2. Gene
  3. Pbk - PDZ binding kinase Gene

Pbk - PDZ binding kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：PDZ结合激酶

种属: Mus musculus

同用名: TOPK; D14Ertd732e; 2810434B10Rik

基因 ID: 52033 | 基因类型: protein coding

关于 Pbk

Chromosome 14: 66,043,286-66,055,271 forward strand.GRCm39:CM001007.3

This gene has 3 transcripts (splice variants), 208 orthologues and is associated with 8 phenotypes. Biased expression in CNS E11.5 (RPKM 25.9), liver E14 (RPKM 15.6) and 1 other tissues.

功能概要

该基因编码的蛋白可启动蛋白质丝氨酸/苏氨酸激酶活性。作用于多个过程的上游或内部，包括细胞对紫外线的反应；细胞蛋白质代谢过程的负调节；和应激激活的 MAPK 级联的负调节。预测位于核内。以多种结构表达，包括消化系统；泌尿生殖系统；神经系统;呼吸系统;和感觉器官。与人 PBK（PDZ 结合激酶）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables protein serine/threonine kinase activity. Acts upstream of or within several processes, including cellular response to UV; negative regulation of cellular protein metabolic process; and negative regulation of stress-activated MAPK cascade. Predicted to be located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human PBK (PDZ binding kinase). [provided by Alliance of Genome Resources, Apr 2022]

Pbk 基因产物(1)

mRNA Protein Name
NM_023209.2 NP_075698.1 lymphokine-activated killer T-cell-originated protein kinase
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
21715333 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to UV IMP
IMP: 通过突变表型推断
21715333 MGI
acts upstream of or within negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
21715333 MGI
acts upstream of or within negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
21715333 MGI
acts upstream of or within negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
21715333 MGI
acts upstream of or within negative regulation of stress-activated MAPK cascade IMP
IMP: 通过突变表型推断
21715333 MGI
acts upstream of proteasome-mediated ubiquitin-dependent protein catabolic process IMP
IMP: 通过突变表型推断
21715333 MGI
acts upstream of protein phosphorylation IMP
IMP: 通过突变表型推断
21715333 MGI
acts upstream of stress-activated MAPK cascade IMP
IMP: 通过突变表型推断
21715333 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Pbk 蛋白结构

PKc_TOPK

PKc_TOPK: cd14001 (30 - 317)

  • 0
  • 100
  • 200
  • 300
  • 330 a.a.
蛋白主名 其他名称

lymphokine-activated killer T-cell-originated protein kinase

MAPKK-like protein kinase

T-LAK cell-originated protein kinase

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-120346 PBK-IN-9 Inhibitor / 否
HY-RS10101 PBK Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10102 Pbk Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS10103 Pbk Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Pbk NCBI NCBI:55872
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