LIMK2 - LIM domain kinase 2 Gene

中文名称：LIM 结构域激酶 2

种属: Homo sapiens

关于 LIMK2

功能概要

大约有 40 种已知的真核 LIM 蛋白，以它们包含的 LIM 结构域命名。 LIM 结构域是高度保守的富含半胱氨酸的结构，包含 2 个锌指。尽管锌指通常通过与 DNA 或 RNA 结合发挥作用，但 LIM 基序可能介导蛋白质-蛋白质相互作用。 LIM 激酶 1 和 LIM 激酶 2 属于一个小亚家族，具有 2 个 N 末端 LIM 基序和一个 C 末端蛋白激酶结构域的独特组合。由该基因编码的蛋白质被 Rho 的下游效应子 ROCK 磷酸化和激活，编码的蛋白质反过来磷酸化 cofilin，抑制其肌动蛋白解聚活性。据认为，该途径有助于 Rho 诱导的肌动蛋白细胞骨架重组。已为该基因发现至少三种编码不同亚型的转录物变体。[RefSeq 提供，2008 年 7 月]

There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin Cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]