1. Gene
  2. TM4SF1 - transmembrane 4 L six family member 1 Gene

TM4SF1 - transmembrane 4 L six family member 1 Gene

中文名称:跨膜 4 L 六个家族成员 1

种属: Homo sapiens

同用名: L6; H-L6; M3S1; TAAL6

基因 ID: 4071 | 基因类型: protein coding

关于 TM4SF1

Cytogenetic location: 3q25.1 Genomic coordinates (GRCh38): 3:149,369,022-149,377,649 (from NCBI)

This gene has 4 transcripts (splice variants), 116 orthologues and 5 paralogues. Broad expression in gall bladder (RPKM 142.0), lung (RPKM 138.0) and 24 other tissues.

功能概要

由该基因编码的蛋白质是跨膜 4 超家族的成员,也称为四跨膜蛋白家族。这些成员中的大多数是细胞表面蛋白,其特征在于存在四个疏水结构域。这些蛋白质介导在细胞发育、活化、生长和运动的调节中起作用的信号转导事件。这种编码的蛋白质是一种细胞表面抗原,在不同的癌中高度表达。[RefSeq 提供,2008 年 7 月]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface antigen and is highly expressed in different carcinomas. [provided by RefSeq, Jul 2008]

TM4SF1 基因产物(2)

mRNA Protein Name
NM_001410837.1 NP_001397766.1 transmembrane 4 L6 family member 1 isoform 2
NM_014220.3 NP_055035.1 transmembrane 4 L6 family member 1 isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11102519 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
7510285 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TM4SF1 蛋白结构

L6_membrane

L6_membrane: L6 membrane protein (1 - 195)

  • 0
  • 100
  • 202 a.a.
蛋白主名 其他名称

transmembrane 4 L6 family member 1

membrane component, chromosome 3, surface marker 1

重组 TM4SF1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P700837 TM4SF1 Protein-VLP, Human (HEK293) P30408 (M1-C202) ≥95%

直系同源

种属 基因名 来源 基因 ID
Bos taurus TM4SF1 VGNC VGNC:35903
Macaca mulatta TM4SF1 VGNC VGNC:110328
Rattus norvegicus TM4SF1 RGD RGD:1309652
Canis familiaris TM4SF1 VGNC VGNC:52907
Mus musculus TM4SF1 MGD MGI:104678
Felis catus TM4SF1 VGNC VGNC:66224
Macaca fascicularis TM4SF1 NCBI NCBI:102142030
Others TM4SF1 NCBI