2. Gene
  3. EXD2 - exonuclease 3'-5' domain containing 2 Gene

EXD2 - exonuclease 3'-5' domain containing 2 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：含核酸外切酶 3'-5' 结构域 2

种属: Homo sapiens

同用名: EXDL2; C14orf114

基因 ID: 55218 | 基因类型: protein coding

关于 EXD2

Cytogenetic location: 14q24.1 Genomic coordinates (GRCh38): 14:69,191,498-69,244,018 (from NCBI)

This gene has 14 transcripts (splice variants), 203 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 9.7), brain (RPKM 8.0) and 25 other tissues.

功能概要

启用 3'-5' 核酸外切酶活性；金属离子结合活性；和蛋白质同二聚化活性。参与核酸代谢过程。位于中间丝细胞骨架；线粒体外膜；和 DNA 损伤部位。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3'-5' exonuclease activity; metal ion binding activity; and protein homodimerization activity. Involved in nucleic acid metabolic process. Located in intermediate filament cytoskeleton; mitochondrial outer membrane; and site of DNA damage. [provided by Alliance of Genome Resources, Apr 2022]

EXD2 基因产物(5)

mRNA Protein Name
NM_001193360.2 NP_001180289.1 exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_001193361.2 NP_001180290.1 exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_001193362.2 NP_001180291.1 exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_001193363.2 NP_001180292.1 exonuclease 3'-5' domain-containing protein 2 isoform 1
NM_018199.4 NP_060669.1 exonuclease 3'-5' domain-containing protein 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3'-5' exonuclease activity IDA
IDA: 通过直接分析推断
26807646 GOA
enables 3'-5' exonuclease activity IMP
IMP: 通过突变表型推断
31255466 GOA
enables 3'-5'-DNA exonuclease activity IDA
IDA: 通过直接分析推断
31127291 GOA
enables 3'-5'-RNA exonuclease activity IDA
IDA: 通过直接分析推断
31127291 GOA
enables magnesium ion binding IDA
IDA: 通过直接分析推断
31127291 GOA
enables manganese ion binding IDA
IDA: 通过直接分析推断
31127291 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
26807646 GOA
enables protein homodimerization activity IDA
IDA: 通过直接分析推断
31127291 GOA
enables single-stranded DNA 3'-5' DNA exonuclease activity IDA
IDA: 通过直接分析推断
26807646 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in DNA double-strand break processing IDA
IDA: 通过直接分析推断
26807646 GOA
involved in double-strand break repair IDA
IDA: 通过直接分析推断
26807646 GOA
involved in double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
26807646 GOA
involved in nucleic acid metabolic process IDA
IDA: 通过直接分析推断
26807646 GOA
involved in replication fork processing IMP
IMP: 通过突变表型推断
31255466 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial outer membrane IDA
IDA: 通过直接分析推断
29599527 GOA
located in site of DNA damage IDA
IDA: 通过直接分析推断
31255466 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

EXD2 蛋白结构

DNA_pol_A_exo1

DNA_pol_A_exo1: 3'-5' exonuclease (96 - 257)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 621 a.a.
蛋白主名 其他名称

exonuclease 3'-5' domain-containing protein 2

3'-5' exoribonuclease EXD2

EXD2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
EXD2 Q9NVH0 RBBP8 Homo sapiens Q99708
Anti Tag CoIP
26807646
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Hereditary Breast Ovarian Cancer Syndrome

Hereditary Breast And Ovarian Cancer Syndrome

Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer

Breast And/Or Ovarian Cancer

Breast And Ovarian Cancer Syndrome

Hboc Syndrome

Hereditary Breast And Ovarian Cancer

Brca1- Brca2-Associated Hboc
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS04583 EXD2 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus EXD2 RGD RGD:1311087
Macaca mulatta EXD2 VGNC VGNC:81401
Canis familiaris EXD2 VGNC VGNC:40509
Felis catus EXD2 VGNC VGNC:80976
Bos taurus EXD2 VGNC VGNC:28640
Mus musculus EXD2 MGD MGI:1922485
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