2. Gene
  3. MEST - mesoderm specific transcript Gene

MEST - mesoderm specific transcript Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：中胚层特异性转录本

种属: Homo sapiens

同用名: PEG1

基因 ID: 4232 | 基因类型: protein coding

关于 MEST

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,486,175-130,506,465 (from NCBI)

This gene has 17 transcripts (splice variants), 242 orthologues and 12 paralogues. Biased expression in placenta (RPKM 292.2), fat (RPKM 48.4) and 6 other tissues.

功能概要

该基因编码 alpha/beta 水解酶超家族的成员。它是印迹的，表现出胎儿组织中父系等位基因的优先表达，以及淋巴细胞中的亚型特异性印迹。该基因印记的丢失与某些类型的癌症有关，可能是由于启动子转换。编码的蛋白质可能在发育中发挥作用。已经为该基因鉴定了编码多种同种型的可变剪接转录物变体。该基因的假基因位于 3 号和 4 号染色体的短臂以及 6 号和 15 号染色体的长臂上。[RefSeq 提供，2011 年 12 月]

This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of Cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]

MEST 基因产物(6)

mRNA Protein Name
NM_001253900.1 NP_001240829.1 mesoderm-specific transcript homolog protein isoform c
NM_001253901.1 NP_001240830.1 mesoderm-specific transcript homolog protein isoform d precursor
NM_001253902.1 NP_001240831.1 mesoderm-specific transcript homolog protein isoform d precursor
NM_002402.4 NP_002393.2 mesoderm-specific transcript homolog protein isoform a
NM_177524.2 NP_803490.1 mesoderm-specific transcript homolog protein isoform b precursor
NM_177525.2 NP_803491.1 mesoderm-specific transcript homolog protein isoform b precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MEST 蛋白结构

Abhydrolase_6

Abhydrolase_6: Alpha/beta hydrolase family (72 - 323)

  • 0
  • 100
  • 200
  • 300
  • 335 a.a.
蛋白主名 其他名称

mesoderm-specific transcript homolog protein

paternally-expressed gene 1 protein

MEST 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MEST Q5EB52 RNF19B Homo sapiens Q6ZMZ0
Y2H Array
32296183
种属内
MEST Q5EB52 RNF19B Homo sapiens Q6ZMZ0
Validated Y2H
32296183
种属内
MEST Q5EB52 RNF19B Homo sapiens Q6ZMZ0
Y2H Prey Pooling
32296183
种属内
MEST Q5EB52 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
种属内
MEST Q5EB52 LIME1 Homo sapiens Q9H400
Validated Y2H
32296183
种属内
MEST Q5EB52 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
种属内
MEST Q5EB52 CIDEB Homo sapiens Q9UHD4
Validated Y2H
32296183
种属内
MEST Q5EB52 CIDEB Homo sapiens Q9UHD4
Y2H Array
32296183
种属内
MEST Q5EB52 CIDEB Homo sapiens Q9UHD4
Y2H Prey Pooling
32296183
种属内
MEST Q5EB52 C6orf47 Homo sapiens O95873
Y2H Prey Pooling
32296183
种属内
MEST Q5EB52 C6orf47 Homo sapiens O95873
Y2H Array
32296183
种属内
MEST Q5EB52 CIAO2A Homo sapiens Q9H5X1
Validated Y2H
32296183
种属内
MEST Q5EB52 GAD2 Homo sapiens Q05329
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Childhood-Onset Schizophrenia

Childhood Schizophrenia

Schizophrenia, Childhood
Adult Cystic Nephroma

Multilocular Cystic Nephroma, Mixed Epithelial Stromal Tumour And Renal Epithelial Stromal Tumour
Mixed Epithelial Stromal Tumour
Kidney Cortex Disease
Transient Neonatal Diabetes Mellitus

Diabetes Mellitus, Transient Neonatal

Tndm

Chromosome 6-Associated Transient Diabetes Mellitus

Dmtn

Diabetes Mellitus, 6q24-Related Transient Neonatal

Tndm1

Neonatal Diabetes Mellitus, Transient

Tndm -[Transient Neonatal Diabetes Mellitus]
Mulchandani-Bhoj-Conlin Syndrome

MBCS

Maternal Uniparental Disomy Of Chromosome 20

Maternal Upd(20)

Upd(20)Mat

Uniparental Disomy, Maternal, Chromosome 20
Hypersensitivity Vasculitis

Cutaneous Small Vessel Vasculitis

Hypersensitivity Angiitis

Cutaneous Leukocytoclastic Vasculitis

Leukocytoclastic Angiitis

Vasculitis, Leukocytoclastic, Cutaneous

Leukocytoclastic Vasculitis

Cutaneous Leukocytoclastic Angiitis

Cutaneous Hypersensitivity Vasculitis

Vasculitis Hypersensitivity

Drug Induced Cutaneous Vasculitis

Allergic Vasculitis
Silver-Russell Syndrome 1

Silver-Russell Syndrome

Russell-Silver Syndrome

Silver-Russell Dwarfism

Rss

SRS1

Srs

Silver Russell Dwarfism

Russell Silver Syndrome

Silver Russell Syndrome
Henoch-Schoenlein Purpura

Henoch-Schonlein Purpura

Iga Vasculitis

Allergic Purpura

Anaphylactoid Purpura

Rheumatoid Purpura

Immunoglobulin A Vasculitis

Vascular Purpura

Purpura Rheumatica

Henoch-Schönlein Purpura

Autoimmune Purpura

Henoch-Schnlein Purpura

Henoch-Sch@Nlein Purpura

Henoch-Scholein Purpura

Purpura, Autoimmune

Henoch Schonlein Purpura

Immunoglobulin-A Vasculitis

Purpura, Schonlein-Henoch

Purpura, Schönlein-Henoch

Hsp -

Schönlein-Henoch Purpura
Hypersensitivity Reaction Type Iii Disease

Immune Complex Diseases

Immune Complex Disease

Type Iii Hypersensitivity Reaction Disease
Rapidly Progressive Glomerulonephritis

