DCUN1D1 - defective in cullin neddylation 1 domain containing 1 Gene

中文名称：含缺陷 cullin neddylation 1 结构域 1

种属: Homo sapiens

同用名: RP42; SCRO; Tes3; DCNL1; SCCRO; DCUN1L1

基因 ID: 54165 | 基因类型: protein coding

关于 DCUN1D1

Cytogenetic location: 3q26.33 Genomic coordinates (GRCh38): 3:182,938,074-182,985,918 (from NCBI)

This gene has 8 transcripts (splice variants), 217 orthologues and 4 paralogues. Broad expression in testis (RPKM 16.2), bone marrow (RPKM 6.8) and 24 other tissues.

功能概要

启用 cullin 家族蛋白结合活性。参与蛋白质 neddylation 的正调控和蛋白质泛素化的调控。位于细胞质和核质中。泛素连接酶复合物的一部分。 [由基因组资源联盟提供，2022 年 4 月]

Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation and regulation of protein ubiquitination. Located in cytosol and nucleoplasm. Part of ubiquitin Ligase complex. [provided by Alliance of Genome Resources, Apr 2022]

DCUN1D1 基因产物(2)

mRNA	Protein	Name
NM_001308101.2	NP_001295030.1	DCN1-like protein 1 isoform 2
NM_020640.4	NP_065691.2	DCN1-like protein 1 isoform 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cullin family protein binding	IMP IMP: 通过突变表型推断	19617556	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in positive regulation of protein neddylation	IMP IMP: 通过突变表型推断	23201271	GOA
involved in regulation of protein neddylation	IMP IMP: 通过突变表型推断	19617556	GOA
involved in regulation of protein ubiquitination	IMP IMP: 通过突变表型推断	23401859	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IMP IMP: 通过突变表型推断	26906416	GOA
located in nucleus	IMP IMP: 通过突变表型推断	26906416	GOA
part of ubiquitin ligase complex	IDA IDA: 通过直接分析推断	18826954	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

DCUN1D1 蛋白结构

UBA_4

Cullin_binding

0
100
200
259 a.a.

