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  2. MBIP - MAP3K12 binding inhibitory protein 1 Gene

MBIP - MAP3K12 binding inhibitory protein 1 Gene

中文名称:MAP3K12 结合抑制蛋白 1

种属: Homo sapiens

基因 ID: 51562 | 基因类型: protein coding

关于 MBIP

Cytogenetic location: 14q13.3 Genomic coordinates (GRCh38): 14:36,298,564-36,320,637 (from NCBI)

This gene has 10 transcripts (splice variants), 197 orthologues and 3 paralogues. Broad expression in thyroid (RPKM 34.1), lung (RPKM 32.4) and 24 other tissues.

功能概要

实现相同的蛋白质结合活性和蛋白激酶抑制剂活性。参与组蛋白 H3 乙酰化; JNK 级联的正调控;和基因表达的正调控。位于胞质溶胶中;核仁;和核质。 [由基因组资源联盟提供,2022 年 4 月]

Enables identical protein binding activity and protein kinase inhibitor activity. Involved in histone H3 acetylation; positive regulation of JNK cascade; and positive regulation of gene expression. Located in cytosol; nucleolus; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MBIP 基因产物(3)

mRNA Protein Name
NM_001144891.2 NP_001138363.1 MAP3K12-binding inhibitory protein 1 isoform 2
NM_001308110.2 NP_001295039.1 MAP3K12-binding inhibitory protein 1 isoform 3
NM_016586.3 NP_057670.2 MAP3K12-binding inhibitory protein 1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
16189514 GOA
enables protein kinase inhibitor activity IDA
IDA: 通过直接分析推断
10801814 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
18838386 GOA
involved in positive regulation of JNK cascade IDA
IDA: 通过直接分析推断
10801814 GOA
involved in positive regulation of gene expression IDA
IDA: 通过直接分析推断
32963352 GOA
involved in regulation of DNA-templated transcription IMP
IMP: 通过突变表型推断
19936620 GOA
involved in regulation of cell cycle IMP
IMP: 通过突变表型推断
19103755 GOA
involved in regulation of cell division IDA
IDA: 通过直接分析推断
20562830 GOA
involved in regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22055187 GOA
involved in regulation of tubulin deacetylation IMP
IMP: 通过突变表型推断
20562830 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of ATAC complex IDA
IDA: 通过直接分析推断
18838386 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

MAP3K12-binding inhibitory protein 1

MAPK upstream kinase-binding inhibitory protein

MBIP 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MBIP Q9NS73 EGFR Homo sapiens P00533 27956147
种属内
MBIP Q9NS73 EGFR Homo sapiens P00533 27956147
种属内
MBIP Q9NS73 WDR5 Homo sapiens P61964 33961781
种属内
MBIP Q9NS73 TXLNB Homo sapiens Q8N3L3 31515488
种属内
MBIP Q9NS73 KAT14 Homo sapiens Q9H8E8 33961781
种属内
MBIP Q9NS73 KAT14 Homo sapiens Q9H8E8 16189514
种属内
MBIP Q9NS73 SGF29 Homo sapiens Q96ES7 33961781
种属内
MBIP Q9NS73 PLEKHF2 Homo sapiens Q9H8W4 16189514
种属内
MBIP Q9NS73 PLEKHF2 Homo sapiens Q9H8W4 19060904
种属内
MBIP Q9NS73 PLEKHF2 Homo sapiens Q9H8W4 19060904
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 MBIP 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70921 MBIP Protein, Human (His) Q9NS73-1 (M1-P344) ≥95%

关联疾病

疾病名称 别名
Bronchus Adenoma

Bronchial Adenoma

Adenoma Of The Bronchus

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus MBIP MGD MGI:1918320
Bos taurus MBIP VGNC VGNC:31279
Felis catus MBIP VGNC VGNC:80921
Canis familiaris MBIP VGNC VGNC:43055
Macaca mulatta MBIP VGNC VGNC:74543
Rattus norvegicus MBIP RGD RGD:1306310
Others MBIP NCBI