AUP1 - AUP1 lipid droplet regulating VLDL assembly factor Gene

中文名称：AUP1 脂滴调节 VLDL 装配因子

种属: Homo sapiens

关于 AUP1

功能概要

编码该基因的蛋白质参与多种途径，包括内质网中错误折叠蛋白质的质量控制和脂滴积累。脂滴是细胞质中的细胞器，可储存中性脂质，如胆固醇酯和甘油三酯，以防止细胞中游离胆固醇和脂肪酸过多，同时也可作为其他代谢过程 (如膜生物合成) 的储存库。该基因的表达减少导致脂滴聚集减少，这是一种依赖于蛋白质泛素化的功能。该蛋白质包含多个结构域，包括疏水性 N 末端结构域、乙酰转移酶结构域、泛素结合 CUE 结构域和 UBE2B2 结合结构域 (G2BR) 。可变剪接导致多个转录本变体。[RefSeq 提供，2014 年 11 月]

The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as Cholesterol esters and trigylycerides to prevent the overabundance of free Cholesterol and fatty acids in cells, but also to act as storage for Other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]