2. Gene
  3. IRF5 - interferon regulatory factor 5 Gene

IRF5 - interferon regulatory factor 5 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：干扰素调节因子 5

种属: Homo sapiens

同用名: SLEB10

基因 ID: 3663 | 基因类型: protein coding

关于 IRF5

Cytogenetic location: 7q32.1 Genomic coordinates (GRCh38): 7:128,937,032-128,950,038 (from NCBI)

This gene has 22 transcripts (splice variants), 218 orthologues, 8 paralogues and is associated with 8 phenotypes. Broad expression in spleen (RPKM 8.6), lymph node (RPKM 6.5) and 25 other tissues.

功能概要

该基因编码干扰素调节因子 (IRF) 家族的一个成员，该家族是一组具有不同作用的转录因子，包括病毒介导的干扰素激活以及细胞生长、分化、凋亡和免疫系统活性的调节。 IRF 家族成员的特征是包含色氨酸 (W) 重复序列的保守 N 端 DNA 结合域。替代启动子的使用和替代剪接会导致多个转录变体，而 30-nt 插入缺失多态性 (SNP rs60344245) 会导致 10-aa 片段丢失。[RefSeq 提供，2016 年 12 月]

This gene encodes a member of the interferon regulatory factor (IRF) family, a group of transcription factors with diverse roles, including virus-mediated activation of interferon, and modulation of cell growth, differentiation, Apoptosis, and immune system activity. Members of the IRF family are characterized by a conserved N-terminal DNA-binding domain containing tryptophan (W) repeats. Alternative promoter use and alternative splicing result in multiple transcript variants, and a 30-nt indel polymorphism (SNP rs60344245) can result in loss of a 10-aa segment. [provided by RefSeq, Dec 2016]

IRF5 基因产物(7)

mRNA Protein Name
NM_001098627.4 NP_001092097.2 interferon regulatory factor 5 isoform b
NM_001098629.3 NP_001092099.1 interferon regulatory factor 5 isoform d
NM_001098630.3 NP_001092100.1 interferon regulatory factor 5 isoform b
NM_001242452.3 NP_001229381.1 interferon regulatory factor 5 isoform e
NM_001347928.2 NP_001334857.1 interferon regulatory factor 5 isoform d
NM_001364314.2 NP_001351243.1 interferon regulatory factor 5 isoform d
NM_032643.5 NP_116032.1 interferon regulatory factor 5 isoform b
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
12600985 GOA
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
25326418 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
18836453 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18836453 GOA
enables protein kinase binding IPI
IPI: 通过物理相互作用推断
25326418 GOA
enables sequence-specific DNA binding IMP
IMP: 通过突变表型推断
23332764 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to virus IDA
IDA: 通过直接分析推断
29046356 GOA
involved in cytokine-mediated signaling pathway IDA
IDA: 通过直接分析推断
25326418 GOA
involved in positive regulation of apoptotic process IMP
IMP: 通过突变表型推断
22412986 GOA
involved in positive regulation of cytokine production involved in immune response IDA
IDA: 通过直接分析推断
29046356 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
12600985 GOA
involved in positive regulation of type I interferon production IDA
IDA: 通过直接分析推断
32433612 GOA
involved in response to muramyl dipeptide IDA
IDA: 通过直接分析推断
22412986 GOA
involved in response to peptidoglycan IDA
IDA: 通过直接分析推断
22412986 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
22412986 GOA
located in nucleus IDA
IDA: 通过直接分析推断
22412986 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IRF5 蛋白结构

IRF

IRF: Interferon regulatory factor transcription factor (14 - 122)

IRF-3

IRF-3: Interferon-regulatory factor 3 (248 - 431)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 498 a.a.
蛋白主名 其他名称

interferon regulatory factor 5

重组 IRF5 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70573 IRF5 Protein, Human Q13568-1 (M1-Q498) ≥95%

关联疾病

疾病名称 别名
Systemic Lupus Erythematosus 10

Systemic Lupus Erythematosus, Susceptibility To, 10

SLEB10

Lupus Erythematosus, Systemic, Type 10
Inflammatory Bowel Disease 14

IBD14

Inflammatory Bowel Disease 14, Susceptibility To

Bowel Disease, Inflammatory, Type 14
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Limited Scleroderma