Glomerulonephritis Rapidly Progressive

Idiopathic Crescentic Glomerulonephritis
Temple Syndrome

Uniparental Disomy, Maternal, Chromosome 14

Temple Syndrome Due To Paternal 14q32.2 Microdeletion

Paternal Del(14)(Q32.2)

Temple Syndrome Due To Paternal 14q32.2 Hypomethylation

Temple Syndrome Due To Maternal Uniparental Disomy Of Chromosome 14

Upd(14)Mat
Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos
Spastic Paraplegia 17, Autosomal Dominant

Silver Syndrome

SPG17

Silver Spastic Paraplegia Syndrome

Spastic Paraplegia With Amyotrophy Of Hands And Feet

Hereditary Spastic Paraplegia 17

Autosomal Dominant Spastic Paraplegia Type 17

Spastic Paraplegia 17

Spastic Paraplegia-Amyotrophy Of Hands And Feet

Autosomal Dominant Spastic Paraplegia 17

Dhmn5b

Distal Hereditary Motor Neuropathy Type 5b

Paraplegia, Spastic, Autosomal Dominant, Type 17

Russell-Silver Syndrome

Neuronopathy, Distal Hereditary Motor, Type Vb
Iga Glomerulonephritis

Iga Nephropathy

Glomerulonephritis, Iga

Berger'S Iga Or Igg Nephropathy

Focal Glomerulonephritis

Primary Iga Nephropathy

Segmental Glomerulonephritis

Berger Disease

Berger'S Disease

Igan

Nephritis, Iga Type

Nephropathy Iga

Glomerulonephritis Focal

Iga Nephropathy, Susceptibility To

Primary Immunoglobulin A Nephropathy
Kagami-Ogata Syndrome

Paternal Uniparental Disomy Of Chromosome 14

Uniparental Disomy, Paternal, Chromosome 14

Kos

Mca Due To 14q32.2 Maternally Expressed Gene Defect

Paternal Uniparental Disomy 14

Kagami-Ogata Syndrome Due To Maternal 14q32.2 Microdeletion

Maternal Del(14)(Q32.2)

Maternal Monosomy 14q32.2

Kagami-Ogata Syndrome Due To Maternal 14q32.2 Hypermethylation

Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14

Upd(14)Pat
Pseudohypoparathyroidism, Type Ib

Pseudohypoparathyroidism Type 1b

PHP1B

Pseudohypoparathyroidism Ib

Pseudohypoparathyroidism Type Ib

Php Ib

Pseudohypoparathyroidism 1b
Beckwith-Wiedemann Syndrome

Wiedemann-Beckwith Syndrome

BWS

Exomphalos-Macroglossia-Gigantism Syndrome

Emg Syndrome

Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

Emg Abnormality

Wbs

Exomphalos Macroglossia Gigantism Syndrome

Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

Macroglossia Exomphalos Gigantism
Gestational Trophoblastic Neoplasm

Hydatidiform Mole

Molar Pregnancy

Gestational Trophoblastic Neoplasia

Gestational Trophoblastic Tumor

Gtn

Gestational Trophoblastic Disease

Gestational Trophoblastic Neoplasms

Hydatidiform Mole, Recurrent, 1

Hydatidiform Mole Benign

Trophoblastic Disease

Trophoblastic Disease Nos

Trophoblastic Disorder

Vesicular Mole Nos

Vesicular Mole

Hydatidiform Mole Nos
Adult Syndrome

Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome

Acro Dermato Ungual Lacrimal Tooth Syndrome

Pigment Anomaly-Ectrodactyly-Hypodontia Syndrome

Acro-Dermato-Ungual-Lacrimal-Tooth Syndrome

Adult
Prader-Willi Syndrome

Prader-Labhart-Willi Syndrome

PWS

Willi-Prader Syndrome

Prader-Willi Syndrome Due To Translocation

Prader-Willi Syndrome Due To Imprinting Mutation

Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15

Prader Willi Syndrome

Upd(15)Mat
Wilms Tumor 1

Nephroblastoma

Wilms Tumor

WT1

Wilms' Tumor

Bilateral Wilms Tumor

Wilms Tumor, Type 1

Wilms Tumor, Somatic

Adult Nephroblastoma

Wt1 Disorder

Renal Embryonic Tumor

Adult Kidney Wilms Tumor

Childhood Kidney Wilms Tumor

Nonanaplastic Kidney Wilms Tumor
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-14336A SB 271046 Hydrochloride Antagonist 99.93% 否
HY-125928 AA43279 Inhibitor / 否
HY-RS08344 MEST Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MEST VGNC VGNC:43165
Macaca mulatta MEST VGNC VGNC:74707
Rattus norvegicus MEST RGD RGD:1594589
Mus musculus MEST MGD MGI:96968
Bos taurus MEST VGNC VGNC:31393
Felis catus MEST VGNC VGNC:97504
Macaca fascicularis MEST NCBI NCBI:102137842
Others MEST NCBI
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z