131147.1 ataxin-1-like
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21475249 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ATXN1L 蛋白结构

AXH

AXH: Ataxin-1 and HBP1 module (AXH) (469 - 581)

  • 0
  • 200
  • 400
  • 600
  • 689 a.a.
蛋白主名 其他名称

ataxin-1-like

brother of ATXN1

ATXN1L 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ATXN1L P0C7T5 FAM22F Homo sapiens B7ZLH0
Y2H Array
32296183
种属内
ATXN1L P0C7T5 FAM22F Homo sapiens B7ZLH0
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 KRTAP19-7 Homo sapiens Q3SYF9
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
32296183
种属内
ATXN1L P0C7T5 KRTAP8-1 Homo sapiens Q8IUC2
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
种属内
ATXN1L P0C7T5 KRTAP11-1 Homo sapiens Q8IUC1
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Array
32296183
种属内
ATXN1L P0C7T5 KRTAP11-1 Homo sapiens Q8IUC1
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 LARP4B Homo sapiens Q92615
Y2H Array
32296183
种属内
ATXN1L P0C7T5 LARP4B Homo sapiens Q92615
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 LARP4B Homo sapiens Q92615
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 PICALM Homo sapiens Q13492-3
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 PICALM Homo sapiens Q13492-3
Y2H Array
32296183
种属内
ATXN1L P0C7T5 PICALM Homo sapiens Q13492-3
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 SHISA2 Homo sapiens Q6UWI4
Y2H Array
32296183
种属内
ATXN1L P0C7T5 SHISA2 Homo sapiens Q6UWI4
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 SHISA2 Homo sapiens Q6UWI4
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 RBFOX2 Homo sapiens O43251-10
Y2H Array
32296183
种属内
ATXN1L P0C7T5 RBFOX2 Homo sapiens O43251-10
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 USP54 Homo sapiens Q70EL1-9
Y2H Array
32296183
种属内
ATXN1L P0C7T5 USP54 Homo sapiens Q70EL1-9
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 USP54 Homo sapiens Q70EL1-9
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 FAM168A Homo sapiens Q92567-2
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 FAM168A Homo sapiens Q92567-2
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 FAM168A Homo sapiens Q92567-2
Y2H Array
32296183
种属内
ATXN1L P0C7T5 RBFOX1 Homo sapiens Q9NWB1-5
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 UNKL Homo sapiens Q9H9P5-5
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 UNKL Homo sapiens Q9H9P5-5
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 UNKL Homo sapiens Q9H9P5-5
Y2H Array
32296183
种属内
ATXN1L P0C7T5 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 a0a1u9x8x8_human Homo sapiens A0A1U9X8X8
Y2H Array
32296183
种属内
ATXN1L P0C7T5 FOXH1 Homo sapiens O75593
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 FOXH1 Homo sapiens O75593
Y2H Array
32296183
种属内
ATXN1L P0C7T5 KRTAP21-2 Homo sapiens Q3LI59
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 KRTAP21-2 Homo sapiens Q3LI59
Y2H Array
32296183
种属内
ATXN1L P0C7T5 KRTAP21-2 Homo sapiens Q3LI59
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 MEIS3 Homo sapiens Q99687-3
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 MEIS3 Homo sapiens Q99687-3
Y2H Array
32296183
种属内
ATXN1L P0C7T5 MEIS3 Homo sapiens Q99687-3
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 TBX2 Homo sapiens Q13207
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 TBX2 Homo sapiens Q13207
Y2H Array
32296183
种属内
ATXN1L P0C7T5 TBX2 Homo sapiens Q13207
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 MYOZ3 Homo sapiens Q8TDC0
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 RBPJ Homo sapiens Q06330
Y2H
21475249
种属内
ATXN1L P0C7T5 RBPJ Homo sapiens Q06330
Pull Down
21475249
种属内
ATXN1L P0C7T5 RBPJ Homo sapiens Q06330
Anti Tag CoIP
21475249
种属内
ATXN1L P0C7T5 HLX Homo sapiens Q14774
Y2H Array
32296183
种属内
ATXN1L P0C7T5 HLX Homo sapiens Q14774
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 HLX Homo sapiens Q14774
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 AGXT Homo sapiens P21549
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 SPMIP9 Homo sapiens Q96LM6
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 SPMIP9 Homo sapiens Q96LM6
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 SPMIP9 Homo sapiens Q96LM6
Y2H Array
32296183
种属内
ATXN1L P0C7T5 METTL27 Homo sapiens Q8N6F8
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 METTL27 Homo sapiens Q8N6F8
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 METTL27 Homo sapiens Q8N6F8
Y2H Array
32296183
种属内
ATXN1L P0C7T5 C1orf94 Homo sapiens Q6P1W5
Y2H Array
32296183
种属内
ATXN1L P0C7T5 C1orf94 Homo sapiens Q6P1W5
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 C1orf94 Homo sapiens Q6P1W5
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 ARID5A Homo sapiens Q03989
Y2H Prey Pooling
32296183
种属内
ATXN1L P0C7T5 ARID5A Homo sapiens Q03989
Validated Y2H
32296183
种属内
ATXN1L P0C7T5 ARID5A Homo sapiens Q03989
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Spinocerebellar Ataxia 1

Spinocerebellar Ataxia Type 1

SCA1

Olivopontocerebellar Atrophy I

Opca1

Opca4

Menzel Type Opca

Schut-Haymaker Type Opca

Spinocerebellar Atrophy I

Opca I

Olivopontocerebellar Atrophy Iv

Opca Iv

Cerebelloparenchymal Disorder I

Cpd1

Olivopontocerebellar Atrophy 1

Cerebelloparenchymal Disorder 1

Olivopontocerebellar Atrophy 4

Spinocerebellar Atrophy 1

Type 1 Spinocerebellar Ataxia

Spinocerebellar Ataxia-1

Ataxia, Spinocerebellar, Type 1
Omphalocele

Omphalocoele

Congenital Omphalocele

Exomphalos

Exumbilication
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01255 ATXN1L Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ATXN1L MGD MGI:3694797
Canis familiaris ATXN1L VGNC VGNC:38300
Rattus norvegicus ATXN1L RGD RGD:9319286
Macaca mulatta ATXN1L VGNC VGNC:99486
Bos taurus ATXN1L VGNC VGNC:26339
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z