PIGR - polymeric immunoglobulin receptor Gene

中文名称：多聚免疫球蛋白受体

种属: Homo sapiens

基因 ID: 5284 | 基因类型: protein coding

关于 PIGR

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,928,522-206,946,466 (from NCBI)

This gene has 3 transcripts (splice variants), 115 orthologues and 13 paralogues. Biased expression in duodenum (RPKM 1246.3), colon (RPKM 1042.2) and 5 other tissues.

功能概要

该基因是免疫球蛋白超家族的成员。编码的多聚免疫球蛋白受体结合上皮细胞基底外侧表面的多聚免疫球蛋白分子；然后复合物被运输穿过细胞，在顶端表面被分泌。在免疫球蛋白 A 肾病和该基因中的几个 SNP 之间发现了显着关联。[RefSeq 提供，2009 年 9 月]

This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]

PIGR 基因产物(1)

mRNA	Protein	Name
NM_002644.4	NP_002635.2	polymeric immunoglobulin receptor precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables polymeric immunoglobulin binding	IDA IDA: 通过直接分析推断	32029689	GOA
enables polymeric immunoglobulin receptor activity	IDA IDA: 通过直接分析推断	22022593	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in Fc receptor signaling pathway	IDA IDA: 通过直接分析推断	22022593	GOA
involved in detection of chemical stimulus involved in sensory perception of bitter taste	IDA IDA: 通过直接分析推断	24248522	GOA
involved in epidermal growth factor receptor signaling pathway	IDA IDA: 通过直接分析推断	22022593	GOA
involved in immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	IDA IDA: 通过直接分析推断	9379029	GOA
involved in receptor clustering	IDA IDA: 通过直接分析推断	22022593	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in extracellular space	IDA IDA: 通过直接分析推断	24248522	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	9379029	GOA
part of receptor complex	IDA IDA: 通过直接分析推断	23382219	GOA
part of secretory IgA immunoglobulin complex	IDA IDA: 通过直接分析推断	32029686	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

PIGR 蛋白结构

V-set

0
200
400
600
764 a.a.

蛋白主名

其他名称

polymeric immunoglobulin receptor

hepatocellular carcinoma associated protein TB6

重组 PIGR 蛋白

目录号	产品名	蛋白编号	纯度
HY-P71065	PIGR Protein, Human (HEK293, His)	P01833 (K19-R638, G365S)	≥95%
HY-P73377	PIGR Protein, Human (G365S, HEK293, His)	P01833/NP_002635.2 (K19-R638, G365S)	≥95%

关联疾病

疾病名称

别名

Protein-Energy Malnutrition

PEM	Protein Energy Malnutrition

Iga Glomerulonephritis

Iga Nephropathy	Glomerulonephritis, Iga
Berger'S Iga Or Igg Nephropathy	Focal Glomerulonephritis
Primary Iga Nephropathy	Segmental Glomerulonephritis
Berger Disease	Berger'S Disease
Igan	Nephritis, Iga Type
Nephropathy Iga	Glomerulonephritis Focal
Iga Nephropathy, Susceptibility To	Primary Immunoglobulin A Nephropathy

Immunoglobulin Alpha Deficiency

Iga Deficiency	Gamma-A-Globulin Deficiency
Immunoglobulin A Deficiency

Periampullary Adenocarcinoma

Alcoholic Gastritis

Alcoholic Gastritis, With Hemorrhage	Alcoholic Gastritis, Without Mention Of Hemorrhage
Alcohol Gastritis	Etoh Gastritis

Atrophy Of Prostate

Nasopharyngeal Carcinoma

Malignant Neoplasm Of Nasopharynx	Npc
Nasopharyngeal Cancer	Nasopharyngeal Carcinoma 1
Nasopharynx Carcinoma	Nasopharyngeal Neoplasms
Npca	Carcinoma Of Nasopharynx
Malignant Nasopharyngeal Tumor	Nasopharynx Cancer
Squamous Cell Carcinoma Of The Nasopharynx	Nasopharyngeal Neoplasm
Cancer Of Nasopharynx

Hepatocellular Carcinoma

Liver Cancer	Primary Liver Cancer
HCC	Hepatoma
Malignant Neoplasm Of Liver	Liver Neoplasms
Cancer, Hepatocellular	Liver Cell Carcinoma
Lcc	Hepatoblastoma, Somatic
Hepatic Cancer	Primary Malignant Neoplasm Of Liver
Rare Tumor Of Liver And Intrahepatic Biliary Tract	Hepatocellular Carcinoma, Somatic
Hepatocellular Carcinoma, Childhood Type, Somatic	Hepatocellular Cancer, Somatic
Ca Liver - Primary	Hepatic Neoplasm
Malignant Hepato-Biliary Neoplasm	Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary
Malignant Neoplasm Of Liver, Primary	Malignant Tumor Of Liver
Neoplasm Of Liver	Non-Resectable Primary Hepatic Malignant Neoplasm
Resectable Malignant Neoplasm Of Liver	Resectable Malignant Neoplasm Of The Liver
Primary Liver Carcinoma	Primary Malignant Liver Neoplasm
Primary Cancer Of Liver	Primary Tumor Of The Liver
Rare Tumor Of Liver And Ibt	Hepatocellular Cancer
Neoplasm Of The Liver	Carcinoma, Hepatocellular
Hepatomas	Liver Neoplasm
Liver Carcinoma	Liver And Intrahepatic Biliary Tract Carcinoma
Malignant Hepatobiliary Neoplasm	Adult Primary Hepatocellular Carcinoma
Hepatoblastoma	Carcinoma Of Liver
Malignant Liver Tumour	Malignant Hepatic Tumour

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10500	PIGR Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	PIGR	VGNC	VGNC:75991
Bos taurus	PIGR	VGNC	VGNC:32876
Canis familiaris	PIGR	VGNC	VGNC:44540
Rattus norvegicus	PIGR	RGD	RGD:3328
Mus musculus	PIGR	MGD	MGI:103080
Felis catus	PIGR	VGNC	VGNC:68848
Macaca fascicularis	PIGR	NCBI	NCBI:102137013
Others	PIGR	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

PIGR - polymeric immunoglobulin receptor Gene

关于 PIGR

功能概要

PIGR 基因产物(1)

PIGR 蛋白结构

重组 PIGR 蛋白

关联疾病

直系同源

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PIGR - polymeric immunoglobulin receptor Gene

关于 PIGR

功能概要

PIGR 基因产物(1)

PIGR 蛋白结构

重组 PIGR 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z