PIDD1 - p53-induced death domain protein 1 Gene

中文名称：p53 诱导的死亡域蛋白 1

种属: Homo sapiens

同用名: LRDD; PIDD; MRT75

关于 PIDD1

功能概要

该基因编码的蛋白质包含一个富含亮氨酸的重复序列和一个死亡域。该蛋白已被证明与其他死亡结构域蛋白相互作用，例如通过死亡结构域相关的 Fas (TNFRSF6) (FADD) 和 MAP 激酶激活死亡结构域蛋白 (MADD) ，因此可能作为衔接蛋白在细胞死亡相关的信号过程。已经发现该基因的小鼠对应物的表达受肿瘤抑制因子 p53 的正向调节，并诱导细胞凋亡以响应 DNA 损伤，这表明该基因作为 p53 依赖性细胞凋亡的效应子的作用。可变剪接导致多个转录本变体。[RefSeq 提供，2010 年 8 月]

The protein encoded by this gene contains a leucine-rich repeat and a death domain. This protein has been shown to interact with Other death domain proteins, such as Fas (TNFRSF6)-associated via death domain (FADD) and MAP-kinase activating death domain-containing protein (MADD), and thus may function as an adaptor protein in cell death-related signaling processes. The expression of the mouse counterpart of this gene has been found to be positively regulated by the tumor suppressor p53 and to induce cell Apoptosis in response to DNA damage, which suggests a role for this gene as an effector of p53-dependent Apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2010]