2. Gene
  3. Scn3a - sodium voltage-gated channel alpha subunit 3 Gene

Scn3a - sodium voltage-gated channel alpha subunit 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：钠电压门控通道 α 亚基 3

种属: Rattus norvegicus

同用名: SCIII; Scn2a; Nav1.3

基因 ID: 497770 | 基因类型: protein coding

关于 Scn3a

Primary_assembly 3: 50,148,139-50,258,119 reverse strand.mRatBN7.2:CM026976.1

This gene has 4 transcripts (splice variants), 130 orthologues, 26 paralogues and is associated with 24 phenotypes. Biased expression in Brain (RPKM 164.9), Muscle (RPKM 25.) and 5 other tissues.

功能概要

该基因编码的蛋白可启动钙调蛋白结合活动；钠离子结合活性；和电压门控钠通道活性。参与多个过程，包括细胞对抗生素的反应；神经元动作电位；和对拟除虫菊酯的反应。位于轴突和神经细胞体。电压门控钠通道复合体的一部分。该基因的人类直系同源基因与发育和癫痫性脑病 62 以及局灶性癫痫有关。与人类 SCN3A（钠电压门控通道 α 亚基 3）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Calmodulin binding activity; sodium ion binding activity; and voltage-gated Sodium Channel activity. Involved in several processes, including cellular response to antibiotic; neuronal action potential; and response to pyrethroid. Located in axon and neuronal cell body. Part of voltage-gated Sodium Channel complex. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 62 and focal epilepsy. Orthologous to human SCN3A (sodium voltage-gated channel alpha subunit 3). [provided by Alliance of Genome Resources, Apr 2022]

Scn3a 基因产物(1)

mRNA Protein Name
NM_013119.2 NP_037251.2 sodium channel protein type 3 subunit alpha
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calmodulin binding IDA
IDA: 通过直接分析推断
16912065 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
15317864 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to antibiotic IDA
IDA: 通过直接分析推断
18839021 RGD
involved in nervous system development IEP
IEP: 通过表达模式推断
19269275 RGD
involved in response to pyrethroid IDA
IDA: 通过直接分析推断
19026681 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
16966585 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
16966585 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Scn3a 蛋白结构

Ion_trans

Ion_trans: pfam00520 (126 - 433)

Na_trans_cytopl

Na_trans_cytopl: pfam11933 (557 - 692)

Ion_trans

Ion_trans: pfam00520 (741 - 954)

Na_trans_assoc

Na_trans_assoc: pfam06512 (980 - 1182)

Ion_trans

Ion_trans: pfam00520 (1187 - 1459)

Na_channel_gate

Na_channel_gate: cd13433 (1451 - 1503)

Ion_trans

Ion_trans: pfam00520 (1507 - 1763)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 1983 a.a.
蛋白主名 其他名称

sodium channel protein type 3 subunit alpha

rCG26412-like

sodium channel protein type 3 subunit alpha-like

sodium channel protein type III subunit alpha

sodium channel protein, brain III subunit alpha

sodium channel, voltage-gated, type 3, alpha subunit

sodium channel, voltage-gated, type III, alpha subunit

voltage-gated sodium channel subtype III

voltage-gated sodium channel subunit alpha Nav1.3

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12533 SCN3A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12534 Scn3a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS12535 Scn3a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Scn3a NCBI NCBI:6328
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