2. Gene
  3. ANAPC11 - anaphase promoting complex subunit 11 Gene

ANAPC11 - anaphase promoting complex subunit 11 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：后期促进复合亚基 11

种属: Homo sapiens

同用名: APC11; Apc11p; HSPC214

基因 ID: 51529 | 基因类型: protein coding

关于 ANAPC11

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,890,790-81,900,533 (from NCBI)

This gene has 23 transcripts (splice variants), 166 orthologues and 2 paralogues. Ubiquitous expression in testis (RPKM 15.1), heart (RPKM 13.6) and 25 other tissues.

功能概要

启用 cullin 家族蛋白结合活性和泛素-泛素连接酶活性。有助于泛素蛋白转移酶活性。参与蛋白质 K11 连接的泛素化。位于核仁和核质中。后期促进复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables cullin family protein binding activity and ubiquitin-ubiquitin Ligase activity. Contributes to ubiquitin-protein transferase activity. Involved in protein K11-linked ubiquitination. Located in nucleolus and nucleoplasm. Part of anaphase-promoting complex. [provided by Alliance of Genome Resources, Apr 2022]

ANAPC11 基因产物(12)

mRNA Protein Name
NM_001002244.2 NP_001002244.1 anaphase-promoting complex subunit 11 isoform 1
NM_001002245.2 NP_001002245.1 anaphase-promoting complex subunit 11 isoform 2
NM_001002246.2 NP_001002246.1 anaphase-promoting complex subunit 11 isoform 2
NM_001002247.2 NP_001002247.1 anaphase-promoting complex subunit 11 isoform 2
NM_001002248.3 NP_001002248.1 anaphase-promoting complex subunit 11 isoform 2
NM_001002249.2 NP_001002249.1 anaphase-promoting complex subunit 11 isoform 2
NM_001289414.1 NP_001276343.1 anaphase-promoting complex subunit 11 isoform 2
NM_001289415.1 NP_001276344.1 anaphase-promoting complex subunit 11 isoform 2
NM_001289416.1 NP_001276345.1 anaphase-promoting complex subunit 11 isoform 2
NM_001289417.1 NP_001276346.1 anaphase-promoting complex subunit 11 isoform 2
NM_001289420.1 NP_001276349.1 anaphase-promoting complex subunit 11 isoform 4
NM_016476.11 NP_057560.8 anaphase-promoting complex subunit 11 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cullin family protein binding IDA
IDA: 通过直接分析推断
10230407 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
enables ubiquitin protein ligase activity IDA
IDA: 通过直接分析推断
10230407 GOA
contributes to ubiquitin-protein transferase activity IDA
IDA: 通过直接分析推断
11739784 GOA
enables ubiquitin-ubiquitin ligase activity IDA
IDA: 通过直接分析推断
10230407 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in anaphase-promoting complex-dependent catabolic process IDA
IDA: 通过直接分析推断
29033132 GOA
involved in positive regulation of mitotic metaphase/anaphase transition IDA
IDA: 通过直接分析推断
11739784 GOA
involved in protein K11-linked ubiquitination IDA
IDA: 通过直接分析推断
18485873 GOA
involved in protein K48-linked ubiquitination IDA
IDA: 通过直接分析推断
29033132 GOA
involved in protein branched polyubiquitination IDA
IDA: 通过直接分析推断
29033132 GOA
involved in protein ubiquitination IDA
IDA: 通过直接分析推断
11739784 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of anaphase-promoting complex IDA
IDA: 通过直接分析推断
11739784 GOA
part of anaphase-promoting complex IPI
IPI: 通过物理相互作用推断
27120157 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ANAPC11 蛋白结构

zf-ANAPC11

zf-ANAPC11: Anaphase-promoting complex subunit 11 RING-H2 finger (1 - 84)

  • 0
  • 84 a.a.
蛋白主名 其他名称

anaphase-promoting complex subunit 11

APC11 anaphase promoting complex subunit 11 homolog

ANAPC11 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
ANAPC11 Q9NYG5 PEX1 Homo sapiens O43933
Validated Y2H
32814053
种属内
ANAPC11 Q9NYG5 PEX1 Homo sapiens O43933
Y2H Array
32814053
种属内
ANAPC11 Q9NYG5 PEX1 Homo sapiens O43933
Y2H Pooling
32814053
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Milker'S Nodule

Poxviridae Infections

Milker Nodule

Milkers' Node

Paravaccinia

Pseudocowpox

Milker'S Nodes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00679 ANAPC11 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris ANAPC11 VGNC VGNC:51919
Rattus norvegicus ANAPC11 RGD RGD:1561880
Bos taurus ANAPC11 VGNC VGNC:55771
Macaca mulatta ANAPC11 VGNC VGNC:99115
Mus musculus ANAPC11 MGD MGI:1913406
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