SPHK2 - sphingosine kinase 2 Gene

中文名称：鞘氨醇激酶 2

种属: Homo sapiens

同用名: SK 2; SK-2; SPK 2; SPK-2

基因 ID: 56848 | 基因类型: protein coding

关于 SPHK2

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,619,506-48,630,405 (from NCBI)

This gene has 13 transcripts (splice variants), 209 orthologues and 4 paralogues. Ubiquitous expression in kidney (RPKM 6.4), duodenum (RPKM 5.5) and 25 other tissues.

功能概要

该基因编码两种鞘氨醇激酶同工酶中的一种，可催化鞘氨醇磷酸化为鞘氨醇 1-磷酸。鞘氨醇 1-磷酸介导许多细胞过程，包括迁移、增殖和细胞凋亡，并且还通过促进血管生成和肿瘤发生在多种类型的癌症中发挥作用。编码的蛋白质可能在乳腺癌增殖和化学抗性中发挥作用。已经观察到该基因编码多种亚型的可变剪接转录物变体。[RefSeq 提供，2011 年 8 月]

This gene encodes one of two sphingosine kinase isozymes that catalyze the phosphorylation of sphingosine into sphingosine 1-phosphate. Sphingosine 1-phosphate mediates many cellular processes including migration, proliferation and Apoptosis, and also plays a role in several types of Cancer by promoting angiogenesis and tumorigenesis. The encoded protein may play a role in breast Cancer proliferation and chemoresistance. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]

SPHK2 基因产物(13)

mRNA	Protein	Name
XM_017027008.2	XP_016882497.1	sphingosine kinase 2 isoform X1
XM_011527134.2	XP_011525436.1	sphingosine kinase 2 isoform X3
XM_047439106.1	XP_047295062.1	sphingosine kinase 2 isoform X3
XM_011527133.2	XP_011525435.1	sphingosine kinase 2 isoform X2
NM_020126.5	NP_064511.2	sphingosine kinase 2 isoform a
NM_001204159.3	NP_001191088.1	sphingosine kinase 2 isoform a
NM_001204160.3	NP_001191089.1	sphingosine kinase 2 isoform c
NM_001204158.3	NP_001191087.1	sphingosine kinase 2 isoform b
XM_006723292.2	XP_006723355.1	sphingosine kinase 2 isoform X3
XM_047439107.1	XP_047295063.1	sphingosine kinase 2 isoform X4
NM_001243876.2	NP_001230805.1	sphingosine kinase 2 isoform d
XM_047439108.1	XP_047295064.1	sphingosine kinase 2 isoform X4
XM_017027010.3	XP_016882499.1	sphingosine kinase 2 isoform X4

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables D-erythro-sphingosine kinase activity	IDA IDA: 通过直接分析推断	10751414	GOA
enables histone binding	IDA IDA: 通过直接分析推断	19729656	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	11777919	GOA
enables sphingosine kinase activity	IDA IDA: 通过直接分析推断	19729656	GOA
enables sphingosine-1-phosphate receptor activity	IMP IMP: 通过突变表型推断	23106337	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in cellular response to phorbol 13-acetate 12-myristate	IDA IDA: 通过直接分析推断	17635916	GOA
involved in positive regulation of apoptotic process	IDA IDA: 通过直接分析推断	16118219	GOA
involved in positive regulation of ceramide biosynthetic process	IDA IDA: 通过直接分析推断	16118219	GOA
involved in regulation of cytochrome-c oxidase activity	IMP IMP: 通过突变表型推断	20959514	GOA
involved in sphinganine-1-phosphate biosynthetic process	IDA IDA: 通过直接分析推断	10751414	GOA
involved in sphingosine biosynthetic process	IGI IGI: 通过遗传相互作用推断	23106337	GOA
involved in sphingosine biosynthetic process	IMP IMP: 通过突变表型推断	23106337	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: 通过直接分析推断	19729656	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	16103110	GOA
located in cytosol	IDA IDA: 通过直接分析推断	10751414	GOA
located in membrane	IDA IDA: 通过直接分析推断	10751414	GOA
part of nucleosome	IDA IDA: 通过直接分析推断	19729656	GOA
located in nucleus	IDA IDA: 通过直接分析推断	16103110	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SPHK2 蛋白结构

DAGK_cat

0
200
400
600
654 a.a.

蛋白主名

其他名称

sphingosine kinase 2

SPHK2 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	SPHK2	Q9NRA0	OPTN	Homo sapiens	Q96CV9	Validated Y2H	32814053
种属内	SPHK2	Q9NRA0	OPTN	Homo sapiens	Q96CV9	Y2H Pooling	32814053
种属内	SPHK2	Q9NRA0	OPTN	Homo sapiens	Q96CV9	Y2H Array	32814053

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Dermatitis, Atopic, 7

ATOD7	Dermatitis, Atopic, Susceptibility To, 7
Atopic Dermatitis 7	Dermatitis, Atopic 7

Breast Cancer

Breast Carcinoma	Breast Cancer, Familial
Malignant Neoplasm Of Breast	Male Breast Cancer
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Ureteral Obstruction

Brachydactyly, Type E1

Brachydactyly Type E1	Brachydactyly Type E
BDE1	Brachydactyly, Type E
Bde	Type E Brachydactyly
Brachydactyly E1	Brachydactyly Syndrome Type E

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-15779A	K145 hydrochloride	Inhibitor	99.88%	否
HY-12892	SKI-178	Inhibitor	98.91%	否
HY-147282	Amgen-23	Inhibitor	99.00%	否
HY-148707	SphK1&2-IN-1	Inhibitor	99.33%	否
HY-151350	SphK2-IN-1	Inhibitor	/	否
HY-150615	SphK1-IN-2	Inhibitor	/	否

直系同源

种属	基因名	来源	基因 ID
Bos taurus	SPHK2	VGNC	VGNC:35211
Rattus norvegicus	SPHK2	RGD	RGD:1307757
Macaca mulatta	SPHK2	VGNC	VGNC:77960
Mus musculus	SPHK2	MGD	MGI:1861380
Canis familiaris	SPHK2	VGNC	VGNC:46737
Others	SPHK2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SPHK2 - sphingosine kinase 2 Gene

关于 SPHK2

功能概要

SPHK2 基因产物(13)

SPHK2 蛋白结构

SPHK2 蛋白互作信息

关联疾病

直系同源

热门区域

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SPHK2 - sphingosine kinase 2 Gene

关于 SPHK2

功能概要

SPHK2 基因产物(13)

SPHK2 蛋白结构

SPHK2 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z