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  2. FOXJ2 - forkhead box J2 Gene

FOXJ2 - forkhead box J2 Gene

中文名称:叉头盒 J2

种属: Homo sapiens

同用名: FHX

基因 ID: 55810 | 基因类型: protein coding

关于 FOXJ2

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:8,032,716-8,055,517 (from NCBI)

This gene has 3 transcripts (splice variants), 124 orthologues and 42 paralogues. Ubiquitous expression in endometrium (RPKM 8.4), ovary (RPKM 8.2) and 25 other tissues.

功能概要

启用 DNA 结合转录激活剂活性,RNA 聚合酶 II 特异性; RNA 聚合酶 II 顺式调节区序列特异性 DNA 结合活性;和相同的蛋白质结合活性。参与多个过程,包括血管生成的负调节;血管内皮细胞分化的负调控;血管相关平滑肌细胞增殖的正向调节。位于纤维中心和核质中。 [由基因组资源联盟提供,2022 年 4 月]

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and identical protein binding activity. Involved in several processes, including negative regulation of angiogenesis; negative regulation of blood vessel endothelial cell differentiation; and positive regulation of vascular associated smooth muscle cell proliferation. Located in fibrillar center and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

FOXJ2 基因产物(1)

mRNA Protein Name
NM_018416.3 NP_060886.1 forkhead box protein J2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
10777590 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10777590 GOA
enables identical protein binding IPI
IPI: 通过物理相互作用推断
25609649 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
enables sequence-specific DNA binding IDA
IDA: 通过直接分析推断
10777590 GOA
enables sequence-specific double-stranded DNA binding IDA
IDA: 通过直接分析推断
28473536 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
24792364 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

FOXJ2 蛋白结构

Forkhead

Forkhead: Forkhead domain (66 - 144)

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  • 574 a.a.
蛋白主名 其他名称

forkhead box protein J2

FOXJ2 forkhead factor

FOXJ2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
FOXJ2 Q9P0K8 EGLN3 Homo sapiens Q9H6Z9
Y2H Prey Pooling
25416956
种属内
FOXJ2 Q9P0K8 EGLN3 Homo sapiens Q9H6Z9
Validated Y2H
25416956
种属内
FOXJ2 Q9P0K8 EYA4 Homo sapiens O95677
TAP
25609649
种属内
FOXJ2 Q9P0K8 DLX5 Homo sapiens P56178
TAP
25609649
种属内
FOXJ2 Q9P0K8 FOXF2 Homo sapiens Q12947
TAP
25609649
种属内
FOXJ2 Q9P0K8 BBX Homo sapiens Q8WY36
TAP
25609649
种属内
FOXJ2 Q9P0K8 FOXC1 Homo sapiens Q12948
TAP
25609649
种属内
FOXJ2 Q9P0K8 ADNP Homo sapiens Q9H2P0
TAP
25609649
种属内
FOXJ2 Q9P0K8 ESS2 Homo sapiens Q96DF8
TAP
25609649
种属内
FOXJ2 Q9P0K8 EMSY Homo sapiens Q7Z589
TAP
25609649
种属内
FOXJ2 Q9P0K8 CUX1 Homo sapiens P39880
TAP
25609649
种属内
FOXJ2 Q9P0K8 AKAP8 Homo sapiens O43823
TAP
25609649
种属内
FOXJ2 Q9P0K8 CSTF2T Homo sapiens Q9H0L4
Validated Y2H
32296183
种属内
FOXJ2 Q9P0K8 FOXJ2 Homo sapiens Q9P0K8
TAP
25609649
种属内
FOXJ2 Q9P0K8 DNTTIP1 Homo sapiens Q9H147
TAP
25609649
种属内
FOXJ2 Q9P0K8 CHD4 Homo sapiens Q14839
TAP
25609649
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Felis catus FOXJ2 VGNC VGNC:62337
Macaca mulatta FOXJ2 VGNC VGNC:72568
Bos taurus FOXJ2 VGNC VGNC:29090
Rattus norvegicus FOXJ2 RGD RGD:1565101
Canis familiaris FOXJ2 VGNC VGNC:40955
Mus musculus FOXJ2 MGD MGI:1926805