Limited Cutaneous Systemic Sclerosis

Limited Systemic Sclerosis

Systemic Sclerosis Sine Scleroderma

Crest Syndrome

Limited Cutaneous Systemic Scleroderma

Scleroderma, Limited

Systemic Sclerosis, Limited

Progressive Systemic Sclerosis Sine Scleroderma

Scleroderma, Sine

Crest - [Calcinosis, Raynaud Phenomenon, Oesophageal Dysmotility, Sclerodactyly, And Telangiectasia] Syndrome

Crst - [Calcinosis, Raynaud Phenomenon, Sclerodactyly And Telangiectasia] Syndrome
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Diffuse Cutaneous Systemic Sclerosis

Diffuse Cutaneous Systemic Scleroderma

Progressive Cutaneous Systemic Scleroderma

Progressive Cutaneous Systemic Sclerosis

Dcssc

Diffuse Scleroderma
Primary Biliary Cholangitis

Primary Biliary Cirrhosis

Biliary Liver Cirrhosis

Chronic Nonsuppurative Destructive Cholangitis

Familial Primary Biliary Cirrhosis

Pbc

Hanot Syndrome

Cholestatic Cirrhosis

Biliary Cirrhosis Primary

Liver Cirrhosis, Biliary

Hanot'S Cirrhosis

Biliary Cirrhosis

Pericholangiolic Biliary Cirrhosis

Tannhauser-Magendantz Syndrome

Hanot-Rossle Syndrome

Hypertrophic Cirrhosis

Todd Cirrhosis

Hanot Cirrhosis

Charcot Cirrhosis

Mahon-Tannhauser Syndrome

Toxic Cirrhosis

Hypertrophic Biliary Cirrhosis

Monolobular Cirrhosis

Unilobar Cirrhosis

Xanthomatous Biliary Cirrhosis
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]
Ulcerative Colitis

Colitis Gravis

Left Sided Ulcerative Colitis

Left-Sided Ulcerative Colitis

Idiopathic Proctocolitis

Inflammatory Bowel Disease, Ulcerative Colitis Type

Uc

Colitis Ulcerative

Colitis, Ulcerative

Chronic Left-Sided Ulcerative Colitis

Uc - [Ulcerative Colitis]

Chronic Ulcerative Enteritis

Mucosal Proctocolitis

Ulcerative Mucosal Proctocolitis

Left Hemicolitis
Colitis
Autoimmune Disease

Autoimmune Diseases

Autoimmune Hypersensitivity Disease

Hypersensitivity Reaction Type Ii Disease

Type Ii Hypersensitivity Reaction Disease
Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory
Systemic Scleroderma

Scleroderma

Progressive Systemic Sclerosis

Systemic Sclerosis

Scleroderma, Systemic

Scleroderma Syndrome

Dermatosclerosis

Familial Progressive Scleroderma

Progressive Scleroderma

Scleroderma Disease

Scleroderma, Localized

Diffuse Scleroderma

Scleroderma, Familial Progressive
Macrophage Activation Syndrome
Autoimmune Disease Of Exocrine System
Chilblain Lupus 1

Chilblain Lupus

CHBL1

Chilblain Lupus Erythematosus

Chle

Hutchinson Lupus

Chilblain Lupus, Type 1
Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS
Cutaneous Lupus Erythematosus

Lupus Erythematosus, Cutaneous

Lupus Erythematosus Cutaneous
Uterine Adnexa Cancer
Aicardi-Goutieres Syndrome

Aicardi Goutieres Syndrome

Cree Encephalitis

Aicardi-Goutières Syndrome

Encephalopathy With Basal Ganglia Calcification

Ags

Encephalopathy With Intracranial Calcification And Chronic Lymphocytosis Of Cerebrospinal Fluid

Pseudotoxoplasmosis Syndrome

Encephalopathy, Familial Infantile, With Calcification Of Basal Ganglia And Chronic Cerebrospinal Fluid Lymphocytosis

Familial Infantile Encephalopathy With Intracranial Calcification And Chronic Cerebrospinal Fluid Lymphocytosis

Aicardi-Goutieres Syndrome 1
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-149652 IRF5-IN-1 99.91% 否
HY-150095 YE6144 Inhibitor 99.86% 否
HY-RS06909 IRF5 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus IRF5 RGD RGD:1310447
Macaca mulatta IRF5 VGNC VGNC:73763
Canis familiaris IRF5 VGNC VGNC:42094
Felis catus IRF5 VGNC VGNC:67827
Mus musculus IRF5 MGD MGI:1350924
Bos taurus IRF5 VGNC VGNC:30276
Others IRF5 NCBI
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