1. Gene
  2. WRAP53 - WD repeat containing antisense to TP53 Gene

WRAP53 - WD repeat containing antisense to TP53 Gene

中文名称:含 WD 重复序列的 TP53 反义序列

种属: Homo sapiens

同用名: DKCB3; TCAB1; WDR79

基因 ID: 55135 | 基因类型: protein coding

关于 WRAP53

Cytogenetic location: 17p13.1 Genomic coordinates (GRCh38): 17:7,686,071-7,703,502 (from NCBI)

This gene has 16 transcripts (splice variants), 190 orthologues and is associated with 3 phenotypes. Ubiquitous expression in lymph node (RPKM 2.8), testis (RPKM 2.5) and 25 other tissues.

功能概要

该基因编码端粒酶全酶复合物的重要成分,端粒合成所需的核糖核蛋白复合物。这种蛋白质富含 Cajal 体,RNP 加工的核位点对端粒酶功能很重要。它与肌张力蛋白、TERT 和 TERC、活性端粒酶的其他成分以及参与修饰剪接 RNA 的小 Cajal 体 RNA (scaRNA) 相互作用。该 mRNA 还用作 p53 反义转录本,调节内源性 p53 mRNA 水平并通过靶向 p53 mRNA 的 5' 非翻译区进一步诱导 p53 蛋白。已发现该基因的选择性剪接转录物变体,其差异仅在于 5' UTR。[RefSeq 提供,2011 年 3 月]

This gene encodes an essential component of the Telomerase holoenzyme complex, a ribonucleoprotein complex required for telomere synthesis. This protein is enriched in Cajal bodies, nuclear sites of RNP processing that are important for Telomerase function. It interacts with dyskerin, TERT and TERC, Other components of active Telomerase, and with small Cajal body RNAs (scaRNAs), which are involved in modifying splicing RNAs. This mRNA also functions as a p53 antisense transcript, that regulates endogenous p53 mRNA levels and further induction of p53 protein by targeting the 5' untranslated region of p53 mRNA. Alternatively spliced transcript variants which differ only in the 5' UTR have been found for this gene. [provided by RefSeq, Mar 2011]

WRAP53 基因产物(4)

mRNA Protein Name
NM_001143990.2 NP_001137462.1 telomerase Cajal body protein 1
NM_001143991.2 NP_001137463.1 telomerase Cajal body protein 1
NM_001143992.2 NP_001137464.1 telomerase Cajal body protein 1
NM_018081.2 NP_060551.2 telomerase Cajal body protein 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables RNA binding IDA
IDA: 通过直接分析推断
19179534 GOA
enables RNA binding IPI
IPI: 通过物理相互作用推断
20351177 GOA
enables RNA folding chaperone IDA
IDA: 通过直接分析推断
19179534 GOA
enables histone binding IPI
IPI: 通过物理相互作用推断
26734725 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
21072240 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19179534 GOA
enables protein carrier chaperone IMP
IMP: 通过突变表型推断
25467444 GOA
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
25467444 GOA
enables protein-folding chaperone binding IPI
IPI: 通过物理相互作用推断
25467444 GOA
enables telomerase RNA binding IDA
IDA: 通过直接分析推断
22547674 GOA
enables telomerase RNA binding IPI
IPI: 通过物理相互作用推断
20351177 GOA
enables ubiquitin protein ligase binding IPI
IPI: 通过物理相互作用推断
25512560 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Cajal body organization IMP
IMP: 通过突变表型推断
21072240 GOA
involved in RNA folding IDA
IDA: 通过直接分析推断
29804836 GOA
involved in positive regulation of DNA repair IDA
IDA: 通过直接分析推断
25512560 GOA
involved in positive regulation of double-strand break repair IDA
IDA: 通过直接分析推断
27715493 GOA
involved in positive regulation of double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
25512560 GOA
involved in positive regulation of double-strand break repair via nonhomologous end joining IDA
IDA: 通过直接分析推断
25512560 GOA
involved in positive regulation of establishment of protein localization to telomere IMP
IMP: 通过突变表型推断
25467444 GOA
acts upstream of positive regulation of telomere maintenance via telomerase IDA
IDA: 通过直接分析推断
23685356 GOA
involved in protein localization to Cajal body IDA
IDA: 通过直接分析推断
22547674 GOA
involved in scaRNA localization to Cajal body IDA
IDA: 通过直接分析推断
19285445 GOA
involved in scaRNA localization to Cajal body IMP
IMP: 通过突变表型推断
25467444 GOA
involved in telomerase RNA localization to Cajal body IMP
IMP: 通过突变表型推断
25467444 GOA
involved in telomere formation via telomerase IMP
IMP: 通过突变表型推断
19179534 GOA
involved in telomere maintenance via telomerase IDA
IDA: 通过直接分析推断
29695869 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Cajal body IDA
IDA: 通过直接分析推断
19179534 GOA
located in Cajal body IMP
IMP: 通过突变表型推断
25467444 GOA
located in site of double-strand break IDA
IDA: 通过直接分析推断
25512560 GOA
part of telomerase holoenzyme complex IDA
IDA: 通过直接分析推断
19179534 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

