2. Gene
  3. MNS1 - meiosis specific nuclear structural 1 Gene

MNS1 - meiosis specific nuclear structural 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：减数分裂特异性核结构 1

种属: Homo sapiens

同用名: HTX9; SPATA40

基因 ID: 55329 | 基因类型: protein coding

关于 MNS1

Cytogenetic location: 15q21.3 Genomic coordinates (GRCh38): 15:56,428,724-56,465,137 (from NCBI)

This gene has 3 transcripts (splice variants), 207 orthologues and is associated with 1 phenotype. Biased expression in testis (RPKM 28.7), kidney (RPKM 5.6) and 13 other tissues.

功能概要

该基因编码的蛋白质与小鼠减数分裂特异性核结构蛋白 1 高度相似。小鼠蛋白显示在精子发生过程中的粗线期阶段表达，并且可能作为核骨架蛋白在减数分裂过程中调节核形态。[RefSeq 提供，2008 年 10 月]

This gene encodes a protein highly similar to the mouse meiosis-specific nuclear structural 1 protein. The mouse protein was shown to be expressed at the pachytene stage during spermatogenesis and may function as a nuclear skeletal protein to regulate nuclear morphology during meiosis. [provided by RefSeq, Oct 2008]

MNS1 基因产物(1)

mRNA Protein Name
NM_018365.4 NP_060835.1 meiosis-specific nuclear structural protein 1
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables identical protein binding IDA
IDA: 通过直接分析推断
22396656 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
30148830 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axonemal microtubule IDA
IDA: 通过直接分析推断
36191189 GOA
located in axoneme IDA
IDA: 通过直接分析推断
30148830 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MNS1 蛋白结构

TPH

TPH: Trichohyalin-plectin-homology domain (116 - 465)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 495 a.a.
蛋白主名 其他名称

meiosis-specific nuclear structural protein 1

spermatogenesis associated 40

MNS1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
MNS1 Q8NEH6 ZGPAT Homo sapiens Q8N5A5-2
Y2H Array
32296183
种属内
MNS1 Q8NEH6 ZGPAT Homo sapiens Q8N5A5-2
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 KRT34 Homo sapiens O76011
Y2H Array
32296183
种属内
MNS1 Q8NEH6 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 CEP63 Homo sapiens Q96MT8-3
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 CEP63 Homo sapiens Q96MT8-3
Validated Y2H
32296183
种属内
MNS1 Q8NEH6 CEP63 Homo sapiens Q96MT8-3
Y2H Array
32296183
种属内
MNS1 Q8NEH6 CDR2 Homo sapiens Q01850
Y2H Array
32296183
种属内
MNS1 Q8NEH6 CDR2 Homo sapiens Q01850
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 IQCB1 Homo sapiens Q15051-2
Y2H Array
32296183
种属内
MNS1 Q8NEH6 IQCB1 Homo sapiens Q15051-2
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 FCHSD2 Homo sapiens O94868-3
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 FCHSD2 Homo sapiens O94868-3
Y2H Array
32296183
种属内
MNS1 Q8NEH6 DISC1 Homo sapiens Q9NRI5-2
Y2H Array
32296183
种属内
MNS1 Q8NEH6 DISC1 Homo sapiens Q9NRI5-2
Validated Y2H
32296183
种属内
MNS1 Q8NEH6 DISC1 Homo sapiens Q9NRI5-2
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 ZMYND12 Homo sapiens Q9H0C1
Y2H Array
32296183
种属内
MNS1 Q8NEH6 ZMYND12 Homo sapiens Q9H0C1
Validated Y2H
32296183
种属内
MNS1 Q8NEH6 ZMYND12 Homo sapiens Q9H0C1
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 EP400 Homo sapiens A0A0A0MR80
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 EP400 Homo sapiens A0A0A0MR80
Y2H Array
32296183
种属内
MNS1 Q8NEH6 TRIM54 Homo sapiens Q9BYV2
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 TRIM54 Homo sapiens Q9BYV2
Validated Y2H
32296183
种属内
MNS1 Q8NEH6 TRIM54 Homo sapiens Q9BYV2
Y2H Array
32296183
种属内
MNS1 Q8NEH6 KANK2 Homo sapiens Q63ZY3
Y2H Array
32296183
种属内
MNS1 Q8NEH6 KANK2 Homo sapiens Q63ZY3
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 CHAT Homo sapiens P28329-3
Validated Y2H
32814053
种属内
MNS1 Q8NEH6 CHAT Homo sapiens P28329-3
Y2H Array
32814053
种属内
MNS1 Q8NEH6 CHAT Homo sapiens P28329-3
Y2H Pooling
32814053
种属内
MNS1 Q8NEH6 KIAA0753 Homo sapiens Q2KHM9
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 KIAA0753 Homo sapiens Q2KHM9
Y2H Array
32296183
种属内
MNS1 Q8NEH6 KRT75 Homo sapiens O95678
Validated Y2H
32296183
种属内
MNS1 Q8NEH6 KRT75 Homo sapiens O95678
Y2H Array
32296183
种属内
MNS1 Q8NEH6 KRT75 Homo sapiens O95678
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 HRAS Homo sapiens P01112
Validated Y2H
32814053
种属内
MNS1 Q8NEH6 HRAS Homo sapiens P01112
Y2H Array
32814053
种属内
MNS1 Q8NEH6 HRAS Homo sapiens P01112
Y2H Pooling
32814053
种属内
MNS1 Q8NEH6 AATF Homo sapiens Q9NY61
Y2H Array
32296183
种属内
MNS1 Q8NEH6 AATF Homo sapiens Q9NY61
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 AATF Homo sapiens Q9NY61
Validated Y2H
32296183
种属内
MNS1 Q8NEH6 CCND3 Homo sapiens P30281
Y2H Array
32296183
种属内
MNS1 Q8NEH6 CCND3 Homo sapiens P30281
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 THOC7 Homo sapiens Q6I9Y2
Y2H Array
32296183
种属内
MNS1 Q8NEH6 THOC7 Homo sapiens Q6I9Y2
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 STMN3 Homo sapiens Q9NZ72
Y2H Array
32296183
种属内
MNS1 Q8NEH6 STMN3 Homo sapiens Q9NZ72
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 STMN3 Homo sapiens Q9NZ72
Validated Y2H
32296183
种属内
MNS1 Q8NEH6 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
种属内
MNS1 Q8NEH6 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 TNNI1 Homo sapiens P19237
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 TNNI1 Homo sapiens P19237
Y2H Array
32296183
种属内
MNS1 Q8NEH6 RSPH14 Homo sapiens Q9UHP6
Validated Y2H
32296183
种属内
MNS1 Q8NEH6 TNNI2 Homo sapiens P48788
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 TNNI2 Homo sapiens P48788
Y2H Array
32296183
种属内
MNS1 Q8NEH6 PICK1 Homo sapiens Q9NRD5
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 PICK1 Homo sapiens Q9NRD5
Validated Y2H
32296183
种属内
MNS1 Q8NEH6 PICK1 Homo sapiens Q9NRD5
Y2H Array
32296183
种属内
MNS1 Q8NEH6 SNX32 Homo sapiens Q86XE0
Y2H Array
32296183
种属内
MNS1 Q8NEH6 SNX32 Homo sapiens Q86XE0
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 TTC23 Homo sapiens Q5W5X9-3
Y2H Array
32296183
种属内
MNS1 Q8NEH6 TTC23 Homo sapiens Q5W5X9-3
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 GIGYF1 Homo sapiens O75420
Y2H Prey Pooling
32296183
种属内
MNS1 Q8NEH6 GIGYF1 Homo sapiens O75420
Y2H Array
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Heterotaxy, Visceral, 9, Autosomal, With Male Infertility

