2. Gene
  3. SIRT7 - sirtuin 7 Gene

SIRT7 - sirtuin 7 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：沉默信息调节因子 2 相关酶类 7

种属: Homo sapiens

同用名: SIR2L7

基因 ID: 51547 | 基因类型: protein coding

关于 SIRT7

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,911,939-81,918,176 (from NCBI)

This gene has 21 transcripts (splice variants), 189 orthologues and 6 paralogues. Ubiquitous expression in stomach (RPKM 8.5), bone marrow (RPKM 8.5) and 25 other tissues.

功能概要

该基因编码 沉默信息调节因子 2 相关酶类 蛋白家族的成员，与酵母 Sir2 蛋白同源。 沉默信息调节因子 2 相关酶类 家族的成员以 沉默信息调节因子 2 相关酶类 核心域为特征，分为四类。人类 沉默信息调节因子 2 相关酶类 s 的功能尚未确定；然而，已知酵母 沉默信息调节因子 2 相关酶类 蛋白可调节表观遗传基因沉默并抑制 rDNA 的重组。研究表明，人类 沉默信息调节因子 2 相关酶类 s 可能作为具有单 ADP 核糖基转移酶活性的细胞内调节蛋白发挥作用。由该基因编码的蛋白质属于 沉默信息调节因子 2 相关酶类 家族的 IV 类。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the Sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the Sirtuin family are characterized by a Sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast Sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the Sirtuin family. [provided by RefSeq, Jul 2008]

SIRT7 基因产物(6)

mRNA Protein Name
XM_011523580.2 XP_011521882.1 NAD-dependent protein deacetylase sirtuin-7 isoform X1
XM_047436231.1 XP_047292187.1 NAD-dependent protein deacetylase sirtuin-7 isoform X5
XM_047436229.1 XP_047292185.1 NAD-dependent protein deacetylase sirtuin-7 isoform X3
XM_047436228.1 XP_047292184.1 NAD-dependent protein deacetylase sirtuin-7 isoform X2
XM_047436230.1 XP_047292186.1 NAD-dependent protein deacetylase sirtuin-7 isoform X4
NM_016538.3 NP_057622.1 NAD-dependent protein deacetylase sirtuin-7
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables NAD-dependent histone H3K18 deacetylase activity IDA
IDA: 通过直接分析推断
22722849 GOA
enables NAD-dependent histone H3K18 deacetylase activity IMP
IMP: 通过突变表型推断
28655758 GOA
enables NAD-dependent protein lysine deacetylase activity IDA
IDA: 通过直接分析推断
24207024 GOA
enables chromatin binding IDA
IDA: 通过直接分析推断
22722849 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19174463 GOA
enables protein methyltransferase activity IDA
IDA: 通过直接分析推断
24207024 GOA
enables protein-glutaryllysine deglutarylase activity IDA
IDA: 通过直接分析推断
31542297 GOA
enables protein-succinyllysine desuccinylase activity IDA
IDA: 通过直接分析推断
27436229 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA damage response IDA
IDA: 通过直接分析推断
30944854 GOA
involved in DNA repair-dependent chromatin remodeling IDA
IDA: 通过直接分析推断
27436229 GOA
involved in R-loop processing IDA
IDA: 通过直接分析推断
28790157 GOA
involved in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IDA
IDA: 通过直接分析推断
28147277 GOA
involved in negative regulation of protein ubiquitination IDA
IDA: 通过直接分析推断
28886238 GOA
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22722849 GOA
involved in positive regulation of gluconeogenesis IMP
IMP: 通过突变表型推断
28655758 GOA
involved in positive regulation of rRNA processing IDA
IDA: 通过直接分析推断
26867678 GOA
involved in positive regulation of transcription by RNA polymerase I IDA
IDA: 通过直接分析推断
30540930 GOA
involved in protein deacetylation IDA
IDA: 通过直接分析推断
24207024 GOA
involved in protein deglutarylation IDA
IDA: 通过直接分析推断
31542297 GOA
involved in rRNA transcription IMP
IMP: 通过突变表型推断
19174463 GOA
involved in regulation of DNA repair IDA
IDA: 通过直接分析推断
30944854 GOA
involved in regulation of mitochondrion organization IMP
IMP: 通过突变表型推断
30420520 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
28426094 GOA
involved in regulation of transcription of nucleolar large rRNA by RNA polymerase I IDA
IDA: 通过直接分析推断
24207024 GOA
involved in transcription initiation-coupled chromatin remodeling IDA
IDA: 通过直接分析推断
28655758 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromatin IDA
IDA: 通过直接分析推断
30944854 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
16079181 GOA
located in nucleolus organizer region IDA
IDA: 通过直接分析推断
19174463 GOA
located in nucleoplasm IDA
IDA: 通过直接分析推断
24207024 GOA
is active in nucleus IDA
IDA: 通过直接分析推断
36646384 GOA
located in nucleus IDA
IDA: 通过直接分析推断
31075303 GOA
located in site of double-strand break IDA
IDA: 通过直接分析推断
27436229 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SIRT7 蛋白结构

