2. Gene
  3. SLC38A4 - solute carrier family 38 member 4 Gene

SLC38A4 - solute carrier family 38 member 4 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：溶质载体家族 38 成员 4

种属: Homo sapiens

同用名: ATA3; NAT3; PAAT; SNAT4

基因 ID: 55089 | 基因类型: protein coding

关于 SLC38A4

Cytogenetic location: 12q13.11 Genomic coordinates (GRCh38): 12:46,764,761-46,832,431 (from NCBI)

This gene has 5 transcripts (splice variants), 218 orthologues and 15 paralogues. Restricted expression toward liver (RPKM 138.1).

功能概要

SLC38A4 主要存在于肝脏中并转运阳离子和中性氨基酸。 SLC38A4 对阳离子氨基酸的转运与 Na (+) 和 pH 无关，而中性氨基酸的转运与 Na (+) 和 pH 相关 (Hatanaka 等人，2001 [PubMed 11342143]) 。[OMIM 提供， 2008 年 3 月]

SLC38A4 is found predominantly in liver and transports both cationic and neutral Amino acids. The transport of cationic Amino acids by SLC38A4 is Na(+) and pH independent, while the transport of neutral Amino acids is Na(+) and pH dependent (Hatanaka et al., 2001 [PubMed 11342143]).[supplied by OMIM, Mar 2008]

SLC38A4 基因产物(2)

mRNA Protein Name
NM_001143824.2 NP_001137296.1 sodium-coupled neutral amino acid transporter 4
NM_018018.5 NP_060488.2 sodium-coupled neutral amino acid transporter 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alanine:sodium symporter activity IDA
IDA: 通过直接分析推断
11414754 GOA
enables amino acid:sodium symporter activity IDA
IDA: 通过直接分析推断
33928121 GOA
enables neutral L-amino acid:sodium symporter activity IDA
IDA: 通过直接分析推断
11342143 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
32296183 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in L-alanine import across plasma membrane IDA
IDA: 通过直接分析推断
11414754 GOA
involved in neutral amino acid transport IDA
IDA: 通过直接分析推断
11342143 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in microvillus membrane IDA
IDA: 通过直接分析推断
19015196 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC38A4 蛋白结构

Aa_trans

Aa_trans: Transmembrane amino acid transporter protein (74 - 245)

Aa_trans

Aa_trans: Transmembrane amino acid transporter protein (324 - 534)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 547 a.a.
蛋白主名 其他名称

sodium-coupled neutral amino acid transporter 4

N amino acid transporter 3

SLC38A4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SLC38A4 Q969I6 GJA8 Homo sapiens P48165
Y2H Prey Pooling
32296183
种属内
SLC38A4 Q969I6 GJA8 Homo sapiens P48165
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mahvash Disease

Gcgr-Related Hyperglucagonemia

MVAH

Alpha-Cell Hyperplasia With Glucagonemia

Nesidioblastosis, Alpha Cell Hyperplasia, Microglucagonoma, And Nonfunctioning Islet Cell Tumor

Nesidioblastosis Alpha Cell Hyperplasia Microglucagonoma And Nonfunctioning Islet Cell Tumor
Ciliary Dyskinesia, Primary, 30

Primary Ciliary Dyskinesia 30

CILD30

Ciliary Dyskinesia, Primary, 30, With Or Without Situs Inversus

Primary Ciliary Dyskinesia 30 Without Situs Inversus

Primary Ciliary Dyskinesia 30 With Or Without Situs Inversus

Dyskinesia, Ciliary, Primary, Type 30
Persistent Fetal Circulation Syndrome

Persistent Fetal Circulation

Fetal Circulation

Persistent Pulmonary Hypertension Of The Newborn

Congenital Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins

Persistent Foetal Circulation

Persistent Foetal Circulation Syndrome

Pfc - [Persistent Fetal Circulation] Syndrome

Pphn - [Persistent Pulmonary Hypertension Of The Newborn]

Newborn Pulmonary Hypertension

Primary Pulmonary Hypertension Of Newborn
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13222 SLC38A4 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus SLC38A4 MGD MGI:1916604
Macaca mulatta SLC38A4 VGNC VGNC:77484
Felis catus SLC38A4 VGNC VGNC:65347
Bos taurus SLC38A4 VGNC VGNC:34851
Canis familiaris SLC38A4 VGNC VGNC:46395
Rattus norvegicus SLC38A4 RGD RGD:621836
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