2. Gene
  3. AKR1B10 - aldo-keto reductase family 1 member B10 Gene

AKR1B10 - aldo-keto reductase family 1 member B10 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：醛酮还原酶家族 1 成员 B10

种属: Homo sapiens

同用名: HIS; HSI; ARL1; ARL-1; ALDRLn; AKR1B11; AKR1B12

基因 ID: 57016 | 基因类型: protein coding

关于 AKR1B10

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:134,527,567-134,541,412 (from NCBI)

This gene has 4 transcripts (splice variants), 563 orthologues and 16 paralogues. Biased expression in duodenum (RPKM 190.1), stomach (RPKM 138.2) and 4 other tissues.

功能概要

该基因编码醛/酮还原酶超家族的一个成员，该家族由 40 多种已知的酶和蛋白质组成。该成员能有效还原脂肪族和芳香族醛，对己糖活性较低。它在肾上腺、小肠和结肠中高表达，可能在肝癌发生中起重要作用。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known Enzymes and proteins. This member can efficiently reduce aliphatic and aromatic aldehydes, and it is less active on hexoses. It is highly expressed in adrenal gland, small intestine, and colon, and may play an important role in liver carcinogenesis. [provided by RefSeq, Jul 2008]

AKR1B10 基因产物(1)

mRNA Protein Name
NM_020299.5 NP_064695.3 aldo-keto reductase family 1 member B10
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables alcohol dehydrogenase (NADP+) activity IDA
IDA: 通过直接分析推断
19013440 GOA
enables all-trans-retinol dehydrogenase (NADP+) activity IDA
IDA: 通过直接分析推断
12732097 GOA
enables geranylgeranyl reductase activity IDA
IDA: 通过直接分析推断
21187079 GOA
enables indanol dehydrogenase activity IDA
IDA: 通过直接分析推断
20837989 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
18056116 GOA
enables retinal dehydrogenase activity IDA
IDA: 通过直接分析推断
21851338 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular detoxification of aldehyde IDA
IDA: 通过直接分析推断
19013440 GOA
involved in daunorubicin metabolic process IMP
IMP: 通过突变表型推断
20837989 GOA
involved in doxorubicin metabolic process IMP
IMP: 通过突变表型推断
20837989 GOA
involved in farnesol catabolic process IDA
IDA: 通过直接分析推断
21187079 GOA
involved in retinoid metabolic process IDA
IDA: 通过直接分析推断
12732097 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular region IDA
IDA: 通过直接分析推断
21585341 GOA
located in lysosome IDA
IDA: 通过直接分析推断
21585341 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

AKR1B10 蛋白结构

Aldo_ket_red

Aldo_ket_red: Aldo/keto reductase family (16 - 291)

  • 0
  • 100
  • 200
  • 316 a.a.
蛋白主名 其他名称

aldo-keto reductase family 1 member B10

ARP

关联疾病

疾病名称 别名
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma
Diabetic Cataract

Cataract - Diabetic
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-105185 Fidarestat Inhibitor 99.63% 否
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139696 AKR1B10-IN-1 Inhibitor ≥95.0% 否
HY-W040265 Fenamic acid Inhibitor 98.19% 否
HY-RS00533 AKR1B10 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-168526 Keap1-Nrf2-IN-24 Inhibitor / 否
HY-122177 MK181 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus AKR1B10 RGD RGD:1308277
Others AKR1B10 NCBI
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