2. Gene
  3. NCAM2 - neural cell adhesion molecule 2 Gene

NCAM2 - neural cell adhesion molecule 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：神经细胞粘附分子 2

种属: Homo sapiens

同用名: NCAM21

基因 ID: 4685 | 基因类型: protein coding

关于 NCAM2

Cytogenetic location: 21q21.1 Genomic coordinates (GRCh38): 21:20,998,409-21,543,329 (from NCBI)

This gene has 5 transcripts (splice variants), 217 orthologues and 36 paralogues. Biased expression in brain (RPKM 13.1), adrenal (RPKM 3.2) and 3 other tissues.

功能概要

该基因编码的蛋白质属于免疫球蛋白超家族。它是一种 I 型膜蛋白，可能在初级嗅觉轴突的选择性成束和区域到区域投射中起作用。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]

NCAM2 基因产物(8)

mRNA Protein Name
NM_001352591.2 NP_001339520.1 neural cell adhesion molecule 2 isoform 1 precursor
NM_001352592.2 NP_001339521.1 neural cell adhesion molecule 2 isoform 3
NM_001352593.2 NP_001339522.1 neural cell adhesion molecule 2 isoform 4 precursor
NM_001352594.2 NP_001339523.1 neural cell adhesion molecule 2 isoform 5 precursor
NM_001352595.2 NP_001339524.1 neural cell adhesion molecule 2 isoform 6 precursor
NM_001352596.2 NP_001339525.1 neural cell adhesion molecule 2 isoform 7 precursor
NM_001352597.2 NP_001339526.1 neural cell adhesion molecule 2 isoform 8
NM_004540.5 NP_004531.2 neural cell adhesion molecule 2 isoform 2 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21300289 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCAM2 蛋白结构

I-set

I-set: Immunoglobulin I-set domain (22 - 111)

I-set

I-set: Immunoglobulin I-set domain (117 - 191)

I-set

I-set: Immunoglobulin I-set domain (213 - 298)

I-set

I-set: Immunoglobulin I-set domain (306 - 396)

I-set

I-set: Immunoglobulin I-set domain (414 - 488)

fn3

fn3: Fibronectin type III domain (497 - 581)

fn3

fn3: Fibronectin type III domain (595 - 677)

  • 0
  • 200
  • 400
  • 600
  • 837 a.a.
蛋白主名 其他名称

neural cell adhesion molecule 2

N-CAM-2

NCAM2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NCAM2 O15394 HNRNPC Homo sapiens P07910
Crosslink
30021884
种属内
NCAM2 O15394 NCAM2 Homo sapiens O15394
GMS
21300289
种属内
NCAM2 O15394 SCG3 Homo sapiens Q8WXD2
Y2H Fragment Pooling
35914814
种属内
NCAM2 O15394 SCHIP1 Homo sapiens P0DPB3
Display Tech
20195357
种属内
NCAM2 O15394 CTNND2 Homo sapiens Q9UQB3
Y2H Fragment Pooling
35914814
种属内
NCAM2 O15394 YWHAH Homo sapiens Q04917
Y2H Fragment Pooling
35914814
种属内
NCAM2 O15394 CHD4 Homo sapiens Q14839
Y2H Fragment Pooling
35914814
种属内
NCAM2 O15394 YWHAB Homo sapiens P31946
Y2H Fragment Pooling
35914814
种属内
NCAM2 O15394 NCAM2 Homo sapiens O15394
X-Ray Diffraction
21300289
种属内
NCAM2 O15394 YWHAZ Homo sapiens P63104-1
Y2H Fragment Pooling
35914814
种属内
NCAM2 O15394 YWHAE Homo sapiens P62258
Y2H Fragment Pooling
35914814
种属内
NCAM2 O15394 RALY Homo sapiens Q9UKM9
Crosslink
30021884
种属内
NCAM2 O15394 NCAM2 Homo sapiens O15394
SAXS
21300289
种属内
NCAM2 O15394 YWHAG Homo sapiens P61981
Y2H Fragment Pooling
35914814
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 NCAM2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P76505 OCAM/NCAM2 Protein, Human (HEK293, Fc) O15394-1/NP_004531.2 (L20-N697) ≥95%
HY-P76506 OCAM/NCAM2 Protein, Human (HEK293, His) O15394-1/NP_004531.2 (L20-N697) ≥95%

关联疾病

疾病名称 别名
Lissencephaly 3

LIS3

Lissencephaly Due To Tuba1a Mutation

Lissencephaly Type 3

Lissencephaly, Type 3
Epilepsy, Familial Temporal Lobe, 7

Familial Temporal Lobe Epilepsy 7

ETL7

Epilepsy, Temporal Lobe, Familial, Type 7
Spinocerebellar Ataxia 37

Spinocerebellar Ataxia Type 37

SCA37

Spinocerebellar Ataxia With Altered Vertical Eye Movements
Autism

Autistic Disorder

Autism Susceptibility 1

Childhood Autism

Autistic Disorder Of Childhood Onset

Infantile Autism

Kanner'S Syndrome

Autistic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09064 NCAM2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris NCAM2 VGNC VGNC:43637
Bos taurus NCAM2 VGNC VGNC:31899
Felis catus NCAM2 VGNC VGNC:68422
Rattus norvegicus NCAM2 RGD RGD:1303131
Macaca mulatta NCAM2 VGNC VGNC:75137
Mus musculus NCAM2 MGD MGI:97282
Others NCAM2 NCBI
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