SIR2

SIR2: Sir2 family (141 - 274)

  • 0
  • 100
  • 200
  • 300
  • 400 a.a.
蛋白主名 其他名称

NAD-dependent protein deacetylase sirtuin-7

NAD-dependent deacetylase sirtuin-7

NAD-dependent protein deacylase sirtuin-7

SIR2-like protein 7

regulatory protein SIR2 homolog 7

silent mating type information regulation 2, S.cerevisiae, homolog 7

sir2-related protein type 7

sirtuin type 7

关联疾病

疾病名称 别名
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Obesity , Susceptibility To

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Diabetes Mellitus, Non-Insulin-Dependent

Type 2 Diabetes

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Mitochondrial Complex I Deficiency, Nuclear Type 1

Mitochondrial Complex I Deficiency

Nadh:Q(1) Oxidoreductase Deficiency

MC1DN1

Nadh-Coenzyme Q Reductase Deficiency

Isolated Mitochondrial Respiratory Chain Complex I Deficiency

Isolated Nadh-Coenzyme Q Reductase Deficiency

Isolated Nadh-Coq Reductase Deficiency

Isolated Nadh-Ubiquinone Reductase Deficiency

Mitochondrial Nadh Dehydrogenase Component Of Complex I, Deficiency Of

Nuclear Type Mitochondrial Complex I Deficiency 1

Isolated Complex I Deficiency

Complex 1 Mitochondrial Respiratory Chain Deficiency

Nadh Coenzyme Q Reductase Deficiency

Complex I Mitochondrial Respiratory Chain Deficiency

Deficiency Of Mitochondrial Nadh Dehydrogenase Component Of Complex I

Nadh:Ubiquinone Oxidoreductase Deficiency

Complex I, Mitochondrial Respiratory Chain, Deficiency Of
Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis

ALS

Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease

ALS1

Amyotrophic Lateral Sclerosis, Susceptibility To

Fals

Lou Gehrig'S Disease

Mnd

Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis
Monckeberg Arteriosclerosis

Monckeberg Medial Calcific Sclerosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-135899 SIRT7 inhibitor 97491 Inhibitor 98.03% 否
HY-159124 YZL-51N Inhibitor / 否
HY-150727 SIRT5 inhibitor 4 Inhibitor / 否
HY-156489 Epigenetic factor-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SIRT7 VGNC VGNC:65161
Canis familiaris SIRT7 VGNC VGNC:46188
Macaca mulatta SIRT7 VGNC VGNC:77487
Mus musculus SIRT7 MGD MGI:2385849
Bos taurus SIRT7 VGNC VGNC:34636
Rattus norvegicus SIRT7 RGD RGD:1305876
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