2. Gene
  3. PPP3R1 - protein phosphatase 3 regulatory subunit B, alpha Gene

PPP3R1 - protein phosphatase 3 regulatory subunit B, alpha Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：蛋白磷酸酶 3 调节亚基 B，α

种属: Homo sapiens

同用名: CNB; CNB1; CALNB1

基因 ID: 5534 | 基因类型: protein coding

关于 PPP3R1

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:68,178,857-68,252,532 (from NCBI)

This gene has 3 transcripts (splice variants), 213 orthologues and 8 paralogues. Ubiquitous expression in brain (RPKM 81.4), fat (RPKM 34.1) and 24 other tissues.

功能概要

启用环孢菌素 A 结合活性；磷酸酶结合活性；和蛋白质结构域特异性结合活性。参与钙调神经磷酸酶-NFAT 信号级联和 RNA 聚合酶 II 对转录的正调控。神经钙蛋白复合物的一部分。与阿尔茨海默病和扩张型心肌病有关。 [由基因组资源联盟提供，2022 年 4 月]

Enables cyclosporin A binding activity; Phosphatase binding activity; and protein domain specific binding activity. Involved in calcineurin-NFAT signaling cascade and positive regulation of transcription by RNA polymerase II. Part of Calcineurin complex. Implicated in Alzheimer's disease and dilated cardiomyopathy. [provided by Alliance of Genome Resources, Apr 2022]

PPP3R1 基因产物(1)

mRNA Protein Name
NM_000945.4 NP_000936.1 calcineurin subunit B type 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphatase binding IPI
IPI: 通过物理相互作用推断
26794871 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
8524402 GOA
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
20639889 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcineurin-NFAT signaling cascade IDA
IDA: 通过直接分析推断
22688515 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
22688515 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of calcineurin complex IDA
IDA: 通过直接分析推断
12218175 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

calcineurin subunit B type 1

calcineurin B, type I (19kDa)

重组 PPP3R1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7705 Calcineurin B Protein, Human (His) P63098 (M1-V170) ≥95%

关联疾病

疾病名称 别名
Dilated Cardiomyopathy

Familial Dilated Cardiomyopathy

Primary Dilated Cardiomyopathy

Idiopathic Dilated Cardiomyopathy

Congestive Cardiomyopathy

Idiopathic Dilation Cardiomyopathy

Primary Familial Dilated Cardiomyopathy

Cardiomyopathy, Dilated

DCM

Cardiomyopathy, Familial Dilated

Dilated Cardiomyopathy, Familial

Hypokinetic Dilated Cardiomyopathy, Familial

Familial Idiopathic Cardiomyopathy

Fdc

Cardiomyopathy, Familial Idiopathic

Idiopathic Cardiomegaly

Dilated Congestive Cardiomyopathy

Chronic Dilated Cardiomyopathy

Ccm - [Congestive Cardiomyopathy]

Cocm - [Congestive Cardiomyopathy]

Dcm - [Dilated Cardiomyopathy]

Dilated-Hypokinetic Cardiomyopathy

Congestive Idiopathic Cardiomyopathy

Primary Idiopathic Dilated Cardiomyopathy
Spinocerebellar Ataxia, X-Linked 3

Scax3

X-Linked Spinocerebellar Ataxia 3

X-Linked Ataxia-Deafness Syndrome

X-Linked Spinocerebellar Ataxia Type 3

Ataxia-Deafness Syndrome, X-Linked

Spinocerebellar Ataxia X-Linked Type 3

Ataxia-Deafness Syndrome X-Linked

X-Linked Ataxia-Hearing Loss Syndrome

Spinocerebellar Ataxia, X-Linked, 3
Spinocerebellar Ataxia, X-Linked 4

Scax4

X-Linked Spinocerebellar Ataxia 4

X-Linked Ataxia-Dementia Syndrome

X-Linked Spinocerebellar Ataxia Type 4

Ataxia-Dementia Syndrome, X-Linked

Spinocerebellar Ataxia X-Linked Type 4

Ataxia-Dementia Syndrome X-Linked

Spinocerebellar Ataxia, X-Linked, 4
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS11026 PPP3R1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris PPP3R1 VGNC VGNC:108213
Mus musculus PPP3R1 MGD MGI:107172
Rattus norvegicus PPP3R1 RGD RGD:69230
Bos taurus PPP3R1 VGNC VGNC:50247
Others PPP3R1 NCBI
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