HTX9
Situs Inversus

Situs Inversus Viscerum

Laterality Sequence

Complete Transposition

Siv
Dextrocardia With Situs Inversus

Situs Inversus Totalis

Complete Situs Inversus

Complete Situs Inversus Viscerum

Situs Inversus
Male Infertility

Infertility, Male

Infertility Male

Male Sterility

Absolute Infertility
Osteogenesis Imperfecta, Type Xiv

Osteogenesis Imperfecta Type 14

OI14

Osteogenesis Imperfecta Type Xiv

Oi, Type Xiv

Osteogenesis Imperfecta 14

Oi Type Xiv

Oi-Xiv
Visceral Heterotaxy

Situs Ambiguus

Heterotaxia

Heterotaxy Syndrome

Heterotaxy

Lateralization Defect

Situs Ambiguous

Left Isomerism

Htx

Ivemark Syndrome

Right Isomerism

Situs Ambiguus Viscerum

Incomplete Situs Inversus

Partial Situs Inversus

Heterotaxy, Visceral

Asplenia Syndrome

Bilateral Left-Sidedness

Polysplenia Syndrome

Moller Syndrome
Infertility
Borderline Glaucoma

Preglaucoma
Polycystic Kidney Disease 2 With Or Without Polycystic Liver Disease

Polycystic Kidney Disease 2

PKD2

Polycystic Kidney Disease, Adult, Type Ii

Apkd2

Polycystic Kidney Disease, Type 2

Adpkd2

Adult Polycystic Kidney Disease Type 2

Autosomal Dominant Polycystic Kidney Disease 2

Pkd-2

Polycystic Kidney Disease Adult Type Ii

Polycystic Kidney Type 2 Autosomal Dominant Disease

Kidney Disease, Polycystic, Type 2
Primary Ciliary Dyskinesia

Immotile Cilia Syndrome

Kartagener Syndrome

Dextrocardia Bronchiectasis And Sinusitis

Pcd

Ciliary Motility Disorders

Ciliary Motility Disorder

Immotile Ciliary Syndrome

Ciliary Dyskinesia Primary

Ics

Polynesian Bronchiectasis

Dextrocardia-Bronchiectasis-Sinusitis Syndrome

Immotile Cilia Syndrome, Kartagener Type

Primary Ciliary Dyskinesia And Situs Inversus

Primary Ciliary Dyskinesia, Kartagener Type

Siewert Syndrome

Dyskinesia, Ciliary, Primary
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08569 MNS1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus MNS1 RGD RGD:1549718
Macaca mulatta MNS1 VGNC VGNC:74861
Canis familiaris MNS1 VGNC VGNC:43297
Mus musculus MNS1 MGD MGI:107933
Bos taurus MNS1 VGNC VGNC:31539
Felis catus MNS1 VGNC VGNC:104496
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