2. Gene
  3. BRD9 - bromodomain containing 9 Gene

BRD9 - bromodomain containing 9 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含溴结构域 9

种属: Homo sapiens

同用名: PRO9856; SMARCI2; LAVS3040

基因 ID: 65980 | 基因类型: protein coding

关于 BRD9

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:863,735-892,801 (from NCBI)

This gene has 19 transcripts (splice variants), 203 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 6.5), lymph node (RPKM 4.8) and 25 other tissues.

功能概要

启用赖氨酸乙酰化组蛋白结合活性。预计参与 RNA 聚合酶 II 的转录调控。位于核质中。 SWI/SNF 复合体的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables lysine-acetylated histone binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of SWI/SNF complex. [provided by Alliance of Genome Resources, Apr 2022]

BRD9 基因产物(25)

mRNA Protein Name
XM_047417603.1 XP_047273559.1 bromodomain-containing protein 9 isoform X5
NR_134296.1
XM_024446198.2 XP_024301966.1 bromodomain-containing protein 9 isoform X9
XM_047417606.1 XP_047273562.1 bromodomain-containing protein 9 isoform X12
NM_023924.5 NP_076413.3 bromodomain-containing protein 9 isoform 1
NM_001375877.1 NP_001362806.1 bromodomain-containing protein 9 isoform 7
XM_024446199.2 XP_024301967.1 bromodomain-containing protein 9 isoform X7
XM_047417602.1 XP_047273558.1 bromodomain-containing protein 9 isoform X4
NM_001375863.1 NP_001362792.1 bromodomain-containing protein 9 isoform 6
XM_047417605.1 XP_047273561.1 bromodomain-containing protein 9 isoform X10
XM_024446196.2 XP_024301964.1 bromodomain-containing protein 9 isoform X3
NM_001317951.2 NP_001304880.1 bromodomain-containing protein 9 isoform 3
NM_001375862.1 NP_001362791.1 bromodomain-containing protein 9 isoform 5
NM_001009877.3 NP_001009877.2 bromodomain-containing protein 9 isoform 2
XM_047417600.1 XP_047273556.1 bromodomain-containing protein 9 isoform X1
NM_001375878.1 NP_001362807.1 bromodomain-containing protein 9 isoform 8
XR_007058631.1
XM_047417601.1 XP_047273557.1 bromodomain-containing protein 9 isoform X2
XM_006714494.4 XP_006714557.1 bromodomain-containing protein 9 isoform X11
XM_024446195.2 XP_024301963.1 bromodomain-containing protein 9 isoform X1
XM_024446200.2 XP_024301968.1 bromodomain-containing protein 9 isoform X8
XM_047417604.1 XP_047273560.1 bromodomain-containing protein 9 isoform X6
NR_164742.1
NM_001375879.1 NP_001362808.1 bromodomain-containing protein 9 isoform 9
NM_001375861.1 NP_001362790.1 bromodomain-containing protein 9 isoform 4
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables lysine-acetylated histone binding IDA
IDA: 通过直接分析推断
22464331 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of SWI/SNF complex IDA
IDA: 通过直接分析推断
23644491 GOA
located in nucleus IDA
IDA: 通过直接分析推断
25593309 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

BRD9 蛋白结构

Bromodomain

Bromodomain: Bromodomain (147 - 228)

DUF3512

DUF3512: Domain of unknown function (DUF3512) (268 - 505)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 597 a.a.
蛋白主名 其他名称

bromodomain-containing protein 9

rhabdomyosarcoma antigen MU-RMS-40.8

sarcoma antigen NY-SAR-29

BRD9 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra BRD9 Q9H8M2 CATIP Homo sapiens Q7Z7H3
Y2H Array
25416956
Intra BRD9 Q9H8M2 CATIP Homo sapiens Q7Z7H3
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nut Midline Carcinoma

Nuclear Protein In Testis Midline Carcinoma

Nmc
Chronic Dacryoadenitis
Sarcoma, Synovial

Synovial Sarcoma

Synovialosarcoma

Synovial Cell Sarcoma

Sarcoma Synovial
Sarcoma

Connective And Soft Tissue Neoplasm

Tumor Of Soft Tissue And Skeleton

Sarcomas

Sarcoma - Category
Rhabdoid Cancer

Rhabdoid Tumor

Malignant Rhabdoid Tumor

Malignant Rhabdoid Tumour

Rhabdoid Sarcoma

Rhabdoid Tumor Predisposition Syndrome 1

Rhabdoid Tumor Predisposition Syndrome 2

Atypical Teratoid Rhabdoid Tumor

Brain Tumor, Posterior Fossa, Of Infancy, Familial

Atypical Teratoid/Rhabdoid Tumor
Synovium Cancer

Malignant Tumor Of Synovium

Synovial Neoplasm
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-153367 FHD-609 Inhibitor 99.15% Phase 1
Pre-clinical Phase
生物活性分子 (18)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-114322 VZ185 Inhibitor 98.00% 否
HY-117690 dBRD9 Degrader 99.89% 否
HY-100352 BI-9564 Inhibitor 98.73% 否
HY-103632 PROTAC BRD9 Degrader-1 Inhibitor / 否
HY-123621 GNE-375 Inhibitor 99.81% 否
HY-110374 NVS-CECR2-1 Inhibitor 99.40% 否
HY-100517 TP-472 Inhibitor 99.52% 否
HY-107477 GSK8573 99.05% 否
HY-101121 NI-42 Inhibitor 99.53% 否
HY-114205A TP-238 hydrochloride Inhibitor ≥99.0% 否
HY-143270 PROTAC BRD9-binding moiety 5 / 否
HY-116227 (2S,3R)-LP99 Inhibitor / 否
HY-149806 Bromodomain IN-2 Inhibitor / 否
HY-114205 TP-238 Inhibitor / 否
HY-163810 BRD9 Degrader-3 Degrader / 否
HY-163809 BRD9 Degrader-2 Degrader / 否
HY-163811 BRD9 Degrader-4 Inhibitor / 否
HY-150797 QA-68 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus BRD9 VGNC VGNC:26561
Felis catus BRD9 VGNC VGNC:60171
Rattus norvegicus BRD9 RGD RGD:1307359
Macaca mulatta BRD9 VGNC VGNC:70386
Mus musculus BRD9 MGD MGI:2145317
Canis familiaris BRD9 VGNC VGNC:49822
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