1. Gene
  2. SLC37A1 - solute carrier family 37 member 1 Gene

SLC37A1 - solute carrier family 37 member 1 Gene

中文名称:溶质载体家族 37 成员 1

种属: Homo sapiens

同用名: G3PP; SPX1

基因 ID: 54020 | 基因类型: protein coding

关于 SLC37A1

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,499,622-42,581,426 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues and 12 paralogues. Broad expression in duodenum (RPKM 9.6), small intestine (RPKM 8.6) and 23 other tissues.

功能概要

由该基因编码的蛋白质定位于内质网 (ER) 膜。这种蛋白质将葡萄糖-6-磷酸从细胞质转移到 ER 的腔中,以通过另一种 ER 膜蛋白水解成葡萄糖。该基因是溶质载体 37 基因家族的成员。可变剪接导致多个转录本变体。[RefSeq 提供,2016 年 2 月]

The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

SLC37A1 基因产物(2)

mRNA Protein Name
NM_001320537.2 NP_001307466.1 glucose-6-phosphate exchanger SLC37A1
NM_018964.4 NP_061837.3 glucose-6-phosphate exchanger SLC37A1

SLC37A1 蛋白结构

MFS_1

MFS_1: Major Facilitator Superfamily (98 - 450)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 533 a.a.
蛋白主名 其他名称

glucose-6-phosphate exchanger SLC37A1

G-3-P permease

关联疾病

疾病名称 别名
Glycerol Kinase Deficiency

Hyperglycerolemia

GKD

Gk Deficiency

Gk1 Deficiency

Deficiency Of Glycerol Kinase

Isolated Glycerol Kinase Deficiency

Glycerol Kinase Deficiency, Adult Form

Glycerol Kinase Deficiency, Juvenile Form

Deficiency, Glycerol Kinase

Severe Congenital Neutropenia 4

Autosomal Recessive Severe Congenital Neutropenia Due To G6pc3 Deficiency

Scn4

Severe Congenital Neutropenia-Pulmonary Hypertension-Superficial Venous Angiectasis Syndrome

Dursun Syndrome

Severe Congenital Neutropenia Type 4

Deafness, Autosomal Recessive 8

Neurosensory Nonsyndromic Recessive Deafness 8

DFNB8

Dfnb10

Deafness, Autosomal Recessive 10

Deafness, Childhood-Onset Neurosensory, Autosomal Recessive 8

Nsrd8

Autosomal Recessive Nonsyndromic Deafness 8

Deafness, Autosomal Recessive 8/10

Autosomal Recessive Deafness 10

Autosomal Recessive Deafness 8

Childhood-Onset Neurosensory Autosomal Recessive Deafness 8

Nrsd8

Deafness, Autosomal Recessive, 8

Childhood-Onset Neurosensory Deafness Autosomal Recessive 8

Deafness Autosomal Recessive 10

Deafness Autosomal Recessive 8/10

Deafness Neurosensory Autosomal Recessive 8

Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 8

Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 8

Deafness, Autosomal Recessive, Type 8/10

Glycogen Storage Disease

Glycogenosis

Glycogenoses

Gsd

Storage Disease, Glycogen

Gsd - [Glycogen Storage Disease]

Glycogen Thesaurismosis

Diffuse Glycogenosis

Generalised Glycogen Storage Disease

Generalised Glycogenosis

Generalised Glycogen Storage Disease Of Infants

Glycogen Synthase Deficiency

Glycogen Storage Disease Ia

Von Gierke Disease

Glycogen Storage Disease Type I

Glycogen Storage Disease I

Hepatorenal Form Of Glycogen Storage Disease

Hepatorenal Glycogenosis

Glucose-6-Phosphatase Deficiency

Glycogen Storage Disease, Type I

Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia

GSD1A

Gsd1

Von Gierke'S Disease

Glycogen Storage Disease Type 1a

Glycogen Storage Disease 1a

Glucose-6-Phosphate Transport Defect

Gsd Ia

Deficiency Of Glucose-6-Phosphatase

Glycogenosis Type I

Glucose-6-Phosphatase Deficiency Glycogen Storage Disease

Glycogenosis Type 1

Glucose-6-Phosphate Deficiency

Gsd I

Gsd Type I

G6p Deficiency Type 1a

Gsd Due To G6p Deficiency Type 1a

Gsd Due To G6p Deficiency Type Ia

Gsd Type 1a

Gsdia

Glycogen Storage Disease Due To G6p Deficiency Type Ia

Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a

Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia

Glycogenosis Type Ia

Gsd-Ia

Storage Disease, Glycogen, Type 1a

Glycogen Storage Disease Type Ia

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC37A1 MGD MGI:2446181
Rattus norvegicus SLC37A1 RGD RGD:1308587
Felis catus SLC37A1 VGNC VGNC:97631
Bos taurus SLC37A1 VGNC VGNC:34842
Canis familiaris SLC37A1 VGNC VGNC:46386
Macaca mulatta SLC37A1 VGNC VGNC:81573