AQP8 - aquaporin 8 Gene

中文名称：水通道蛋白 8

种属: Homo sapiens

同用名: AQP-8

基因 ID: 343 | 基因类型: protein coding

关于 AQP8

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:25,216,947-25,228,932 (from NCBI)

This gene has 2 transcripts (splice variants), 201 orthologues and 11 paralogues. Restricted expression toward colon (RPKM 257.9).

功能概要

水通道蛋白 8 (AQP8) 是一种水通道蛋白。水通道蛋白是与主要内在蛋白 (MIP 或 AQP0) 相关的小型整合膜蛋白家族。水通道蛋白 8 mRNA 存在于胰腺和结肠中，但不存在于其他组织中。[RefSeq 提供，2008 年 7 月]

Aquaporin 8 (AQP8) is a water channel protein. Aquaporins are a family of small integral membrane proteins related to the major intrinsic protein (MIP or AQP0). Aquaporin 8 mRNA is found in pancreas and colon but not other tissues. [provided by RefSeq, Jul 2008]

AQP8 基因产物(1)

mRNA	Protein	Name
NM_001169.3	NP_001160.2	aquaporin-8

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables methylammonium channel activity	IDA IDA: 通过直接分析推断	15948717	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	32296183	GOA
enables water channel activity	IDA IDA: 通过直接分析推断	15948717	GOA
enables water channel activity	IMP IMP: 通过突变表型推断	18948439	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in ammonium transmembrane transport	IMP IMP: 通过突变表型推断	22622463	GOA
involved in cellular detoxification	IMP IMP: 通过突变表型推断	34292591	GOA
involved in cellular response to cAMP	IEP IEP: 通过表达模式推断	17636236	GOA
involved in hydrogen peroxide transmembrane transport	IMP IMP: 通过突变表型推断	23541115	GOA
involved in methylammonium transport	IDA IDA: 通过直接分析推断	15948717	GOA
involved in regulation of cholesterol biosynthetic process	IMP IMP: 通过突变表型推断	30579780	GOA
involved in water transport	IDA IDA: 通过直接分析推断	15948717	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in apical part of cell	IDA IDA: 通过直接分析推断	12801959	GOA
located in intracellular canaliculus	IDA IDA: 通过直接分析推断	18948439	GOA
located in mitochondrial inner membrane	IDA IDA: 通过直接分析推断	22622463	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AQP8 蛋白结构

MIP

0
100
200
261 a.a.

蛋白主名

其他名称

aquaporin-8

AQP8 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	AQP8	O94778	SERP1	Homo sapiens	Q9Y6X1	Validated Y2H	32296183
Intra	AQP8	O94778	KIF1B	Homo sapiens	O60333-2	Validated Y2H	32814053
Intra	AQP8	O94778	KIF1B	Homo sapiens	O60333-2	Y2H Array	32814053
Intra	AQP8	O94778	KIF1B	Homo sapiens	O60333-2	Y2H Pooling	32814053
Intra	AQP8	O94778	BAG6	Homo sapiens	P46379-2	Validated Y2H	32814053
Intra	AQP8	O94778	BAG6	Homo sapiens	P46379-2	Y2H Array	32814053
Intra	AQP8	O94778	BAG6	Homo sapiens	P46379-2	Y2H Pooling	32814053
Intra	AQP8	O94778	PLPP6	Homo sapiens	Q8IY26	Validated Y2H	32296183
Intra	AQP8	O94778	DNAJB6	Homo sapiens	O75190-2	Y2H Pooling	32814053
Intra	AQP8	O94778	DNAJB6	Homo sapiens	O75190-2	Validated Y2H	32814053
Intra	AQP8	O94778	DNAJB6	Homo sapiens	O75190-2	Y2H Array	32814053
Intra	AQP8	O94778	CYBC1	Homo sapiens	Q9BQA9	Validated Y2H	32296183
Intra	AQP8	O94778	STX12	Homo sapiens	Q86Y82	Validated Y2H	32296183
Intra	AQP8	O94778	HSPB1	Homo sapiens	P04792	Y2H Pooling	32814053
Intra	AQP8	O94778	HSPB1	Homo sapiens	P04792	Validated Y2H	32814053
Intra	AQP8	O94778	HSPB1	Homo sapiens	P04792	Y2H Array	32814053
Intra	AQP8	O94778	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	AQP8	O94778	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	AQP8	O94778	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	AQP8	O94778	PLP2	Homo sapiens	Q04941	Validated Y2H	32296183
Intra	AQP8	O94778	WFS1	Homo sapiens	O76024	Y2H Array	32814053
Intra	AQP8	O94778	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	AQP8	O94778	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	AQP8	O94778	PRPS1	Homo sapiens	P60891	Validated Y2H	32814053
Intra	AQP8	O94778	PRPS1	Homo sapiens	P60891	Y2H Pooling	32814053
Intra	AQP8	O94778	PRPS1	Homo sapiens	P60891	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Polyhydramnios

Palmoplantar Keratoderma, Bothnian Type

PPKB	Diffuse Palmoplantar Keratoderma, Bothnian Type
Bothnian Type Palmoplantar Keratoderma	Keratoderma, Palmoplantar, Bothnian Type
Palmoplantar Keratoderma, Nonepidermolytic

Crohn'S Colitis

Crohn Disease

Nephrogenic Diabetes Insipidus

Vasopressin-Resistant Diabetes Insipidus	Diabetes Insipidus, Nephrogenic
Diabetes Insipidus Nephrogenic	Congenital Nephrogenic Diabetes Insipidus
Adh Resistant Diabetes Insipidus	Diabetes Insipidus Nephrogenic X-Linked
Diabetes Insipidus Nephrogenic Type 1	Adh-Resistant Diabetes Insipidus
Diabetes Insipidus Renalis	Ndi
Renal Diabetes Insipidus	Familial Nephrogenic Diabetes
Antidiuretic-Hormone-Resistant Diabetes Insipidus	Adiuretin-Resistant Diabetes Insipidus
Ndi - [Nephrogenic Diabetes Insipidus]	Diabetes Tenuifluus
Adh - [Antidiuretic-Hormone] Resistant Diabetes Insipidus	Hereditary Nephrogenic Diabetes Insipidus
Familial Nephrogenic Diabetes Insipidus	Primary Nephrogenic Diabetes Insipidus

Oligohydramnios

Oligohydramnios - Delivered	Antepartum Oligohydramnios
Delivered Oligohydramnios	Oligohydramnios, Antepartum Condition Or Complication
Deficient Liquor	Oligohydramnios, Unspecified Trimester
Reduced Liquor Volume

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00880	AQP8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Canis familiaris	AQP8	VGNC	VGNC:38020
Felis catus	AQP8	VGNC	VGNC:67985
Macaca mulatta	AQP8	VGNC	VGNC:69995
Bos taurus	AQP8	VGNC	VGNC:26050
Mus musculus	AQP8	MGD	MGI:1195271
Rattus norvegicus	AQP8	RGD	RGD:2146

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

AQP8 - aquaporin 8 Gene

关于 AQP8

功能概要

AQP8 基因产物(1)

AQP8 蛋白结构

AQP8 蛋白互作信息

关联疾病

直系同源

热门区域

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AQP8 - aquaporin 8 Gene

关于 AQP8

功能概要

AQP8 基因产物(1)

AQP8 蛋白结构

AQP8 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z