WRAP53 蛋白结构

WD40

WD40: WD domain, G-beta repeat (170 - 197)

WD40

WD40: WD domain, G-beta repeat (322 - 349)

WD40

WD40: WD domain, G-beta repeat (358 - 387)

WD40

WD40: WD domain, G-beta repeat (421 - 441)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 548 a.a.
蛋白主名 其他名称

telomerase Cajal body protein 1

WD repeat-containing protein 79

WRAP53 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
WRAP53 Q9BUR4 VAC14 Homo sapiens Q08AM6 32296183
种属内
WRAP53 Q9BUR4 VAC14 Homo sapiens Q08AM6 32296183
种属内
WRAP53 Q9BUR4 UBAP2 Homo sapiens Q5T6F2 32296183
种属内
WRAP53 Q9BUR4 UBAP2 Homo sapiens Q5T6F2 32296183
种属内
WRAP53 Q9BUR4 DKC1 Homo sapiens O60832 19179534
种属内
WRAP53 Q9BUR4 CCT2 Homo sapiens P78371 25467444
种属内
WRAP53 Q9BUR4 CCT3 Homo sapiens P49368 25467444
种属内
WRAP53 Q9BUR4 CCT2 Homo sapiens P78371 25467444
种属内
WRAP53 Q9BUR4 CCT3 Homo sapiens P49368 25467444
种属内
WRAP53 Q9BUR4 TCP1 Homo sapiens P17987 25467444
种属内
WRAP53 Q9BUR4 CCT3 Homo sapiens P49368 26496610
种属内
WRAP53 Q9BUR4 DKC1 Homo sapiens O60832 25467444
种属内
WRAP53 Q9BUR4 CCT2 Homo sapiens P78371 26496610
种属内
WRAP53 Q9BUR4 TCP1 Homo sapiens P17987 25467444
种属内
WRAP53 Q9BUR4 DKC1 Homo sapiens O60832 26496610
种属内
WRAP53 Q9BUR4 SMN1 Homo sapiens Q16637 21072240
种属内
WRAP53 Q9BUR4 SMN1 Homo sapiens Q16637 21072240
种属内
WRAP53 Q9BUR4 COIL Homo sapiens P38432 21072240
种属内
WRAP53 Q9BUR4 COIL Homo sapiens P38432 21072240
种属间
WRAP53 Q9BUR4 CCT6 Oryctolagus cuniculus O77622 25467444
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Dyskeratosis Congenita, Autosomal Recessive 3

DKCB3

Autosomal Recessive Dyskeratosis Congenita 3

Dyskeratosis Congenita, Autosomal Recessive, 3

Dyskeratosis Congenita, Autosomal Recessive, Type 3

Li-Fraumeni Syndrome

Sarcoma Family Syndrome Of Li And Fraumeni

Sbla Syndrome

LFS

Li-Fraumeni Familiar Cancer Susceptibility Syndrome

Sarcoma, Breast, Leukaemia And Adrenal Gland Syndrome

Lfs1

Li Fraumeni Syndrome

Sarcoma, Breast, Leukemia, And Adrenal Gland Syndrome

Lfl

Sbla Syndrome Li-Fraumeni-Like Syndrome

Li-Fraumeni Syndrome 1

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant

Dc

Dkc

Zinsser-Engman-Cole Syndrome

Dyskeratosis Congenita, Autosomal Dominant

Autosomal Dominant Dyskeratosis Congenita

Dkca

Dyskeratosis Congenita Scoggins Type

Zinsser-Cole-Engman Syndrome

X-Linked Dyskeratosis Congenita

Hoyeraal-Hreidarsson Syndrome

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Revesz Syndrome

Exudative Retinopathy With Bone Marrow Failure

DKCA5

Dyskeratosis Congenita, Autosomal Dominant 5

Dyskeratosis Congenita With Bilateral Exudative Retinopathy

Retinopathy-Anemia-Central Nervous System Anomalies Syndrome

Revesz-Debuse Syndrome

Dyskeratosis Congenita, Autosomal Dominant, 5

Revesz Debuse Syndrome

Dyskeratosis Congenita Autosomal Recessive

Autosomal Recessive Dyskeratosis Congenita

Dkcb

Dyskeratosis Congenita, Autosomal Recessive

Aplastic Anemia

Aplastic Anemia, Susceptibility To

Anemia Aplastic

Idiopathic Aplastic Anemia

Secondary Aplastic Anemia

Idiopathic Bone Marrow Failure

Aplastic Anemia Idiopathic

AA

Anemia, Aplastic

Aplastic Anemia, Idiopathic

Erythroid Aplasia

Aa - [Aplastic Anaemia]