蛋白主名

其他名称

DCN1-like protein 1

DCN1, defective in cullin neddylation 1, domain containing 1

DCUN1D1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	DCUN1D1	Q96GG9	TP53BP2	Homo sapiens	Q13625-3	Y2H Array	25416956
种属内	DCUN1D1	Q96GG9	TP53BP2	Homo sapiens	Q13625-3	Y2H Prey Pooling	25416956
种属内	DCUN1D1	Q96GG9	UBE2M	Homo sapiens	P61081	TAP	21145461
种属内	DCUN1D1	Q96GG9	UBE2M	Homo sapiens	P61081	Anti Tag CoIP	19617556
种属内	DCUN1D1	Q96GG9	ABRAXAS2	Homo sapiens	Q15018	Y2H Array	32296183
种属内	DCUN1D1	Q96GG9	ABRAXAS2	Homo sapiens	Q15018	Y2H Prey Pooling	32296183
种属内	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	27107012
种属内	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Prey Pooling	32296183
种属内	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9-2	Validated Y2H	32296183
种属内	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9-2	BFG-2H	27107012
种属内	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9-2	Y2H Array	32296183
种属内	DCUN1D1	Q96GG9	TMEM239	Homo sapiens	Q8WW34-2	Y2H Prey Pooling	32296183
种属内	DCUN1D1	Q96GG9	TMEM239	Homo sapiens	Q8WW34-2	Y2H Array	32296183
种属内	DCUN1D1	Q96GG9	FAM168A	Homo sapiens	Q92567-2	Y2H Prey Pooling	32296183
种属内	DCUN1D1	Q96GG9	FAM168A	Homo sapiens	Q92567-2	Y2H Array	32296183
种属内	DCUN1D1	Q96GG9	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	25416956
种属内	DCUN1D1	Q96GG9	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	25416956
种属内	DCUN1D1	Q96GG9	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	25416956
种属内	DCUN1D1	Q96GG9	TRIM8	Homo sapiens	Q9BZR9	Y2H Prey Pooling	32296183
种属内	DCUN1D1	Q96GG9	TRIM8	Homo sapiens	Q9BZR9	Y2H Array	32296183
种属内	DCUN1D1	Q96GG9	TRIM8	Homo sapiens	Q9BZR9	Validated Y2H	32296183
种属内	DCUN1D1	Q96GG9	SUSD6	Homo sapiens	Q92537	Y2H Array	32296183
种属内	DCUN1D1	Q96GG9	SUSD6	Homo sapiens	Q92537	Y2H Prey Pooling	32296183
种属内	DCUN1D1	Q96GG9	ARRDC3	Homo sapiens	Q96B67	Y2H Array	32296183
种属内	DCUN1D1	Q96GG9	ARRDC3	Homo sapiens	Q96B67	Y2H Prey Pooling	32296183
种属内	DCUN1D1	Q96GG9	ARRDC3	Homo sapiens	Q96B67	Validated Y2H	25416956
种属内	DCUN1D1	Q96GG9	CDIP1	Homo sapiens	Q9H305	Validated Y2H	32296183
种属内	DCUN1D1	Q96GG9	CDIP1	Homo sapiens	Q9H305	Y2H Array	32296183
种属内	DCUN1D1	Q96GG9	CDIP1	Homo sapiens	Q9H305	Y2H Prey Pooling	32296183
种属内	DCUN1D1	Q96GG9	PLEKHB2	Homo sapiens	Q96CS7	Y2H Array	32296183
种属内	DCUN1D1	Q96GG9	PLEKHB2	Homo sapiens	Q96CS7	Y2H Prey Pooling	32296183
种属内	DCUN1D1	Q96GG9	DAZAP2	Homo sapiens	Q15038	Validated Y2H	25416956
种属内	DCUN1D1	Q96GG9	DAZAP2	Homo sapiens	Q15038	Y2H Array	25416956
种属内	DCUN1D1	Q96GG9	DAZAP2	Homo sapiens	Q15038	Y2H Array	32296183
种属内	DCUN1D1	Q96GG9	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	32296183
种属内	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9	Y2H Pooling	16189514
种属内	DCUN1D1	Q96GG9	TRIM39	Homo sapiens	Q9HCM9	Y2H Array	25416956
种属内	DCUN1D1	Q96GG9	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	32296183
种属内	DCUN1D1	Q96GG9	LZTS2	Homo sapiens	Q9BRK4	Y2H Prey Pooling	32296183
种属内	DCUN1D1	Q96GG9	LZTS2	Homo sapiens	Q9BRK4	Validated Y2H	32296183
种属内	DCUN1D1	Q96GG9	LZTS2	Homo sapiens	Q9BRK4	Y2H Array	25416956
种属内	DCUN1D1	Q96GG9	GMPPA	Homo sapiens	Q96IJ6	Y2H Prey Pooling	32296183
种属内	DCUN1D1	Q96GG9	GMPPA	Homo sapiens	Q96IJ6	Validated Y2H	32296183
种属内	DCUN1D1	Q96GG9	GMPPA	Homo sapiens	Q96IJ6	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 DCUN1D1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70093	DCN1-like protein 1/DCUN1D1 Protein, Human (His)	Q96GG9 (M1-V259)	≥95%

关联疾病

疾病名称

别名

Squamous Cell Carcinoma

Epidermoid Carcinoma	Squamous Cell Cancer
Carcinoma, Squamous Cell	Squamous Cell Skin Cancer
Malignant Squamous Cell Tumor	Squamous Carcinoma
Squamous Cell Epithelioma	Carcinoma Squamous Cell
Neoplasms, Squamous Cell	Squamous Cell Carcinoma - Category
Malignant Squamous Cell Neoplasm	Squamous Cell Carcinoma Of Skin

Scrotum Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Scrotum

Scrotal Squamous Cell Carcinoma

Scrotal Carcinoma

Carcinoma Of Scrotum	Malignant Neoplasm Of Scrotum
Neoplasm Of Scrotum

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03598	DCUN1D1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	DCUN1D1	VGNC	VGNC:102688
Rattus norvegicus	DCUN1D1	RGD	RGD:1309668
Canis familiaris	DCUN1D1	VGNC	VGNC:39822
Bos taurus	DCUN1D1	VGNC	VGNC:27935
Mus musculus	DCUN1D1	MGD	MGI:2150386
Macaca mulatta	DCUN1D1	VGNC	VGNC:84194
Others	DCUN1D1	NCBI

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