2. Gene
  3. LGALS8 - galectin 8 Gene

LGALS8 - galectin 8 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：半乳糖凝集素 8

种属: Homo sapiens

同用名: Gal-8; PCTA1; PCTA-1; Po66-CBP

基因 ID: 3964 | 基因类型: protein coding

关于 LGALS8

Cytogenetic location: 1q43 Genomic coordinates (GRCh38): 1:236,518,214-236,552,981 (from NCBI)

This gene has 28 transcripts (splice variants), 279 orthologues and 16 paralogues. Ubiquitous expression in spleen (RPKM 17.5), skin (RPKM 16.3) and 25 other tissues.

功能概要

该基因编码半乳糖凝集素家族的一个成员。半乳糖凝集素是结合β-半乳糖苷的动物凝集素，具有保守的碳水化合物识别结构域。半乳糖凝集素涉及许多基本功能，包括发育、分化、细胞-细胞粘附、细胞-基质相互作用、生长调节、细胞凋亡和 RNA 剪接。该基因在肿瘤组织中广泛表达，似乎与整合素样细胞相互作用有关。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Galectin family. Galectins are beta-galactoside-binding animal lectins with conserved carbohydrate recognition domains. The galectins have been implicated in many essential functions including development, differentiation, cell-cell adhesion, cell-matrix interaction, growth regulation, Apoptosis, and RNA splicing. This gene is widely expressed in tumoral tissues and seems to be involved in integrin-like cell interactions. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

LGALS8 基因产物(4)

mRNA Protein Name
NM_006499.5 NP_006490.3 galectin-8 isoform a
NM_201543.4 NP_963837.1 galectin-8 isoform b
NM_201544.4 NP_963838.1 galectin-8 isoform b
NM_201545.2 NP_963839.1 galectin-8 isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables carbohydrate binding IDA
IDA: 通过直接分析推断
22246324 GOA
enables integrin binding IPI
IPI: 通过物理相互作用推断
19268462 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to virus IMP
IMP: 通过突变表型推断
28077878 GOA
involved in lymphatic endothelial cell migration IDA
IDA: 通过直接分析推断
19268462 GOA
involved in xenophagy IMP
IMP: 通过突变表型推断
22246324 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
19268462 GOA
located in cytosol IDA
IDA: 通过直接分析推断
22246324 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

LGALS8 蛋白结构

Gal-bind_lectin

Gal-bind_lectin: Galactoside-binding lectin (18 - 150)

Gal-bind_lectin

Gal-bind_lectin: Galactoside-binding lectin (186 - 314)

  • 0
  • 100
  • 200
  • 317 a.a.
蛋白主名 其他名称

galectin-8

Po66 carbohydrate binding protein

LGALS8 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
LGALS8 O00214 MID2 Homo sapiens Q9UJV3-2
Y2H Prey Pooling
25416956
种属内
LGALS8 O00214 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
25416956
种属内
LGALS8 O00214 TAX1BP1 Homo sapiens Q86VP1
Anti Tag CoIP
33961781
种属内
LGALS8 O00214 TGIF1 Homo sapiens Q15583
IF
18511908
种属内
LGALS8 O00214 TGIF1 Homo sapiens Q15583
Anti Bait CoIP
18511908
种属内
LGALS8 O00214 TGIF1 Homo sapiens Q15583
Anti Tag CoIP
18511908
种属内
LGALS8 O00214 WFS1 Homo sapiens O76024
Y2H Array
32814053
种属内
LGALS8 O00214 WFS1 Homo sapiens O76024
Validated Y2H
32814053
种属内
LGALS8 O00214 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
种属内
LGALS8 O00214 APEH Homo sapiens P13798
Validated Y2H
25416956
种属内
LGALS8 O00214 APEH Homo sapiens P13798
Y2H Array
31515488
种属内
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Y2H Pooling
16189514
种属内
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Anti Tag CoIP
33961781
种属内
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Y2H Array
31515488
种属内
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Anti Tag CoIP
28514442
种属内
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Validated Y2H
25416956
种属内
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Y2H Prey Pooling
25416956
种属内
LGALS8 O00214 CALCOCO2 Homo sapiens Q13137
Y2H Array
25416956
种属内
LGALS8 O00214 TRIM23 Homo sapiens P36406
Validated Y2H
25416956
种属内
LGALS8 O00214 TRIM23 Homo sapiens P36406
Y2H Prey Pooling
25416956
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 LGALS8 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70190 Galectin-8/LGALS8 Protein, Human O00214-1 (M1-W317) ≥95%
HY-P700081AF Animal-Free Galectin-8/LGALS8 Protein, Human (His) O00214-1 (M2-W317) ≥95%
HY-P700382 Galectin-8/LGALS8 Protein, Human (GST) O00214-1 (M1-W317) ≥95%

关联疾病

疾病名称 别名
Prostatic Hypertrophy

Benign Prostatic Hypertrophy

Prostatic Hyperplasia
Cholesteatoma Of Middle Ear

Cholesteatoma

Epidermosis Of Ear

Epidermosis Of Middle Ear

Middle Ear Cholesteatoma

Cholesteatoma Of Middle Ear And Mastoid

Cholesteatoma Of Middle Ear And/Or Mastoid

Cholesteatoma Of The Middle Ear

Congenital Cholesteatoma

Primary Acquired Cholesteatoma

Secondary Acquired Cholesteatoma

Cholesteatoma Middle Ear

Cholesteatoma, Middle Ear

Cholesterolosis Of Middle Ear

Cholesterosis Of Ear

Cholesterosis Of Middle Ear

Cholesteatoma Nos

Epidermoid Cholesteatoma

Middle Ear Granuloma
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS07609 LGALS8 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus LGALS8 RGD RGD:621272
Macaca mulatta LGALS8 VGNC VGNC:74258
Canis familiaris LGALS8 VGNC VGNC:42650
Bos taurus LGALS8 VGNC VGNC:30855
Mus musculus LGALS8 MGD MGI:1928481
Others LGALS8 NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z