POLR2J3 - RNA polymerase II subunit J3 Gene

中文名称：RNA 聚合酶 II 亚基 J3

种属: Homo sapiens

同用名: RPB11b2

关于 POLR2J3

功能概要

该基因是 RNA 聚合酶 II 亚基 11 基因家族的成员，该家族包括染色体 7q22.1 上簇中的三个基因和染色体 7p13 上的假基因。该家族的创始成员，DNA 指导的 RNA 聚合酶 II 多肽 J，已被证明编码 RNA 聚合酶 II 的一个亚基，该聚合酶负责在真核生物中合成信使 RNA。与 DNA 指导的 RNA 聚合酶 II 多肽 J 相比，该基因座产生多个选择性剪接的转录本，这些转录本可能表达具有不同 C 末端的同种型。大多数或所有变体被剪接以在 3' 末端包括额外的非编码外显子，这使它们成为候选者无意义介导的衰变 (NMD) 。因此，不知道该位点是否在体内表达一种或多种蛋白质。[RefSeq 提供，2008 年 7 月]

This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]