Yap1 - Yes1 associated transcriptional regulator Gene

中文名称：Yes1 相关的转录调节因子

种属: Rattus norvegicus

同用名: Yap; YAP65

关于 Yap1

功能概要

预计该基因编码的蛋白可启动多种功能，包括富含脯氨酸的区域结合活动；蛋白 C 端结合活性；和转录共激活因子活性。预计参与多个过程，包括细胞群增殖的正调控；基因表达的调节；和对类固醇激素的反应。预计在几个过程的上游或内部起作用，包括动物器官发育；上皮细胞分化的调节；和信号转导的调节。预测位于胞质溶胶中；雌性生殖细胞核；和膜。预计成为 TEAD-YAP 复合体的一部分。预计在细胞质和细胞核中有活性。该基因的人类直系同源物与葡萄膜缺损-唇裂和腭裂-智力障碍有关。与人类 YAP1（Yes1 相关转录调节因子）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including proline-rich region binding activity; protein C-terminus binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including positive regulation of cell population proliferation; regulation of gene expression; and response to steroid hormone. Predicted to act upstream of or within several processes, including animal organ development; regulation of epithelial cell differentiation; and regulation of signal transduction. Predicted to be located in cytosol; female germ cell nucleus; and membrane. Predicted to be part of TEAD-YAP complex. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in uveal coloboma-cleft lip and palate-intellectual disability. Orthologous to human YAP1 (Yes1 associated transcriptional regulator). [provided by Alliance of Genome Resources, Apr 2022]