Haematopoietic Aplasia

Aleukia Haemorrhagica

Anaemia Due To Decreased Red Cell Production

Aplasia Bone Marrow

Aplastic Bone Marrow

Hypoplastic Anaemia Nos

Myeloid Bone Marrow Aplasia

Pancytopenia

Panhaematopenia

Hypoproliferative Anaemia

Medullary Hypoplasia

Red Blood Cells Hypoplastic Anaemia

Panmyelophthisis

Panhemocytopenia

Refractive Hypoproliferative Anaemia

Toxic Anaemia

Toxic Aplastic Anaemia

Aplastic Anaemia Due To Toxic Cause

Idiopathic Aplastic Anaemia Nos

Dyskeratosis Congenita, Autosomal Dominant 1

DKCA1

Dyskeratosis Congenita, Scoggins Type

Autosomal Dominant Dyskeratosis Congenita 1

Dyskeratosis Congenita, Autosomal Dominant, Type 1

Dyskeratosis Congenita, Autosomal Dominant

Retinal Telangiectasia
Coats Disease

Exudative Retinopathy

Retinal Telangiectasis

Coats' Disease

Leber Miliary Aneurysm

Coats' Syndrome

Congenital Retinal Telangiectasia

Entropion
Melanoma, Cutaneous Malignant 1

Familial Melanoma

Melanoma, Cutaneous Malignant, Susceptibility To, 1

Melanoma, Malignant

CMM1

Melanoma, Cutaneous Malignant

Cmm

Familial Atypical Mole-Malignant Melanoma Syndrome

Fammm

Melanoma, Familial

Mlm

Dysplastic Nevus Syndrome, Hereditary

Dns

B-K Mole Syndrome

Melanoma, Cutaneous Malignant, 1

Malignant Melanoma, Cutaneous

Melanoma, Cutaneous, Malignant, Susceptibility To, Type 1

Dysplastic Nevus Syndrome

Cutaneous Melanoma

Familial Atypical Mole Melanoma Syndrome

Hereditary Melanoma

Diamond-Blackfan Anemia

Congenital Pure Red Cell Aplasia

Aase Syndrome

Erythrogenesis Imperfecta

Anemia, Diamond-Blackfan

Congenital Hypoplastic Anemia

Aase-Smith Ii Syndrome

Bds

Blackfan-Diamond Anemia

Congenital Prca

Congenital Hypoplastic Anemia, Blackfan-Diamond Type

Dba

Blackfan - Diamond Syndrome

Chronic Constitutional Pure Red Cell Anaemia

Anemia Diamond Blackfan Type

Anemia Congenital Erythroid Hypoplastic

Aregenerative Anemia Chronic Congenital

Blackfan Diamond Syndrome

Red Cell Aplasia, Pure Hereditary

Aase-Smith Syndrome Ii

Bda

Blackfan Diamond Anemia

Blackfan-Diamond Disease

Blackfan-Diamond Syndrome

Chronic Congenital Agenerative Anemia

Congenital Erythroid Hypoplastic Anemia

Congenital Hypoplastic Anemia Of Blackfan And Diamond

Congenital Pure Red Cell Anemia

Hypoplastic Congenital Anemia

Inherited Erythroblastopenia

Pure Hereditary Red Cell Aplasia

Anemia, Hypoplastic, Congenital

Anemia Hypoplastic Congenital

Fanconi Anemia

Constitutional Aplastic Anemia

Diamond-Blackfan Anemia 1

Aase Smith Syndrome 2

Congenital Red Cell Aplasia

Red Cell Aplasia Of Infants

Pure Red Cell Aplasia Of Infants

Congenital Red Cell Aplastic Anaemia

Congenital Pure Red Cell Anaemia

Congenital Erythroid Hypoplasia

Pearson Marrow-Pancreas Syndrome

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta WRAP53 VGNC VGNC:79508
Bos taurus WRAP53 VGNC VGNC:36968
Rattus norvegicus WRAP53 RGD RGD:1359624
Canis familiaris WRAP53 VGNC VGNC:48432
Mus musculus WRAP53 MGD MGI:2384933
Felis catus WRAP53 VGNC VGNC:67088