2. Gene
  3. NFE2 - nuclear factor, erythroid 2 Gene

NFE2 - nuclear factor, erythroid 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核因子，红细胞 2

种属: Homo sapiens

同用名: p45; NF-E2

基因 ID: 4778 | 基因类型: protein coding

关于 NFE2

Cytogenetic location: 12q13.13 Genomic coordinates (GRCh38): 12:54,292,111-54,301,015 (from NCBI)

This gene has 5 transcripts (splice variants), 188 orthologues and 3 paralogues. Biased expression in bone marrow (RPKM 31.8), spleen (RPKM 3.5) and 3 other tissues.

功能概要

启用多项功能，包括 WW 域绑定活动；相同的蛋白质结合活性；和蛋白质 N 末端结合活性。有助于顺式调节区序列特异性 DNA 结合活性。预计参与 RNA 聚合酶 II 的转录调控。预计在几个过程的上游或内部起作用，包括迷宫层血管发育；骨矿化的负调节；质膜融合对合胞体形成的负调控。蛋白质-DNA 复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including WW domain binding activity; identical protein binding activity; and protein N-terminus binding activity. Contributes to cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of bone mineralization; and negative regulation of syncytium formation by plasma membrane fusion. Part of protein-DNA complex. [provided by Alliance of Genome Resources, Apr 2022]

NFE2 基因产物(6)

mRNA Protein Name
NM_001136023.3 NP_001129495.1 transcription factor NF-E2 45 kDa subunit isoform 1
NM_001261461.2 NP_001248390.1 transcription factor NF-E2 45 kDa subunit isoform 1
NM_001400365.1 NP_001387294.1 transcription factor NF-E2 45 kDa subunit isoform 1
NM_001400372.1 NP_001387301.1 transcription factor NF-E2 45 kDa subunit isoform 2
NM_001400373.1 NP_001387302.1 transcription factor NF-E2 45 kDa subunit isoform 2
NM_006163.3 NP_006154.1 transcription factor NF-E2 45 kDa subunit isoform 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
12609092 GOA
enables WW domain binding IDA
IDA: 通过直接分析推断
9305852 GOA
enables WW domain binding IPI
IPI: 通过物理相互作用推断
9305852 GOA
contributes to cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16263792 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
20102225 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
11863372 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of RNA polymerase II transcription regulator complex IPI
IPI: 通过物理相互作用推断
20102225 GOA
part of protein-DNA complex IDA
IDA: 通过直接分析推断
12609092 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NFE2 蛋白结构

bZIP_Maf

bZIP_Maf: bZIP Maf transcription factor (239 - 329)

  • 0
  • 100
  • 200
  • 300
  • 373 a.a.
蛋白主名 其他名称

transcription factor NF-E2 45 kDa subunit

leucine zipper protein NF-E2

NFE2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NFE2 Q16621 NFE2L3 Homo sapiens Q9Y4A8
Peptide Array
20102225
种属内
NFE2 Q16621 NFE2L3 Homo sapiens Q9Y4A8
FRET
23661758
种属内
NFE2 Q16621 GLE1 Homo sapiens Q53GS7
Validated Y2H
32814053
种属内
NFE2 Q16621 GLE1 Homo sapiens Q53GS7
Y2H Array
32814053
种属内
NFE2 Q16621 GLE1 Homo sapiens Q53GS7
Y2H Pooling
32814053
种属内
NFE2 Q16621 q9y649_human Homo sapiens Q9Y649
Validated Y2H
32814053
种属内
NFE2 Q16621 q9y649_human Homo sapiens Q9Y649
Y2H Array
32814053
种属内
NFE2 Q16621 q9y649_human Homo sapiens Q9Y649
Y2H Pooling
32814053
种属内
NFE2 Q16621 BTRC Homo sapiens Q9Y297
Validated Y2H
25416956
种属内
NFE2 Q16621 BTRC Homo sapiens Q9Y297
Y2H Prey Pooling
25416956
种属内
NFE2 Q16621 FGFR3 Homo sapiens P22607
Validated Y2H
32814053
种属内
NFE2 Q16621 FGFR3 Homo sapiens P22607
Y2H Array
32814053
种属内
NFE2 Q16621 FGFR3 Homo sapiens P22607
Y2H Pooling
32814053
种属内
NFE2 Q16621 GSN Homo sapiens P06396
Validated Y2H
32814053
种属内
NFE2 Q16621 GSN Homo sapiens P06396
Y2H Array
32814053
种属内
NFE2 Q16621 GSN Homo sapiens P06396
Y2H Pooling
32814053
种属内
NFE2 Q16621 SPRED1 Homo sapiens Q7Z699
Y2H Pooling
32814053
种属内
NFE2 Q16621 SPRED1 Homo sapiens Q7Z699
Validated Y2H
32814053
种属内
NFE2 Q16621 SPRED1 Homo sapiens Q7Z699
Y2H Array
32814053
种属内
NFE2 Q16621 NFE2 Homo sapiens Q16621
Peptide Array
20102225
种属内
NFE2 Q16621 NFE2 Homo sapiens Q16621
FRET
23661758
种属间
NFE2 Q16621 MDV005 Gallid herpesvirus 2 Q9DGW5
Peptide Array
20102225
种属间: 跨种属相互作用 种属内: 同种属相互作用

