NCL - nucleolin Gene

中文名称：核仁素

种属: Homo sapiens

同用名: C23; Nsr1

基因 ID: 4691 | 基因类型: protein coding

关于 NCL

Cytogenetic location: 2q37.1 Genomic coordinates (GRCh38): 2:231,453,531-231,464,484 (from NCBI)

This gene has 24 transcripts (splice variants), 125 orthologues and 36 paralogues. Ubiquitous expression in lymph node (RPKM 147.8), appendix (RPKM 146.7) and 25 other tissues.

功能概要

核仁素 (NCL) 是一种真核生物核仁磷蛋白，参与核糖体的合成和成熟。它主要位于核仁的致密纤维状区域。人类 NCL 基因由 14 个外显子和 13 个内含子组成，跨度约为 11kb。 NCL 基因的内含子 11 编码一种称为 U20 的小核仁 RNA。[RefSeq 提供，2008 年 7 月]

Nucleolin (NCL), a eukaryotic nucleolar phosphoprotein, is involved in the synthesis and maturation of ribosomes. It is located mainly in dense fibrillar regions of the nucleolus. Human NCL gene consists of 14 exons with 13 introns and spans approximately 11kb. The intron 11 of the NCL gene encodes a small nucleolar RNA, termed U20. [provided by RefSeq, Jul 2008]

NCL 基因产物(1)

mRNA	Protein	Name
NM_005381.3	NP_005372.2	nucleolin

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables DNA topoisomerase binding	IPI IPI: 通过物理相互作用推断	8567649	GOA
enables RNA binding	IDA IDA: 通过直接分析推断	8321232	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	21575138	GOA
enables mRNA 5'-UTR binding	IDA IDA: 通过直接分析推断	16213212	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12147681	GOA
enables telomeric DNA binding	IDA IDA: 通过直接分析推断	8321232	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in angiogenesis	IDA IDA: 通过直接分析推断	16403913	GOA
involved in negative regulation of translation	IMP IMP: 通过突变表型推断	16213212	GOA
involved in positive regulation of transcription of nucleolar large rRNA by RNA polymerase I	IMP IMP: 通过突变表型推断	24071584	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell cortex	IDA IDA: 通过直接分析推断	16403913	GOA
located in cytoplasmic ribonucleoprotein granule	IDA IDA: 通过直接分析推断	15121898	GOA
located in nucleolus	IDA IDA: 通过直接分析推断	12944467	GOA
located in nucleoplasm	IDA IDA: 通过直接分析推断	23353999	GOA
located in nucleus	IDA IDA: 通过直接分析推断	15121898	GOA
part of ribonucleoprotein complex	IDA IDA: 通过直接分析推断	17289661	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NCL 蛋白结构

RRM_1

0
200
400
600
710 a.a.

蛋白主名

其他名称

nucleolin

重组 NCL 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71760	NCL Protein, Human (P.pastoris, His)	P19338 (V2-S482)	≥95%

关联疾病

疾病名称

别名

Cockayne Syndrome

Cockayne'S Syndrome	Dwarfism-Retinal Atrophy-Deafness Syndrome
Neill-Dingwall Syndrome	Progeria-Like Syndrome
Progeroid Nanism	Cs

Spinal Muscular Atrophy

Sma	5q Sma
Proximal Sma	Sma-Associated Sma
Spinal Amyotrophies	Spinal Amyotrophy
Spinal Muscle Degeneration	Spinal Muscle Wasting
Muscular Atrophy Spinal	Atrophy, Muscular, Spinal
Hereditary Motor Neuronopathy	Progressive Muscular Atrophy
Sma - [Spinal Muscular Atrophy]

Autoimmune Disease

Autoimmune Diseases	Autoimmune Hypersensitivity Disease
Hypersensitivity Reaction Type Ii Disease	Type Ii Hypersensitivity Reaction Disease

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Systemic Lupus Erythematosus

Lupus Nephritis	SLE
Disseminated Lupus Erythematosus	Systemic Lupus Erythematosus, Susceptibility To
Lupus Erythematosus, Systemic	Lupus Nephritis, Susceptibility To
Libman-Sacks Disease	Systemic Lupus Erythematosus Susceptibility To
Sle - Lupus Erythematosus, Systemic	Le Syndrome
Lupus	Lupus Erythematosus Systemic
Lupus Erythematosus, Systemic, Susceptibility To	Lupus Vulgaris
Lupus Erythematosus, Discoid	Lupus Erythematosus
Systemic Lupus Erythematosus Nos	Sle - [Systemic Lupus Erythematosus]

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia	Aase Syndrome
Erythrogenesis Imperfecta	Anemia, Diamond-Blackfan
Congenital Hypoplastic Anemia	Aase-Smith Ii Syndrome
Bds	Blackfan-Diamond Anemia
Congenital Prca	Congenital Hypoplastic Anemia, Blackfan-Diamond Type
Dba	Blackfan - Diamond Syndrome
Chronic Constitutional Pure Red Cell Anaemia	Anemia Diamond Blackfan Type
Anemia Congenital Erythroid Hypoplastic	Aregenerative Anemia Chronic Congenital
Blackfan Diamond Syndrome	Red Cell Aplasia, Pure Hereditary
Aase-Smith Syndrome Ii	Bda
Blackfan Diamond Anemia	Blackfan-Diamond Disease
Blackfan-Diamond Syndrome	Chronic Congenital Agenerative Anemia
Congenital Erythroid Hypoplastic Anemia	Congenital Hypoplastic Anemia Of Blackfan And Diamond
Congenital Pure Red Cell Anemia	Hypoplastic Congenital Anemia
Inherited Erythroblastopenia	Pure Hereditary Red Cell Aplasia
Anemia, Hypoplastic, Congenital	Anemia Hypoplastic Congenital
Fanconi Anemia	Constitutional Aplastic Anemia
Diamond-Blackfan Anemia 1	Aase Smith Syndrome 2
Congenital Red Cell Aplasia	Red Cell Aplasia Of Infants
Pure Red Cell Aplasia Of Infants	Congenital Red Cell Aplastic Anaemia
Congenital Pure Red Cell Anaemia	Congenital Erythroid Hypoplasia
Pearson Marrow-Pancreas Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-117074	BMS-247243		/	否
HY-12645	NCL1	Inhibitor	/	否
HY-RS09086	NCL Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-P5551	TLN-58	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	NCL	VGNC	VGNC:68430
Canis familiaris	NCL	VGNC	VGNC:43657
Mus musculus	NCL	MGD	MGI:97286
Macaca mulatta	NCL	VGNC	VGNC:75144
Rattus norvegicus	NCL	RGD	RGD:3153
Others	NCL	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

NCL - nucleolin Gene

关于 NCL

功能概要

NCL 基因产物(1)

NCL 蛋白结构

重组 NCL 蛋白

关联疾病

直系同源

热门区域

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NCL - nucleolin Gene

关于 NCL

功能概要

NCL 基因产物(1)

NCL 蛋白结构

重组 NCL 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z