2. Gene
  3. Rad51 - RAD51 recombinase Gene

Rad51 - RAD51 recombinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：RAD51 重组酶

种属: Rattus norvegicus

同用名: RGD1563603

基因 ID: 499870 | 基因类型: protein coding

关于 Rad51

Primary_assembly 3: 106,100,381-106,125,035 forward strand.mRatBN7.2:CM026976.1

This gene has 3 transcripts (splice variants), 220 orthologues, 5 paralogues and is associated with 20 phenotypes. Biased expression in Thymus (RPKM 112.8), Spleen (RPKM 6.) and 9 other tissues.

功能概要

预计该基因编码的蛋白可启动多种功能，包括 ATP 绑定活动； DNA结合活性；和催化活性，作用于 DNA。参与多个过程，包括细胞对顺铂的反应；细胞对伽马辐射的反应；和对 X 射线的反应。位于核内。用于研究心肌病和高血压。胰腺癌的生物标志物。该基因的人类直系同源物涉及范可尼贫血互补组 R；乳腺癌;先天性镜像运动障碍；和卵巢癌。与人 RAD51 同源（RAD51 重组酶）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including ATP binding activity; DNA binding activity; and catalytic activity, acting on DNA. Involved in several processes, including cellular response to cisplatin; cellular response to gamma radiation; and response to X-ray. Located in nucleus. Used to study cardiomyopathy and hypertension. Biomarker of pancreatic Cancer. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian Cancer. Orthologous to human RAD51 (RAD51 recombinase). [provided by Alliance of Genome Resources, Apr 2022]

Rad51 基因产物(1)

mRNA Protein Name
NM_001109204.1 NP_001102674.1 DNA repair protein RAD51 homolog 1
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to cisplatin IEP
IEP: 通过表达模式推断
14755242 RGD
involved in cellular response to gamma radiation IEP
IEP: 通过表达模式推断
9885240 RGD
involved in double-strand break repair via homologous recombination IEP
IEP: 通过表达模式推断
14755242 RGD
involved in meiosis I IEP
IEP: 通过表达模式推断
25142975 RGD
involved in response to X-ray IEP
IEP: 通过表达模式推断
17148264 RGD
involved in response to glucoside IEP
IEP: 通过表达模式推断
9885240 RGD
involved in response to organic cyclic compound IEP
IEP: 通过表达模式推断
23969067 RGD
involved in response to toxic substance IEP
IEP: 通过表达模式推断
24243707 RGD
involved in response to xenobiotic stimulus IEP
IEP: 通过表达模式推断
11754170 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Rad51 蛋白结构

recomb_RAD51

recomb_RAD51: TIGR02239 (24 - 338)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
蛋白主名 其他名称

DNA repair protein RAD51 homolog 1

RAD51 homolog

相关产品

Clinical Phase
生物活性分子 (3)
目录号 产品名 作用方式
纯度 Phase
HY-19793 RS-1 Activator 98.95% Phase 2
HY-10206 Amuvatinib Inhibitor 99.47% Phase 2
HY-10206A Amuvatinib hydrochloride Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (23)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-D0086 DIDS sodium salt Inhibitor 99.13% 否
HY-101462 RAD51 Inhibitor B02 Inhibitor 99.91% 否
HY-15317 RI-1 Inhibitor 99.83% 否
HY-103710 IBR2 Inhibitor 98.34% 否
HY-150147 CAM833 Inhibitor 99.79% 否
HY-126020 Bractoppin Inhibitor 99.70% 否
HY-N3980 Guaiol 99.67% 否
HY-122705 RAD51-IN-1 Inhibitor 99.89% 否
HY-16904 RI-2 Inhibitor 99.90% 否
HY-111887 Emzadirib Inhibitor 99.63% 否
HY-148183 Homologous recombination-IN-1 Inhibitor 99.65% 否
HY-126972A RI(dl)-2 TFA Inhibitor 98.02% 否
HY-136604 RAD51-IN-3 Inhibitor 99.24% 否
HY-143736 RAD51-IN-5 Inhibitor 98.87% 否
HY-143737 RAD51-IN-6 Inhibitor / 否
HY-143741 RAD51-IN-7 Inhibitor / 否
HY-143735 RAD51-IN-4 Inhibitor / 否
HY-169213 LN-439A Inhibitor / 否
HY-103710A (R)-IBR2 Control / 否
HY-121693 DIDS Inhibitor / 否
HY-126972 RI(dl)-2 Inhibitor / 否
HY-150958 RAD51-IN-8 / 否
HY-P10516 BRC4 peptide / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rad51 NCBI NCBI:5888
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