NFE2 抗体

目录号 产品名 应用 反应物种
HY-P81464 NFE2 Antibody (YA1209) IHC-P Human

关联疾病

疾病名称 别名
Erythroleukemia
Polycythemia

Erythrocythemia

Polycythemia Vera

Polycythaemia Due To High Altitude
Polycythemia Vera

PV

Polycythemia Rubra Vera

Prv

Osler-Vaquez Disease

Chronic Erythremia

Polycythaemia Rubra Vera

Primary Polycythemia

Vaquez Disease

Polycythemia Vera, Somatic

Osler-Vaquez Syndrome

Proliferative Polycythaemia

Polycythemia Ruba Vera

Acquired Primary Erythrocytosis

Heilmeyer-Schoner Disease

Vaquez Osler Disease

Primary Polycythaemia
Myelofibrosis

Primary Myelofibrosis

Agnogenic Myeloid Metaplasia

Idiopathic Myelofibrosis

Myeloid Metaplasia

Myelofibrosis With Myeloid Metaplasia

Osteomyelofibrosis

Megakaryocytic Myelosclerosis

Myelosclerosis

Chronic Idiopathic Myelofibrosis

Myelofibrosis, Idiopathic

Myelofibrosis With Myeloid Metaplasia, Somatic

Myelofibrosis, Somatic

Aleukemic Myelosis

Bone Marrow Fibrosis

MYELOF

MMM

Agnogenic Myeloid Metaplasia With Myelofibrosis

Ammm

Myelosclerosis With Myeloid Metaplasia

Myelofibrosis Nos
Thrombocytopenia

Low Platelet Count

Low Platelets

Decreased Platelets

Platelet Dysfunction Nos
Acute Erythroid Leukemia

Acute Erythroleukemia

Di Guglielmo'S Syndrome

Aml M6

Acute Myeloid Leukemia Fab-M6

Acute Myeloid Leukemia M6

Erythroleukemia

Aml-M6

Acute Erythroleukemia M6a Subtype

Acute Erythroleukemia M6b Subtype

Di Guglielmo Syndrome

Acute Myeloid Leukemia, M6 Type

Acute Erythroblastic Leukemia

Acute Erythroleukemia - M6a Subtype

Acute Erythroleukemia - M6b Subtype

Acute Erythraemia And Erythroleukaemia

Acute Erythroid Leukaemia Without Mention Of Remission

Erythraemia

Erythraemic Myelosis

Erythroleukaemia

Acute Erythraemic Myelosis

Acute Erythraemia
Hemoglobin H Disease

HBH

Hemoglobin H Disease, Nondeletional

Hemoglobin H Disease, Deletional

Alpha-Thalassemia Intermedia

Haemoglobin H Disease

Alpha-Thalassemia, Hemoglobin H Type

Hemoglobin H Disease, Deletional And Nondeletional

Alpha Thalassemia, Haemoglobin H Type

Alpha Thalassemia, Hemoglobin H Type

Haemoglobin H Disease, Deletional

Hbh Disease

Alpha-Thalassemia Hemoglobin H Type

Hemoglobin H Disease Deletional

Hemoglobin H Disease Non-Deletional

Alpha-Thalassemia

Alpha - /- - Or Mutational Forms Of Alpha-Thalassaemia

Alpha Thalassaemia Intermedia
Essential Thrombocythemia

Essential Thrombocytosis

Familial Thrombocytosis

Hemorrhagic Thrombocythemia

Hereditary Thrombocythemia

Primary Thrombocytosis

Idiopathic Thrombocythemia

Primary Thrombocythemia

Thrombocythemia, Essential

Essential Thrombocythaemia

Et

Familial Thrombocythemia

Thrombocythemia Essential
Deficiency Anemia

Anemia

Deficiency Anemias

Anaemia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (9)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-12213 CDDO-EA Activator 99.71% 否
HY-145390 Nrf2 activator-1 Activator 95.74% 否
HY-RS09245 NFE2L2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-N6802 Tigloylgomisin H Inducer / 否
HY-RS09243 NFE2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09244 NFE2L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09246 Nfe2l2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09247 Nfe2l2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09248 NFE2L3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus NFE2 VGNC VGNC:68473
Macaca mulatta NFE2 VGNC VGNC:75330
Canis familiaris NFE2 VGNC VGNC:43771
Mus musculus NFE2 MGD MGI:97308
Bos taurus NFE2 VGNC VGNC:32034
Rattus norvegicus NFE2 RGD RGD:1306888
Others NFE2 NCBI
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