CATIP - ciliogenesis associated TTC17 interacting protein Gene

中文名称：纤毛发生相关的 TTC17 相互作用蛋白

种属: Homo sapiens

同用名: C2orf62

基因 ID: 375307 | 基因类型: protein coding

关于 CATIP

Cytogenetic location: 2q35 Genomic coordinates (GRCh38): 2:218,356,857-218,368,094 (from NCBI)

This gene has 5 transcripts (splice variants), 183 orthologues, 1 paralogue and is associated with 1 phenotype. Biased expression in testis (RPKM 1.8), kidney (RPKM 1.1) and 13 other tissues.

功能概要

参与肌动蛋白丝聚合和纤毛组织。位于几种细胞成分中，包括肌动蛋白细胞骨架；核;和质膜。与生精失败有关。 [由基因组资源联盟提供，2022 年 4 月]

Involved in actin filament polymerization and cilium organization. Located in several cellular components, including actin cytoskeleton; nucleus; and plasma membrane. Implicated in spermatogenic failure. [provided by Alliance of Genome Resources, Apr 2022]

CATIP 基因产物(2)

mRNA	Protein	Name
NM_001320865.2	NP_001307794.1	ciliogenesis-associated TTC17-interacting protein isoform 1
NM_198559.2	NP_940961.1	ciliogenesis-associated TTC17-interacting protein isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables protein binding	IPI IPI: 通过物理相互作用推断	24475127	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in actin filament polymerization	IDA IDA: 通过直接分析推断	32503832	GOA
involved in actin filament polymerization	IMP IMP: 通过突变表型推断	24475127	GOA
involved in cilium organization	IMP IMP: 通过突变表型推断	24475127	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in actin cytoskeleton	IDA IDA: 通过直接分析推断	24475127	GOA
located in cytoplasm	IDA IDA: 通过直接分析推断	24475127	GOA
located in nucleus	IDA IDA: 通过直接分析推断	24475127	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	24475127	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

ciliogenesis-associated TTC17-interacting protein

CATIP 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
Intra	CATIP	Q7Z7H3	KRT40	Homo sapiens	Q6A162	Validated Y2H	25416956
Intra	CATIP	Q7Z7H3	KRT40	Homo sapiens	Q6A162	Y2H Prey Pooling	25416956
Intra	CATIP	Q7Z7H3	KRTAP10-9	Homo sapiens	P60411	Y2H Array	25416956
Intra	CATIP	Q7Z7H3	KRTAP10-7	Homo sapiens	P60409	Validated Y2H	25416956
Intra	CATIP	Q7Z7H3	KRTAP10-7	Homo sapiens	P60409	Y2H Array	25416956
Intra	CATIP	Q7Z7H3	KRTAP10-7	Homo sapiens	P60409	Y2H Prey Pooling	25416956
Intra	CATIP	Q7Z7H3	BRD9	Homo sapiens	Q9H8M2	Validated Y2H	25416956
Intra	CATIP	Q7Z7H3	MEDAG	Homo sapiens	Q5VYS4	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	MEDAG	Homo sapiens	Q5VYS4	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	BRD9	Homo sapiens	Q9H8M2-3	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	BRD9	Homo sapiens	Q9H8M2-3	Validated Y2H	32296183
Intra	CATIP	Q7Z7H3	BRD9	Homo sapiens	Q9H8M2-3	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	CYSRT1	Homo sapiens	A8MQ03	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	CYSRT1	Homo sapiens	A8MQ03	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	CEP72	Homo sapiens	Q9P209	Y2H Array	25416956
Intra	CATIP	Q7Z7H3	DDIT4L	Homo sapiens	Q96D03	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	DDIT4L	Homo sapiens	Q96D03	Validated Y2H	32296183
Intra	CATIP	Q7Z7H3	MTUS2	Homo sapiens	Q5JR59	Y2H Prey Pooling	25416956
Intra	CATIP	Q7Z7H3	MTUS2	Homo sapiens	Q5JR59	Y2H Array	25416956
Intra	CATIP	Q7Z7H3	CTNNBL1	Homo sapiens	Q8WYA6	Y2H Prey Pooling	25416956
Intra	CATIP	Q7Z7H3	HESX1	Homo sapiens	Q9UBX0	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	HESX1	Homo sapiens	Q9UBX0	Validated Y2H	32296183
Intra	CATIP	Q7Z7H3	HESX1	Homo sapiens	Q9UBX0	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	KRT31	Homo sapiens	Q15323	Y2H Array	32296183
Intra	CATIP	Q7Z7H3	KRT31	Homo sapiens	Q15323	Validated Y2H	25416956
Intra	CATIP	Q7Z7H3	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	32296183
Intra	CATIP	Q7Z7H3	KRT31	Homo sapiens	Q15323	Y2H Prey Pooling	25416956
Intra	CATIP	Q7Z7H3	KRT31	Homo sapiens	Q15323	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Spermatogenic Failure 54

SPGF54

Spermatogenic Failure

Azoospermia	Spgf
Spermatogenic Failure, Susceptibility To	Absent Sperm
Aspermatogenesis	Infertility Due To Azoospermia
Hypospermatogenesis	Azoospermatism

Melnick-Needles Syndrome

MNS	Melnick-Needles Osteodysplasty
Osteodysplasty Of Melnick And Needles	Osteochondrodysplasias

Male Infertility

Infertility, Male	Infertility Male
Male Sterility	Absolute Infertility

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS01983	CATIP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CATIP	RGD	RGD:1596071
Mus musculus	CATIP	MGD	MGI:2685062
Bos taurus	CATIP	VGNC	VGNC:26793
Canis familiaris	CATIP	VGNC	VGNC:57375
Felis catus	CATIP	VGNC	VGNC:60392
Macaca mulatta	CATIP	VGNC	VGNC:70624

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