2. Gene
  3. ITPKB - inositol-trisphosphate 3-kinase B Gene

ITPKB - inositol-trisphosphate 3-kinase B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：肌醇三磷酸 3-激酶 B

种属: Homo sapiens

同用名: IP3K; IP3KB; PIG37; IP3K-B; IP3-3KB

基因 ID: 3707 | 基因类型: protein coding

关于 ITPKB

Cytogenetic location: 1q42.12 Genomic coordinates (GRCh38): 1:226,631,690-226,739,282 (from NCBI)

This gene has 3 transcripts (splice variants), 206 orthologues and 6 paralogues. Ubiquitous expression in brain (RPKM 10.0), fat (RPKM 9.3) and 24 other tissues.

功能概要

由该蛋白编码的蛋白通过将第二信使肌醇 1,4,5-三磷酸磷酸化为 Ins (1,3,4,5) P4 来调节肌醇磷酸代谢。这种编码蛋白的活性负责调节大量在细胞信号传导中很重要的肌醇多磷酸盐的水平。钙/钙调蛋白和蛋白质磷酸化机制均控制其活性。[RefSeq 提供，2008 年 7 月]

The protein encoded by this protein regulates inositol phosphate metabolism by phosphorylation of second messenger inositol 1,4,5-trisphosphate to Ins(1,3,4,5)P4. The activity of this encoded protein is responsible for regulating the levels of a large number of inositol polyphosphates that are important in cellular signaling. Both calcium/Calmodulin and protein phosphorylation mechanisms control its activity. [provided by RefSeq, Jul 2008]

ITPKB 基因产物(2)

mRNA Protein Name
NM_001388404.1 NP_001375333.1 inositol-trisphosphate 3-kinase B isoform 2
NM_002221.4 NP_002212.3 inositol-trisphosphate 3-kinase B isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables inositol-1,4,5-trisphosphate 3-kinase activity IDA
IDA: 通过直接分析推断
1654894 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
21516116 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to calcium ion IDA
IDA: 通过直接分析推断
1654894 GOA
involved in inositol trisphosphate metabolic process IDA
IDA: 通过直接分析推断
1654894 GOA
involved in phosphatidylinositol phosphate biosynthetic process IDA
IDA: 通过直接分析推断
12747803 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
12747803 GOA
located in cytoskeleton IDA
IDA: 通过直接分析推断
12747803 GOA
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
12747803 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ITPKB 蛋白结构

IPK

IPK: Inositol polyphosphate kinase (726 - 936)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 946 a.a.
蛋白主名 其他名称

inositol-trisphosphate 3-kinase B

IP3 3-kinase B

ITPKB 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ITPKB P27987 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra ITPKB P27987 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra ITPKB P27987 PPP3CA Homo sapiens Q08209-2
Validated Y2H
32296183
Intra ITPKB P27987 PPP3CA Homo sapiens Q08209-2
Y2H Array
32296183
Intra ITPKB P27987 PPP3CA Homo sapiens Q08209-2
Y2H Prey Pooling
32296183
Intra ITPKB P27987 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
Intra ITPKB P27987 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
Intra ITPKB P27987 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
Intra ITPKB P27987 IFT88 Homo sapiens Q13099
Y2H Array
32296183
Intra ITPKB P27987 IFT88 Homo sapiens Q13099
Y2H Prey Pooling
32296183
Intra ITPKB P27987 IFT88 Homo sapiens Q13099
Validated Y2H
32296183
Intra ITPKB P27987 SCAI Homo sapiens Q8N9R8
Validated Y2H
32296183
Intra ITPKB P27987 SCAI Homo sapiens Q8N9R8
Y2H Array
32296183
Intra ITPKB P27987 SCAI Homo sapiens Q8N9R8
Y2H Prey Pooling
32296183
Intra ITPKB P27987 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
25416956
Intra ITPKB P27987 GOLGA2 Homo sapiens Q08379
Y2H Array
25416956
Intra ITPKB P27987 GOLGA2 Homo sapiens Q08379
Validated Y2H
25416956
Intra ITPKB P27987 CEP70 Homo sapiens Q8NHQ1
Y2H Prey Pooling
32296183
Intra ITPKB P27987 CEP70 Homo sapiens Q8NHQ1
Validated Y2H
32296183
Intra ITPKB P27987 CEP70 Homo sapiens Q8NHQ1
Y2H Array
32296183
Intra ITPKB P27987 CTDSP1 Homo sapiens Q9GZU7
Validated Y2H
32296183
Intra ITPKB P27987 CTDSP1 Homo sapiens Q9GZU7
Y2H Array
32296183
Intra ITPKB P27987 CTDSP1 Homo sapiens Q9GZU7
Y2H Prey Pooling
32296183
Intra ITPKB P27987 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra ITPKB P27987 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Intra ITPKB P27987 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Maxillary Cancer

Maxillary Neoplasm

Maxillary Neoplasms

Upper Jaw Bone Cancer
Combined Immunodeficiency

Combined T Cell And B Cell Immunodeficiency

Congenital Combined Immunodeficiency

Syndrome With Combined Immunodeficiency

Combined T And B Cell Immunodeficiency

Combined Immunity Deficiency

Combined Immunodeficiency Syndrome

Combined T-Cell And B-Cell Immunodeficiency

Lymphopenic Agammaglobulinaemia
Severe Combined Immunodeficiency

Scid

Severe Combined Immunodeficiency Disease

Combined T And B Cell Inborn Immunodeficiency

Immunodeficiency, Severe Combined

Scid - [Severe Combined Immunodeficiencies]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126750 GNF362 Inhibitor 99.63% 否
HY-RS06989 ITPKB Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ITPKB MGD MGI:109235
Canis familiaris ITPKB VGNC VGNC:42155
Macaca mulatta ITPKB VGNC VGNC:106392
Rattus norvegicus ITPKB RGD RGD:2932
Felis catus ITPKB VGNC VGNC:67868
Bos taurus ITPKB VGNC VGNC:106787
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