2. Gene
  3. ITSN2 - intersectin 2 Gene

ITSN2 - intersectin 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：相交 2

种属: Homo sapiens

同用名: SWA; SWAP; SH3D1B; SH3P18; PRO2015

基因 ID: 50618 | 基因类型: protein coding

关于 ITSN2

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,202,864-24,361,368 (from NCBI)

This gene has 12 transcripts (splice variants), 293 orthologues and 10 paralogues. Ubiquitous expression in thyroid (RPKM 16.9), lymph node (RPKM 13.9) and 25 other tissues.

功能概要

该基因编码含有 SH3 结构域的细胞质蛋白。该蛋白质是参与网格蛋白介导的内吞作用的蛋白质家族的成员。 Intersectin 2 被认为可以调节网格蛋白涂层囊泡的形成，也可能在诱导 T 细胞抗原受体 (TCR) 内吞作用中发挥作用。[RefSeq 提供，2017 年 1 月]

This gene encodes a cytoplasmic protein which contains SH3 domains. This protein is a member of a family of proteins involved in clathrin-mediated endocytosis. Intersectin 2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. [provided by RefSeq, Jan 2017]

ITSN2 基因产物(9)

mRNA Protein Name
NM_001348181.2 NP_001335110.1 intersectin-2 isoform 4
NM_001348182.2 NP_001335111.1 intersectin-2 isoform 5
NM_001348183.2 NP_001335112.1 intersectin-2 isoform 6
NM_001348184.2 NP_001335113.1 intersectin-2 isoform 7
NM_001348185.2 NP_001335114.1 intersectin-2 isoform 8
NM_001348186.2 NP_001335115.1 intersectin-2 isoform 9
NM_006277.3 NP_006268.2 intersectin-2 isoform 1
NM_019595.4 NP_062541.3 intersectin-2 isoform 3
NM_147152.3 NP_671494.2 intersectin-2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
17696407 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in positive regulation of dendrite extension IDA
IDA: 通过直接分析推断
23999003 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in centrosome IDA
IDA: 通过直接分析推断
20479469 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ITSN2 蛋白结构

EF-hand_4

EF-hand_4: Cytoskeletal-regulatory complex EF hand (19 - 91)

EF-hand_4

EF-hand_4: Cytoskeletal-regulatory complex EF hand (247 - 330)

SH3_9

SH3_9: Variant SH3 domain (764 - 814)

SH3_2

SH3_2: Variant SH3 domain (903 - 953)

SH3_1

SH3_1: SH3 domain (987 - 1031)

SH3_1

SH3_1: SH3 domain (1063 - 1109)

SH3_9

SH3_9: Variant SH3 domain (1134 - 1182)

RhoGEF

RhoGEF: RhoGEF domain (1214 - 1394)

C2

C2: C2 domain (1571 - 1651)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1500
  • 1697 a.a.
蛋白主名 其他名称

intersectin-2

SH3 domain-containing protein 1B

ITSN2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
Intra ITSN2 Q9NZM3 EPS15L1 Homo sapiens Q9UBC2
Anti Tag CoIP
35271311
Intra ITSN2 Q9NZM3 EGFR Homo sapiens P00533
Ub Reconstruction
24658140
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Nephrotic Syndrome, Type 22

NPHS22

Nephrotic Syndrome Type 22

Nephrotic Syndrome 22
Chromosome 17q12 Deletion Syndrome

17q12 Microdeletion Syndrome

Del(17)(Q12)

Monosomy 17q12
Nephrotic Syndrome, Type 21

NPHS21

Nephrotic Syndrome Type 21

Nephrotic Syndrome 21
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06998 ITSN2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus ITSN2 VGNC VGNC:67873
Bos taurus ITSN2 VGNC VGNC:30353
Macaca mulatta ITSN2 VGNC VGNC:73807
Rattus norvegicus ITSN2 RGD RGD:1590890
Mus musculus ITSN2 MGD MGI:1338049
Canis familiaris ITSN2 VGNC VGNC:42162
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